ES2104821T3 - Cetoacidos que contienen quinoleina como antagonistas de leucotrienos. - Google Patents

Cetoacidos que contienen quinoleina como antagonistas de leucotrienos.

Info

Publication number
ES2104821T3
ES2104821T3 ES92301393T ES92301393T ES2104821T3 ES 2104821 T3 ES2104821 T3 ES 2104821T3 ES 92301393 T ES92301393 T ES 92301393T ES 92301393 T ES92301393 T ES 92301393T ES 2104821 T3 ES2104821 T3 ES 2104821T3
Authority
ES
Spain
Prior art keywords
cetoacides
quinolein
antagonists
leucotrene
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92301393T
Other languages
English (en)
Inventor
Michel L Belley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Application granted granted Critical
Publication of ES2104821T3 publication Critical patent/ES2104821T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPUESTOS PROVISTOS DE LA FORMULA I: SON ANTAGONISTAS DE LAS ACCIONES DE LOS LEUKOTRIENES. ESTOS COMPUESTOS SE UTILIZAN COMO AGENTES ANTIASMATICOS, ANTIALERGICOS, ANTIINFLAMATORIOS Y CITOPROTECTORES, SE UTILIZAN TAMBIEN EN EL TRATAMIENTO DE LA ANGINA, DEL ESPASMO CEREBRAL, DE LA NEFRITIS GLOMERULAR, DE LA HEPATITIS, DE LA UVEITIS Y DEL RECHAZO ALOGRAFICO.
ES92301393T 1991-02-21 1992-02-20 Cetoacidos que contienen quinoleina como antagonistas de leucotrienos. Expired - Lifetime ES2104821T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65893191A 1991-02-21 1991-02-21

Publications (1)

Publication Number Publication Date
ES2104821T3 true ES2104821T3 (es) 1997-10-16

Family

ID=24643302

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92301393T Expired - Lifetime ES2104821T3 (es) 1991-02-21 1992-02-20 Cetoacidos que contienen quinoleina como antagonistas de leucotrienos.

Country Status (17)

Country Link
EP (1) EP0500360B1 (es)
JP (1) JPH0788361B2 (es)
KR (1) KR920016423A (es)
CN (1) CN1065062A (es)
AT (1) ATE154801T1 (es)
AU (1) AU648385B2 (es)
CA (1) CA2061675C (es)
CS (1) CS47192A3 (es)
DE (1) DE69220517T2 (es)
ES (1) ES2104821T3 (es)
FI (1) FI920734A (es)
HU (1) HU9200552D0 (es)
IE (1) IE920499A1 (es)
IL (1) IL100985A0 (es)
MX (1) MX9200714A (es)
NO (1) NO920681L (es)
ZA (1) ZA921232B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
GB9216768D0 (en) * 1992-08-07 1992-09-23 Leo Pharm Prod Ltd Chemical compounds
EP0830133A1 (en) * 1995-04-28 1998-03-25 Takeda Chemical Industries, Ltd. Therapeutic composition for arthritis
WO1998008820A1 (fr) * 1996-08-26 1998-03-05 Yamanouchi Pharmaceutical Co., Ltd. Composes de benzenesulfone et sels de ces derniers
AU742237B2 (en) * 1998-07-14 2001-12-20 Alcon Manufacturing Limited Use of 11-(3-dimenthylaminopropylidene)-6,11-dihydrodibenz (B,E)oxepin-2-acetic acid for the manufacture of medicament for treating non-allergic opthalmic inflammatory disorders and for the prevention of ocular neovascularization
DE602005015174D1 (de) 2004-04-21 2009-08-13 Teva Pharma Verfahren zur herstellung von montelukast-natrium
ITMI20050247A1 (it) 2005-02-18 2006-08-19 Chemi Spa Processo per la preparazione di montelukast
WO2006131782A1 (en) * 2005-06-07 2006-12-14 Glade Organics Private Limited Process for the manufacture of methyl-2-(3-(2-(7-chloro-2-quinolinyl-ethenyl)-phenyl)-3-oxopropyl) benzoate
CA2608369A1 (en) 2005-07-05 2007-01-11 Teva Pharmaceutical Industries Ltd. Purification of montelukast
CN101356158B (zh) * 2005-11-18 2011-12-14 斯索恩有限公司 用于制备孟鲁司特的中间体及相关的化合物
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
WO2008032099A2 (en) * 2006-09-15 2008-03-20 Cipla Limited Process for the preparation of montelukast, and intermediates therefor
ES2320077B1 (es) * 2007-07-31 2010-02-26 Moehs Iberica, S.L. Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo.
CN101851196B (zh) * 2010-05-28 2011-07-27 中国科学院昆明植物研究所 2-(1h)喹啉酮衍生物,其药物组合物及其制备方法和用途
JP6038914B2 (ja) * 2011-07-26 2016-12-07 スン プハルマ アドバンセド リサーチ カンパニー リミテド キノリン−、キノキサリン、又はベンゾチアゾールベースのシステイニルロイコトリエンアンタゴニスト（ｌｔｃ４）

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
IL88433A0 (en) * 1987-11-25 1989-06-30 Merck Frosst Canada Inc Diarylstyrylquinoline diacids and pharmaceutical compositions containing them
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
NO920681L (no) 1992-08-24
DE69220517D1 (de) 1997-07-31
IL100985A0 (en) 1992-11-15
ZA921232B (en) 1992-10-28
CS47192A3 (en) 1992-10-14
HU9200552D0 (en) 1992-05-28
CA2061675A1 (en) 1992-08-22
AU648385B2 (en) 1994-04-21
EP0500360B1 (en) 1997-06-25
DE69220517T2 (de) 1997-12-18
FI920734A0 (fi) 1992-02-20
NO920681D0 (no) 1992-02-20
CA2061675C (en) 2002-12-17
FI920734A (fi) 1992-08-22
AU1111992A (en) 1992-08-27
JPH0525135A (ja) 1993-02-02
CN1065062A (zh) 1992-10-07
ATE154801T1 (de) 1997-07-15
KR920016423A (ko) 1992-09-24
EP0500360A1 (en) 1992-08-26
JPH0788361B2 (ja) 1995-09-27
MX9200714A (es) 1992-10-01
IE920499A1 (en) 1992-08-26

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