ES2104637T3 - Peptidos con una actividad antagonista para la bombesina/grp. - Google Patents

Peptidos con una actividad antagonista para la bombesina/grp.

Info

Publication number
ES2104637T3
ES2104637T3 ES91112504T ES91112504T ES2104637T3 ES 2104637 T3 ES2104637 T3 ES 2104637T3 ES 91112504 T ES91112504 T ES 91112504T ES 91112504 T ES91112504 T ES 91112504T ES 2104637 T3 ES2104637 T3 ES 2104637T3
Authority
ES
Spain
Prior art keywords
grp
bombesin
derivatives
peptidos
pump
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91112504T
Other languages
English (en)
Inventor
John L Krstenansky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2104637T3 publication Critical patent/ES2104637T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN METODO PARA CONTROLAR EL CRECIMIENTO DE TEJIDOS DE TUMORES, ESPECIALMENTE CELULAS PEQUEÑAS DEL PULMON Y CARCINOMAS PROSTATICOS, Y SECRECION ACIDA GASTRICA, CAUSADA Y SINTOMATICA DE, ULCERAS (ESOFAGIALES, GASTRICAS, Y DUODENALES) PEPTICAS. EL TRATAMIENTO COMPRENDE EL ADMINISTRAR A UN PACIENTE EN SU NECESIDAD, UNA CANTIDAD EFICAZ DE UN INHIBIDOR TIPO BOMBESINA/GRP. SE DESCRIBEN ANTAGONISTAS DE BOMBESINA/GRP QUE SON DERIVADOS DE BOMBESINAS/GRP DE OCURRENCIA NATURAL POSEYENDO UNA UNION TIOMETILENA O DE SULFOXIDO DE METILENO CONECTANDO LOS DOS AMINO ACIDOS EN EL EXTREMO TERMINAL CARBOXIDO QUE ES MODIFICADO. SE DESCRIBEN TAMBIEN EL ANTAGONISMO QUE SE CONFIRMA UTILIZANDO UNA UNION COMPETITIVA CONVENCIONAL Y ENSAYOS BIOQUIMICOS ASI COMO EXAMENES FISIOLOGICOS CONVENCIONALES Y EL USO DE ESTOS DERIVADOS EN UNA VARIEDAD DE CONDICIONES EN LAS QUE LA BOMBESINA/GRP ESTA IMPLICADA.
ES91112504T 1990-07-26 1991-07-25 Peptidos con una actividad antagonista para la bombesina/grp. Expired - Lifetime ES2104637T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55803190A 1990-07-26 1990-07-26

Publications (1)

Publication Number Publication Date
ES2104637T3 true ES2104637T3 (es) 1997-10-16

Family

ID=24227892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91112504T Expired - Lifetime ES2104637T3 (es) 1990-07-26 1991-07-25 Peptidos con una actividad antagonista para la bombesina/grp.

Country Status (9)

Country Link
EP (1) EP0468497B1 (es)
JP (1) JP3304993B2 (es)
KR (1) KR100230876B1 (es)
AT (1) ATE153671T1 (es)
AU (1) AU641789B2 (es)
DE (1) DE69126254T2 (es)
ES (1) ES2104637T3 (es)
IE (1) IE912629A1 (es)
ZA (1) ZA915740B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
US5834433A (en) * 1990-07-26 1998-11-10 Merrell Pharmaceuticals Inc. Compounds and pharmaceutical uses of peptides of bombesin and GRP
CA2129032A1 (en) * 1992-02-07 1993-08-19 Judson V. Edwards Phenylalanine analogs of bombesin
US5436137A (en) * 1992-07-27 1995-07-25 Oregon Regional Primate Research Center DNA sequence which encodes a peptide capable of promoting acrosome reaction
US6989371B1 (en) 1996-08-16 2006-01-24 Dabur Research Foundation Bombesin analogs for treatment of cancer
US6492330B1 (en) 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs
WO2001062777A1 (en) * 2000-02-24 2001-08-30 Dabur Research Foundation Bombesin analogs for treatment of cancer
AU2004232314B2 (en) 2003-04-22 2007-11-22 Ipsen Pharma S.A.S. Peptide vectors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331661A (en) * 1980-10-03 1982-05-25 The Salk Institute For Biological Studies Bombesin analogs
WO1989002897A1 (en) * 1987-09-24 1989-04-06 The Administrators Of The Tulane Educational Fund Therapeutic peptides
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
US5019647A (en) * 1988-05-24 1991-05-28 Merck & Co., Inc. Gastrin releasing peptide antagonist
JP2919889B2 (ja) * 1988-10-14 1999-07-19 アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド 治療用ペプチド
US5028692A (en) * 1989-04-25 1991-07-02 Merck & Co., Inc. Gastrin releasing peptide antagonist

Also Published As

Publication number Publication date
DE69126254T2 (de) 1997-12-04
EP0468497B1 (en) 1997-05-28
IE912629A1 (en) 1992-01-29
KR100230876B1 (ko) 1999-11-15
EP0468497A3 (en) 1992-05-06
JPH04253997A (ja) 1992-09-09
AU641789B2 (en) 1993-09-30
ATE153671T1 (de) 1997-06-15
DE69126254D1 (de) 1997-07-03
KR920002628A (ko) 1992-02-28
JP3304993B2 (ja) 2002-07-22
AU8123691A (en) 1992-01-30
EP0468497A2 (en) 1992-01-29
ZA915740B (en) 1992-05-27

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