ES2103181A1 - Amidas naftalenicas con accion antagonista de los leucotrienos. - Google Patents
Amidas naftalenicas con accion antagonista de los leucotrienos.Info
- Publication number
- ES2103181A1 ES2103181A1 ES09401696A ES9401696A ES2103181A1 ES 2103181 A1 ES2103181 A1 ES 2103181A1 ES 09401696 A ES09401696 A ES 09401696A ES 9401696 A ES9401696 A ES 9401696A ES 2103181 A1 ES2103181 A1 ES 2103181A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- bound
- naphthalene
- leukotriene
- antagonistic action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
AMIDAS NAFTALENICAS CON ACCION ANTAGONISTA DE LOS LEUCOTRIENOS. LA PRESENTE INVENCION SE REFIERE A NUEVAS AMIDAS NAFTALENICAS DE FORMULA I, FORMULA DONDE EL SUSTITUYENTE QUE CONTIENE A A ESTA UNIDO A LA POSICION 6 O 7 DEL SISTEMA 2-NAFTOLICO; R1 ES HIDROGENO O METILO; R2 ES HIDROGENO, FLUOR, CLORO O -OCH3; R3 ES HIDROGENO, FLUOR, CLORO O BROMO; -A- ES -CO-NR4- O -NR4-CO-; R4 ES HIDROGENO O METILO; B ES 5-TETRAZOLILO O -COOR5, R5 ES HIDROGENO, (C1-C4)-ALQUILO O FENILALQUILO; M ES 0 O 1; N Y P SON ENTEROS COMPRENDIDOS ENTRE 0 Y 6, CON LA CONDICION DE QUE N+P SEA MENOR O IGUAL A 6. DICHOS COMPUESTOS PRESENTAN UNA ACCION ANTAGONISTA DE LOS LEUCOTRIENOS, PUDIENDO SER UTILIZADOS COMO ANTIINFLAMATORIOS, ANTIALERGICOS O EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA CARDIOVASCULAR.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09401696A ES2103181B1 (es) | 1994-08-01 | 1994-08-01 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
AT95929014T ATE201678T1 (de) | 1994-08-01 | 1995-07-27 | Naphthalenamide als leukotrien antagonisten |
DE69521132T DE69521132T2 (de) | 1994-08-01 | 1995-07-27 | Naphthalenamide als leukotrien antagonisten |
PT95929014T PT775133E (pt) | 1994-08-01 | 1995-07-27 | Amidas de naftaleno com accao antagonista do leucotrieno |
ES95929014T ES2156944T3 (es) | 1994-08-01 | 1995-07-27 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
PCT/EP1995/002970 WO1996004267A1 (en) | 1994-08-01 | 1995-07-27 | Naphthalene amides having leukotriene-antagonistic action |
EP95929014A EP0775133B1 (en) | 1994-08-01 | 1995-07-27 | Naphthalene amides having leukotriene-antagonistic action |
AU32539/95A AU3253995A (en) | 1994-08-01 | 1995-07-27 | Naphthalene amides having leukotriene-antagonistic action |
DK95929014T DK0775133T3 (da) | 1994-01-31 | 1995-07-27 | Naphthlenamider med leukotrien-antagonistisk virkning |
GR20010401313T GR3036462T3 (en) | 1994-08-01 | 2001-08-29 | Naphthalene amides having leukotriene-antagonistic action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09401696A ES2103181B1 (es) | 1994-08-01 | 1994-08-01 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2103181A1 true ES2103181A1 (es) | 1997-08-16 |
ES2103181B1 ES2103181B1 (es) | 1998-04-01 |
Family
ID=8287122
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09401696A Expired - Lifetime ES2103181B1 (es) | 1994-01-31 | 1994-08-01 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
ES95929014T Expired - Lifetime ES2156944T3 (es) | 1994-08-01 | 1995-07-27 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95929014T Expired - Lifetime ES2156944T3 (es) | 1994-08-01 | 1995-07-27 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0775133B1 (es) |
AT (1) | ATE201678T1 (es) |
AU (1) | AU3253995A (es) |
DE (1) | DE69521132T2 (es) |
ES (2) | ES2103181B1 (es) |
GR (1) | GR3036462T3 (es) |
PT (1) | PT775133E (es) |
WO (1) | WO1996004267A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2150848A1 (es) * | 1998-04-15 | 2000-12-01 | Menarini Lab | Heterociclos metiloxinaftil sustituidos con accion antagonista de los leucotrienos. |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2117551B1 (es) * | 1995-12-29 | 1999-04-01 | Menarini Lab | Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas. |
TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
DE60126143T2 (de) * | 2000-12-06 | 2007-11-15 | Sanofi-Aventis Deutschland Gmbh | Guanidin- und amidin-verbindungen, und ihre verwendung als faktor xa-inhibitoren |
TWI312779B (es) | 2000-12-28 | 2009-08-01 | Daiichi Seiyaku Co | |
TW591020B (en) * | 2001-06-20 | 2004-06-11 | Wyeth Corp | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
GB2405146A (en) * | 2002-06-07 | 2005-02-23 | Cortical Pty Ltd | Napthalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF) |
MXPA06000850A (es) | 2003-07-24 | 2006-03-30 | Daiichi Seiyaku Co | Compuesto de acido ciclohexancarboxilico. |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
EP0315399A2 (en) * | 1987-11-03 | 1989-05-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same |
EP0348155A1 (en) * | 1988-06-21 | 1989-12-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084575A (en) * | 1987-07-31 | 1992-01-28 | American Home Products Corporation | Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
-
1994
- 1994-08-01 ES ES09401696A patent/ES2103181B1/es not_active Expired - Lifetime
-
1995
- 1995-07-27 ES ES95929014T patent/ES2156944T3/es not_active Expired - Lifetime
- 1995-07-27 WO PCT/EP1995/002970 patent/WO1996004267A1/en active IP Right Grant
- 1995-07-27 DE DE69521132T patent/DE69521132T2/de not_active Expired - Fee Related
- 1995-07-27 EP EP95929014A patent/EP0775133B1/en not_active Expired - Lifetime
- 1995-07-27 AU AU32539/95A patent/AU3253995A/en not_active Abandoned
- 1995-07-27 PT PT95929014T patent/PT775133E/pt unknown
- 1995-07-27 AT AT95929014T patent/ATE201678T1/de not_active IP Right Cessation
-
2001
- 2001-08-29 GR GR20010401313T patent/GR3036462T3/el not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
EP0315399A2 (en) * | 1987-11-03 | 1989-05-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same |
EP0348155A1 (en) * | 1988-06-21 | 1989-12-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2150848A1 (es) * | 1998-04-15 | 2000-12-01 | Menarini Lab | Heterociclos metiloxinaftil sustituidos con accion antagonista de los leucotrienos. |
Also Published As
Publication number | Publication date |
---|---|
DE69521132D1 (de) | 2001-07-05 |
ATE201678T1 (de) | 2001-06-15 |
EP0775133B1 (en) | 2001-05-30 |
ES2156944T3 (es) | 2001-08-01 |
WO1996004267A1 (en) | 1996-02-15 |
GR3036462T3 (en) | 2001-11-30 |
AU3253995A (en) | 1996-03-04 |
DE69521132T2 (de) | 2001-09-27 |
PT775133E (pt) | 2001-10-30 |
ES2103181B1 (es) | 1998-04-01 |
EP0775133A1 (en) | 1997-05-28 |
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Legal Events
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EC2A | Search report published |
Date of ref document: 19970816 Kind code of ref document: A1 Effective date: 19970816 |