ES2102360T3 - Proteina de la superficie celular asociada a linfocitos. - Google Patents

Proteina de la superficie celular asociada a linfocitos.

Info

Publication number
ES2102360T3
ES2102360T3 ES90301884T ES90301884T ES2102360T3 ES 2102360 T3 ES2102360 T3 ES 2102360T3 ES 90301884 T ES90301884 T ES 90301884T ES 90301884 T ES90301884 T ES 90301884T ES 2102360 T3 ES2102360 T3 ES 2102360T3
Authority
ES
Spain
Prior art keywords
lam
cell surface
protein
cdna sequence
lymphocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90301884T
Other languages
English (en)
Inventor
Thomas F Tedder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Application granted granted Critical
Publication of ES2102360T3 publication Critical patent/ES2102360T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UNA SECUENCIA CDNA HUMANA QUE CODIFICA LA PROTEINA LAM-1 DE SUPERFICIE CELULAR ASOCIADA A LIMFOCITO, QUE CONTIENE DOMINIOS HOMOLOGOS CON DOMINIOS LIGADORES DE LECTINAS ANIMAL, FACTORES DE CRECIMIENTO Y PROTEINAS LIGADORAS C3/C4, Y LA PROTEINA LAM-1 CODIFICADA POR LA SECUENCIA CDNA, ES DESCUBIERTA. ANTAGONISTAS A LA LAM-1 SON USADOS EN UN METODO DE TRATAR A UN PACIENTE HUMANO QUE SUFRE DE UNA CONDICION MOVILIZADORA DE LIMFOCITO QUE CONCIERNE A ADMINISTRAR UNA CANTIDAD TERAPEUTICA DEL ANTAGONISTA EN UNA SUSTANCIA PORTADORA FARMACEUTICA NO TOXICA.
ES90301884T 1989-02-21 1990-02-21 Proteina de la superficie celular asociada a linfocitos. Expired - Lifetime ES2102360T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31310989A 1989-02-21 1989-02-21

Publications (1)

Publication Number Publication Date
ES2102360T3 true ES2102360T3 (es) 1997-08-01

Family

ID=23214421

Family Applications (2)

Application Number Title Priority Date Filing Date
ES90301884T Expired - Lifetime ES2102360T3 (es) 1989-02-21 1990-02-21 Proteina de la superficie celular asociada a linfocitos.
ES96112230T Expired - Lifetime ES2208711T3 (es) 1989-02-21 1990-02-21 Anticuerpos para proteinas de la superficie culular asociadas a linfocitos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES96112230T Expired - Lifetime ES2208711T3 (es) 1989-02-21 1990-02-21 Anticuerpos para proteinas de la superficie culular asociadas a linfocitos.

Country Status (11)

Country Link
US (3) US6020152A (es)
EP (2) EP0770680B1 (es)
JP (3) JP3367661B2 (es)
AT (2) ATE152171T1 (es)
CA (1) CA2010321C (es)
DE (2) DE69030522T2 (es)
DK (2) DK0386906T3 (es)
ES (2) ES2102360T3 (es)
GR (1) GR3024204T3 (es)
HK (2) HK1007331A1 (es)
SG (1) SG43062A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5891841A (en) * 1991-06-11 1999-04-06 The Center For Blood Research, Inc. Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof
WO1993000111A1 (en) * 1991-06-25 1993-01-07 Dana-Farber Cancer Institute Monoclonal antibody to lymphocyte-associated cell surface protein
US5869262A (en) * 1992-01-27 1999-02-09 Icos Corporation Method for monitoring an inflammatory disease state by detecting circulating ICAM-R
JP3616090B2 (ja) * 1992-01-27 2005-02-02 イコス コーポレイション 細胞間接着分子関連タンパク質
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US5316920A (en) * 1992-04-17 1994-05-31 Dana-Faber Cancer Institute, Inc. Lymphocyte activation antigen HB15, a member of the immunoglobulin superfamily
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
CA2355074A1 (en) * 1998-12-18 2000-06-29 Incyte Pharmaceuticals, Inc. Lymphocytic membrane proteins
CA2557910C (en) * 2004-04-02 2012-05-29 Amgen Inc. Methods of reducing aggregation of il-1ra

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets
US4835255A (en) * 1987-03-26 1989-05-30 Yale University T-cell membrane protein
US5389520A (en) * 1989-02-21 1995-02-14 Dana-Farber Cancer Institute, Inc. Specific detection of cell surface receptor leukocyte adhesion molecule-1
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5216131A (en) * 1989-02-23 1993-06-01 Genentech, Inc. Lymphocyte homing receptors
US5026537A (en) * 1989-04-06 1991-06-25 Centocor, Inc. Methods for imaging atherosclerotic plaque
US5227369A (en) * 1991-07-11 1993-07-13 The Regents Of The University Of California Compositions and methods for inhibiting leukocyte adhesion to cns myelin
WO1993002698A1 (en) * 1991-07-29 1993-02-18 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies to leukocyte adhesion molecule-1

Also Published As

Publication number Publication date
DE69034112D1 (de) 2003-11-27
DE69034112T2 (de) 2004-07-29
EP0770680A2 (en) 1997-05-02
SG43062A1 (en) 1997-10-17
DE69030522D1 (de) 1997-05-28
ES2208711T3 (es) 2004-06-16
JP2005230016A (ja) 2005-09-02
ATE152171T1 (de) 1997-05-15
US6020152A (en) 2000-02-01
EP0386906A1 (en) 1990-09-12
CA2010321A1 (en) 1990-08-21
US6451981B1 (en) 2002-09-17
ATE252637T1 (de) 2003-11-15
DK0770680T3 (da) 2004-02-23
JPH0322982A (ja) 1991-01-31
EP0770680B1 (en) 2003-10-22
GR3024204T3 (en) 1997-10-31
JP3367661B2 (ja) 2003-01-14
DE69030522T2 (de) 1997-12-04
EP0770680A3 (en) 1997-05-07
US5830471A (en) 1998-11-03
EP0386906B1 (en) 1997-04-23
CA2010321C (en) 2004-04-06
JP2001017189A (ja) 2001-01-23
HK1007331A1 (en) 1999-04-09
DK0386906T3 (da) 1997-10-13
HK1011050A1 (en) 1999-07-02

Similar Documents

Publication Publication Date Title
ES2102360T3 (es) Proteina de la superficie celular asociada a linfocitos.
CA1265445A (en) Composition for use in treating inflammation
FI971406A0 (fi) TIE-2-ligandeja ja menetelmiä niiden valmistamiseksi ja käyttämiseksi
LU91448I2 (fr) "panitumumab"
DK0751992T3 (da) Karendotelvækstfaktor 2
DE59009462D1 (de) Implantierbare Vorrichtung zur dosierten Abgabe von Medikamenten in den menschlichen Körper.
DE3750342D1 (de) Menschliches gamma-interferon-spezifisches Rezeptorprotein, Antikörper gegen dieses Protein, Verfahren zur Herstellung dieses Proteins und dieses Antikörpers und dieses Protein und diesen Antikörper enthaltende Zusammensetzungen.
DE68925226T2 (de) Monoklonale Antikörper
EE05558B1 (et) Antikeha v?i selle antigeeni siduva fragmendi v?i lahustuva polpeptiidi kasutamine farmatseutilise kompositsiooni valmistamiseks
EE05497B1 (et) Polüpeptiid, lahustuv CRAM-1 polüpeptiid, polünukleotiid ja antikeha
FI982745A (fi) TIE-2-reseptoriligandit (TIE-ligandi-3; TIE-ligandi-4) ja niiden käytt"
LV11816A (lv) Implantejama zalu forma
CS151887A2 (en) Method of sound, physiologically normal farming animal's mamma parenchyma's growth increase
Amagase et al. Epidermal Growth Factor Prolongs Survival Time of Tumor‐bearing Mice

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 386906

Country of ref document: ES