ES2099007A1 - Derivados de indol. - Google Patents

Derivados de indol.

Info

Publication number
ES2099007A1
ES2099007A1 ES09301604A ES9301604A ES2099007A1 ES 2099007 A1 ES2099007 A1 ES 2099007A1 ES 09301604 A ES09301604 A ES 09301604A ES 9301604 A ES9301604 A ES 9301604A ES 2099007 A1 ES2099007 A1 ES 2099007A1
Authority
ES
Spain
Prior art keywords
alkyl
alkinylene
indol derivatives
alkoxyl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301604A
Other languages
English (en)
Other versions
ES2099007B1 (es
Inventor
Graham Nigel Maw
Julian Blagg
Colin William Greengrass
Paul William Finn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Research and Development Co NV SA
Original Assignee
Pfizer Research and Development Co NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Research and Development Co NV SA filed Critical Pfizer Research and Development Co NV SA
Priority to ES9301604A priority Critical patent/ES2099007B1/es
Publication of ES2099007A1 publication Critical patent/ES2099007A1/es
Application granted granted Critical
Publication of ES2099007B1 publication Critical patent/ES2099007B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE INDOL. LOS DERIVADOS DE INDOL DE FORMULA (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE R ES H, OH, HALO, ALQUILO C1-C4 O ALCOXILO C1-C4 ; R1, R2, R3 Y R4, SON H, OH, HALO, ALQUILO C1-C4, ALCOXILO C1-C4, -CF3, -CO2(ALQUILO C1-C4), -CONH2, -CONH(ALQUILO C1-C4) O -CON(ALQUILO C1-C4); R5 ES -COOH, -COOR7, -CONR8R9 O TETRAZOL-5-ILO; R6 ES UN RADICAL 1,3-BENZODIOXOLANO; X ES O, NH, N(ALQUILO C1-C4), UN ENLACE DIRECTO O ALQUILENO C1-C4, ALQUENILENO C2-C4 O ALQUINILENO C2-C4 OPCIONALMENTE SUSTITUIDOS; Y ES METILENO, ALQUILENO C2-C6, ALQUENILENO C2-C6 O ALQUINILENO C2-C6 O UN RADICAL CON UN CICLO DE 3 A 7 ATOMOS DE C, OPCIONALMENTE SUSTITUIDOS, SON INHIBIDORES DE LA 5AL-REDUCTASA DE ESTEROIDES Y SON UTILES PARA EL TRATAMIENTO DEL ACNE VULGAR, ALOPECIA, SEBORREA, HIRSUTISMO, HIPERTROFIA PROSTATICA BENIGNA, CALVICIE ANDROGENICA Y ADENOCARCINOMA PROSTATICO HUMANO.
ES9301604A 1993-07-16 1993-07-16 Derivados de indol. Expired - Fee Related ES2099007B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301604A ES2099007B1 (es) 1993-07-16 1993-07-16 Derivados de indol.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301604A ES2099007B1 (es) 1993-07-16 1993-07-16 Derivados de indol.

Publications (2)

Publication Number Publication Date
ES2099007A1 true ES2099007A1 (es) 1997-05-01
ES2099007B1 ES2099007B1 (es) 1997-12-01

Family

ID=8282581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301604A Expired - Fee Related ES2099007B1 (es) 1993-07-16 1993-07-16 Derivados de indol.

Country Status (1)

Country Link
ES (1) ES2099007B1 (es)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843683A (en) * 1968-02-20 1974-10-22 Sterling Drug Inc Alpha-(3-(4-chlorobenzoyl)-2-methyl-6-methoxy-1-ndole)-acetic acid
US5013732A (en) * 1984-08-06 1991-05-07 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles
EP0445781A1 (en) * 1990-03-08 1991-09-11 Sterling Winthrop Inc. 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions
WO1993017014A1 (en) * 1992-02-28 1993-09-02 Pfizer Limited Indole derivatives as steroid 5 alpha-reductase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843683A (en) * 1968-02-20 1974-10-22 Sterling Drug Inc Alpha-(3-(4-chlorobenzoyl)-2-methyl-6-methoxy-1-ndole)-acetic acid
US5013732A (en) * 1984-08-06 1991-05-07 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles
EP0445781A1 (en) * 1990-03-08 1991-09-11 Sterling Winthrop Inc. 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions
WO1993017014A1 (en) * 1992-02-28 1993-09-02 Pfizer Limited Indole derivatives as steroid 5 alpha-reductase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YOUNG, T.E. y MIZIANTY, M.F.: "Biindolyls. III. Substituted 2,3'-Biindolyls from 3-arylacetylindoles." Journal of organic Chemistry, Vol. 29, 1964, pßginas 2030-2031 * Compuestos Ic,Id * *

Also Published As

Publication number Publication date
ES2099007B1 (es) 1997-12-01

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