ES2097156T3 - Procedimiento de purificacion de compuestos conjugados queladores. - Google Patents

Procedimiento de purificacion de compuestos conjugados queladores.

Info

Publication number
ES2097156T3
ES2097156T3 ES90915696T ES90915696T ES2097156T3 ES 2097156 T3 ES2097156 T3 ES 2097156T3 ES 90915696 T ES90915696 T ES 90915696T ES 90915696 T ES90915696 T ES 90915696T ES 2097156 T3 ES2097156 T3 ES 2097156T3
Authority
ES
Spain
Prior art keywords
purification
procedure
chelating compounds
labeling reagent
conjugated chelating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90915696T
Other languages
English (en)
Inventor
Ramaswamy Subramanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2097156T3 publication Critical patent/ES2097156T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Forklifts And Lifting Vehicles (AREA)
  • Paper (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

SE DESCRIBE UN METODO PARA LA EXTRACCION DE UN REACTIVO ETIQUETADOR DESUNIDO DE UNA COMPOSICION QUE COMPRENDE UN REACTIVO ETIQUETADOR UNIDO Y DESUNIDO. UN CONJUGADO MATRIZ QUELATO CAPAZ DE UNIR UN REACTIVO ETIQUETADOR DESUNIDO SE PONE EN CONTACTO CON UNA MEZCLA DE REACCION ETIQUETADORA DE BIOMOLECULA Y DESPUES SE EXTRAE LA BIOMOLECULA ETIQUETADA ESENCIALMENTE LIBRE DEL REACTIVO ETIQUETADOR DESUNIDO.
ES90915696T 1989-10-11 1990-10-10 Procedimiento de purificacion de compuestos conjugados queladores. Expired - Lifetime ES2097156T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/419,871 US5244816A (en) 1989-10-11 1989-10-11 Method for purifying chelator conjugated compounds

Publications (1)

Publication Number Publication Date
ES2097156T3 true ES2097156T3 (es) 1997-04-01

Family

ID=23664097

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90915696T Expired - Lifetime ES2097156T3 (es) 1989-10-11 1990-10-10 Procedimiento de purificacion de compuestos conjugados queladores.

Country Status (16)

Country Link
US (1) US5244816A (es)
EP (1) EP0495878B1 (es)
JP (1) JP3078575B2 (es)
KR (1) KR100206060B1 (es)
AT (1) ATE145560T1 (es)
AU (1) AU656717B2 (es)
CA (1) CA2069303A1 (es)
DE (1) DE69029274T2 (es)
DK (1) DK48892A (es)
ES (1) ES2097156T3 (es)
FI (1) FI921579A (es)
GR (1) GR3022645T3 (es)
IE (1) IE75714B1 (es)
PT (1) PT95574B (es)
WO (1) WO1991006008A1 (es)
ZA (1) ZA908095B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800802A (en) * 1989-10-11 1998-09-01 Subramanian; Ramaswamy Chelator IDAC-2
US5459040A (en) * 1993-11-22 1995-10-17 The Regents Of The University Of California Enzyme amplified, complex linked, competitive and non-competitive assays for the detection of metal ions
DE4428874A1 (de) * 1994-08-08 1996-02-22 Schering Ag Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19612650C1 (de) * 1996-04-02 1997-07-31 Evotec Biosystems Gmbh Verfahren zur Fluoreszenzmarkierung von Molekülen
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
FR2762394B1 (fr) * 1997-04-16 1999-05-28 Bio Merieux Compose ligand de coordination et utilisation pour fixer un materiel biologique
GB9800378D0 (en) * 1998-01-08 1998-03-04 Univ Liverpool Proteome analysis
FR2791582B1 (fr) * 1999-04-02 2001-06-08 Expansia Sa Utilisation d'un support polymerique acrylique en catalyse supportee
WO2001052898A1 (en) * 2000-01-21 2001-07-26 Mallinckrodt Inc. Methods for incorporating metal chelators at carboxyl-terminal site of peptides
GB0028879D0 (en) * 2000-11-27 2001-01-10 Prometic Biosciences Ltd Adsorbents and their use
WO2002098897A2 (en) 2001-06-01 2002-12-12 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
US7514078B2 (en) 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
WO2003024388A2 (en) 2001-09-20 2003-03-27 Cornell Research Foundation, Inc. Methods and compositions for treating and preventing skin disorders using binding agents specific for psma
WO2003045546A1 (en) * 2001-11-27 2003-06-05 Prometic Biosciences Ltd. The use of metal-chelating adsorbents
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
DE10350484B4 (de) * 2003-12-20 2006-02-02 Ehrfeld Mikrotechnik Bts Gmbh Verfahren und Vorrichtung zur Markierung von Proteinen
FR2886735B1 (fr) * 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
WO2014137903A2 (en) 2013-03-08 2014-09-12 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
US9993250B2 (en) * 2013-12-19 2018-06-12 Kyungpook National University Industry-Academic Cooperation Foundation Device for protecting the rectal anastomosis
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
KR20210049155A (ko) 2018-08-31 2021-05-04 젠자임 코포레이션 멸균 크로마토그래피 수지 및 제조 공정에서 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
US4283382A (en) * 1977-12-28 1981-08-11 Eastman Kodak Company Fluorescent labels comprising rare earth chelates
CA1225930A (en) * 1982-06-07 1987-08-25 Otto A. Gansow Metal chelate conjugated monoclonal antibodies
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US4775638A (en) * 1985-05-08 1988-10-04 Centocor, Inc. Single vial technique for radiolabeling protein
WO1988002635A1 (en) * 1986-10-17 1988-04-21 Cytogen Corporation Method for preparation of protein-chelator-metal ion compositions suitable for injection
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents

Also Published As

Publication number Publication date
DK48892D0 (da) 1992-04-10
AU656717B2 (en) 1995-02-16
JPH05503354A (ja) 1993-06-03
WO1991006008A1 (en) 1991-05-02
EP0495878A4 (en) 1992-09-30
FI921579A0 (fi) 1992-04-09
ATE145560T1 (de) 1996-12-15
KR920704139A (ko) 1992-12-19
US5244816A (en) 1993-09-14
EP0495878B1 (en) 1996-11-27
EP0495878A1 (en) 1992-07-29
ZA908095B (en) 1991-11-27
JP3078575B2 (ja) 2000-08-21
KR100206060B1 (ko) 1999-07-01
FI921579A (fi) 1992-04-09
PT95574A (pt) 1991-08-14
PT95574B (pt) 1997-08-29
CA2069303A1 (en) 1991-04-12
DE69029274D1 (de) 1997-01-09
DK48892A (da) 1992-04-10
DE69029274T2 (de) 1997-05-28
IE75714B1 (en) 1997-09-24
GR3022645T3 (en) 1997-05-31
IE903585A1 (en) 1991-04-24
AU6547190A (en) 1991-05-16

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