ES2095144T3 - Procedimiento mejorado para preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta. - Google Patents

Procedimiento mejorado para preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta.

Info

Publication number
ES2095144T3
ES2095144T3 ES94830151T ES94830151T ES2095144T3 ES 2095144 T3 ES2095144 T3 ES 2095144T3 ES 94830151 T ES94830151 T ES 94830151T ES 94830151 T ES94830151 T ES 94830151T ES 2095144 T3 ES2095144 T3 ES 2095144T3
Authority
ES
Spain
Prior art keywords
carnitine
preparation
waste product
improved procedure
opposite configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94830151T
Other languages
English (en)
Inventor
Fabio Giannessi
Nazareno Scafetta
Ida Bernabei
Maria Ornella Tinti
Angelis Francesco De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2095144T3 publication Critical patent/ES2095144T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA PREPARAR L-(-)-CARNITINA QUE COMPRENDE CONVERTIR D-(+)-CARNITINAMIDA A UN ESTER, ACIDIFICANDO DICHO ESTER, CONVIRTIENDO EL GRUPO ESTER A GRUPO CARBOXILO PARA OBTENER ASI D-(-)-CARNITINA, CONVIRTIENDO ESTE ULTIMO COMPUESTO A LA LACTONA DE L-(-)-CARNITINA LA CUAL TRATADA EN UN ENTORNO BASICO PRODUCE AMINOACIDO DE L-(-)-CARNITINA.
ES94830151T 1993-04-08 1994-03-31 Procedimiento mejorado para preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta. Expired - Lifetime ES2095144T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930227A IT1261231B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Publications (1)

Publication Number Publication Date
ES2095144T3 true ES2095144T3 (es) 1997-02-01

Family

ID=11401705

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94830151T Expired - Lifetime ES2095144T3 (es) 1993-04-08 1994-03-31 Procedimiento mejorado para preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta.

Country Status (13)

Country Link
US (1) US5532410A (es)
EP (1) EP0624568B1 (es)
JP (1) JP3635102B2 (es)
KR (1) KR100301952B1 (es)
AT (1) ATE145641T1 (es)
CA (1) CA2120812C (es)
DE (1) DE69400978T2 (es)
DK (1) DK0624568T3 (es)
ES (1) ES2095144T3 (es)
GR (1) GR3021790T3 (es)
IT (1) IT1261231B (es)
TW (1) TW284753B (es)
ZA (1) ZA942429B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
IT1306184B1 (it) 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti Nitrilossi derivati della (r) e (s)-carnitina.
EP2409965A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine by cycloaddition
CN108863845B (zh) * 2018-08-21 2021-01-01 湖南大学 一种肟菌酯及其中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096368A (en) * 1958-07-30 1963-07-02 Process for preparing hydrolysis products of gamma-dimethyl amin-beta-hydroxybutyroni
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
IT1191945B (it) * 1986-06-04 1988-03-31 Avantgarde Spa N-alchilammidi della d(+)-carnitina dotate di attivita' antibatterica,procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che le contengono
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.

Also Published As

Publication number Publication date
TW284753B (es) 1996-09-01
ITRM930227A1 (it) 1994-10-08
ITRM930227A0 (it) 1993-04-08
JPH06306028A (ja) 1994-11-01
ATE145641T1 (de) 1996-12-15
HK1005723A1 (en) 1999-01-22
EP0624568B1 (en) 1996-11-27
US5532410A (en) 1996-07-02
GR3021790T3 (en) 1997-02-28
DK0624568T3 (da) 1996-12-16
IT1261231B (it) 1996-05-09
DE69400978D1 (de) 1997-01-09
KR100301952B1 (ko) 2001-10-22
CA2120812A1 (en) 1994-10-09
ZA942429B (en) 1994-11-29
CA2120812C (en) 2004-10-26
JP3635102B2 (ja) 2005-04-06
DE69400978T2 (de) 1997-04-03
EP0624568A1 (en) 1994-11-17

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