ES2092969A1 - Surfactante pulmonar natural de origen porcino. - Google Patents

Surfactante pulmonar natural de origen porcino.

Info

Publication number
ES2092969A1
ES2092969A1 ES09502552A ES9502552A ES2092969A1 ES 2092969 A1 ES2092969 A1 ES 2092969A1 ES 09502552 A ES09502552 A ES 09502552A ES 9502552 A ES9502552 A ES 9502552A ES 2092969 A1 ES2092969 A1 ES 2092969A1
Authority
ES
Spain
Prior art keywords
per cent
surfactant
phospholipids
natural
phosphatidylinositol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09502552A
Other languages
English (en)
Other versions
ES2092969B1 (es
Inventor
Tapia Dahis Angeles Manzanares
Casanas Elaine Diaz
Lorenzo Wilma Caridad Alfonso
Medina Arturo Camilo Escobar
Dagnesses Hector Colome
Perez Maria Cristina Munoz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CTRO NAC SANIDAD AGROPECUARIA
Original Assignee
CTRO NAC SANIDAD AGROPECUARIA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CTRO NAC SANIDAD AGROPECUARIA filed Critical CTRO NAC SANIDAD AGROPECUARIA
Publication of ES2092969A1 publication Critical patent/ES2092969A1/es
Application granted granted Critical
Publication of ES2092969B1 publication Critical patent/ES2092969B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SURFACTANTE PULMONAR NATURAL DE ORIGEN PORCINO. EL OBJETO DE LA PRESENTE INVENCION ES UN SURFACTANTE NATURAL DE USO TERAPEUTICO OBTENIDO POR EXTRACCION ORGANICA DE LAVADOS PULMONARES DE CERDO, ASI COMO SU PROCEDIMIENTO DE OBTENCION. EL SURFACTANTE EN CUESTION CONTIENE DEL 90 POR CIENTO AL 97 POR CIENTO DE FOSFOLIPIDOS, DEL 0,5 AL 1,3 POR CIENTO DE PROTEINAS HIDROFOBAS, MAS DEL 40 POR CIENTO DE FOSFATIDIL-COLINA DISATURADA Y MAS DEL 7 POR CIENTO DE FOSFATIDIL-INOSITOL CON RESPECTO A FOSFOLIPIDOS. MAS DEL 75 POR CIENTO DE LA COMPOSICION DE ACIDOS GRASOS DE LA FOSFATIDIL-COLINA CORRESPONDE A ACIDO PALMITICO. EL CONTENIDO TOTAL DE LOS FOSFOLIPIDOS ANIONICOS (FOSFATIDIL-GLICEROL + FOSFATIDIL-INOSITOL) ES MAYOR DEL 12 POR CIENTO RESPECTO A FOSFOLIPIDOS. UNA DE SUS FORMAS FARMACEUTICAS ES UN LIOFILIZADO ESTABLE DE 2 A 8 C QUE SE RECONSTITUYE EN EL MOMENTO DE SU USO. LA APLICACION DEL SURFACTANTE POR VIA ENDOTRAQUEAL ES ADECUADA PARA EL TRATAMIENTO DEL SINDROME DE DIFICULTAD RESPIRATORIA DEL NEONATO, ASI COMO DE PACIENTES CON ESTRES RESPIRATORIO DEL ADULTO.
ES9502552A 1994-12-29 1995-12-29 Surfactante pulmonar natural de origen porcino. Expired - Fee Related ES2092969B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU1994153 1994-12-29

Publications (2)

Publication Number Publication Date
ES2092969A1 true ES2092969A1 (es) 1996-12-01
ES2092969B1 ES2092969B1 (es) 1997-07-01

Family

ID=5459462

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9502552A Expired - Fee Related ES2092969B1 (es) 1994-12-29 1995-12-29 Surfactante pulmonar natural de origen porcino.

Country Status (3)

Country Link
BR (1) BR9506114A (es)
CO (1) CO5021218A1 (es)
ES (1) ES2092969B1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035661A1 (de) * 1997-02-12 1998-08-20 Mse Pharmazeutika Gmbh Zubereitung des pulmonary surfactant zur instillation und zur oralen anwendung
GB2370505A (en) * 2000-10-26 2002-07-03 Britannia Pharmaceuticals Ltd Use of a surface active phospholipid in the manufacture of a powder medicament for the treatment of wet lung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338301A (en) * 1979-06-02 1982-07-06 Tokyo Tanabe Co., Ltd. Lung tissue extract useful for treating hyaline-membrane disease and method for producing the extract
US4397839A (en) * 1981-09-10 1983-08-09 Tokyo Tanabe Company, Limited Surface active material and process for preparing same
EP0119056A2 (en) * 1983-03-10 1984-09-19 Tokyo Tanabe Company Limited Surfactant composition and pharmaceutical compositions containing same for use in the treatment of respiratory distress syndrome
EP0286011A2 (en) * 1987-04-08 1988-10-12 CHIESI FARMACEUTICI S.p.A. Natural pulmonary surfactant, method of preparation and pharmaceutical compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338301A (en) * 1979-06-02 1982-07-06 Tokyo Tanabe Co., Ltd. Lung tissue extract useful for treating hyaline-membrane disease and method for producing the extract
US4397839A (en) * 1981-09-10 1983-08-09 Tokyo Tanabe Company, Limited Surface active material and process for preparing same
EP0119056A2 (en) * 1983-03-10 1984-09-19 Tokyo Tanabe Company Limited Surfactant composition and pharmaceutical compositions containing same for use in the treatment of respiratory distress syndrome
EP0286011A2 (en) * 1987-04-08 1988-10-12 CHIESI FARMACEUTICI S.p.A. Natural pulmonary surfactant, method of preparation and pharmaceutical compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035661A1 (de) * 1997-02-12 1998-08-20 Mse Pharmazeutika Gmbh Zubereitung des pulmonary surfactant zur instillation und zur oralen anwendung
GB2370505A (en) * 2000-10-26 2002-07-03 Britannia Pharmaceuticals Ltd Use of a surface active phospholipid in the manufacture of a powder medicament for the treatment of wet lung

Also Published As

Publication number Publication date
BR9506114A (pt) 1997-12-23
CO5021218A1 (es) 2001-03-27
ES2092969B1 (es) 1997-07-01

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