ES2092957A1 - Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica. - Google Patents

Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica.

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Publication number
ES2092957A1
ES2092957A1 ES09402436A ES9402436A ES2092957A1 ES 2092957 A1 ES2092957 A1 ES 2092957A1 ES 09402436 A ES09402436 A ES 09402436A ES 9402436 A ES9402436 A ES 9402436A ES 2092957 A1 ES2092957 A1 ES 2092957A1
Authority
ES
Spain
Prior art keywords
dichloro
antifungal activity
synthesis
substituted derivatives
preparing intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09402436A
Other languages
English (en)
Other versions
ES2092957B1 (es
Inventor
Felip Ernesto Forne
Bau Eduardo Carretero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Original Assignee
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sociedad Espanola de Especialidades Farmaco Terapeuticas SA filed Critical Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority to ES9402436A priority Critical patent/ES2092957B1/es
Publication of ES2092957A1 publication Critical patent/ES2092957A1/es
Application granted granted Critical
Publication of ES2092957B1 publication Critical patent/ES2092957B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE INTERMEDIOS PARA LA SINTESIS DE DERIVADOS DICLORO-SUSTITUIDOS CON ACTIVIDAD ANTIFUNGICA.NUEVO PROCEDIMIENTO PARA PREPARAR EL ACIDO 2-[2-(3,5-DICLOROFENIL)ETIL]BENZOICO (II), Y LA 2,4-DICLORO-10,11-DIHIDRO-5H-DIBENZO[A,D]CICLOHEPTEN-5-ONA (III), QUE COMPRENDE LA ALQUILACION DEL DIANION CON LITIO DEL ACIDO 2-METIL-BENZOICO POR UN HALOGENURO DE 3,5-DICLOROBENZILO (I) Y LA CICLACION INTRAMOLECULAR DEL ACIDO (II) ASI OBTENIDO, UTILIZANDO ACIDO POLIFOSFORICO. LA 2,4-DICLORO-10,11-DIHIDRO-5H-DIBENZO[A,D]CICLOHEPTEN-5-ONA (III) ES UTIL COMO INTERMEDIO EN LA PREPARACION DEL 1-(2,4-DICLORO-10,11-DIHIDRO-5H-DIBENZO[A,D]CICLOHEPTEN-5-I1)-1H-IMIDAZOL QUE TIENE ACTIVIDAD ANTIFUNGICA.
ES9402436A 1994-11-28 1994-11-28 Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica. Expired - Fee Related ES2092957B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9402436A ES2092957B1 (es) 1994-11-28 1994-11-28 Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9402436A ES2092957B1 (es) 1994-11-28 1994-11-28 Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica.

Publications (2)

Publication Number Publication Date
ES2092957A1 true ES2092957A1 (es) 1996-12-01
ES2092957B1 ES2092957B1 (es) 1997-08-01

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ID=8288108

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9402436A Expired - Fee Related ES2092957B1 (es) 1994-11-28 1994-11-28 Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica.

Country Status (1)

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ES (1) ES2092957B1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021838A1 (es) * 1997-10-28 1999-05-06 Laboratorios S.A.L.V.A.T., S.A. Procedimiento de preparacion del eberconazol e intermedios para el mismo
RU2560727C1 (ru) * 2014-09-22 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Способ получения 1,3-дикарбонильных соединений, содержащих дибензосуберенильный фрагмент

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104030908B (zh) * 2014-05-28 2016-01-20 健雄职业技术学院 一种2,4-二氯-10,11-二氢-5H-二苯并[a,d]环庚烯-5-酮的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2012297A6 (es) * 1989-04-10 1990-03-01 Espnola De Especialidades Farm Procedimiento para la obtencion de nuevos derivados imidazolicos diclorados con actividad antifungica.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2012297A6 (es) * 1989-04-10 1990-03-01 Espnola De Especialidades Farm Procedimiento para la obtencion de nuevos derivados imidazolicos diclorados con actividad antifungica.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
X. CIRERA. Tesis doctoral. Instituto Químico Sarriá, Barcelona, 1983, páginas 165-167 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021838A1 (es) * 1997-10-28 1999-05-06 Laboratorios S.A.L.V.A.T., S.A. Procedimiento de preparacion del eberconazol e intermedios para el mismo
RU2560727C1 (ru) * 2014-09-22 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Способ получения 1,3-дикарбонильных соединений, содержащих дибензосуберенильный фрагмент

Also Published As

Publication number Publication date
ES2092957B1 (es) 1997-08-01

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