ES2092522T3 - Excipiente con funcion doble para agentes de contraste de quelatos metalicos. - Google Patents

Excipiente con funcion doble para agentes de contraste de quelatos metalicos.

Info

Publication number
ES2092522T3
ES2092522T3 ES91106575T ES91106575T ES2092522T3 ES 2092522 T3 ES2092522 T3 ES 2092522T3 ES 91106575 T ES91106575 T ES 91106575T ES 91106575 T ES91106575 T ES 91106575T ES 2092522 T3 ES2092522 T3 ES 2092522T3
Authority
ES
Spain
Prior art keywords
excipient
metal chelate
double function
contrasting agents
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91106575T
Other languages
English (en)
Inventor
C Allen Chang
Krishan Kumar
Michael F Tweedle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24047292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2092522(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2092522T3 publication Critical patent/ES2092522T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTA UN NUEVO EXCIPIENTE DE FUNCION DOBLE PARA AGENTES DE CONTRASTE DE QUELATOS DE METAL. EL PRESENTE EXCIPIENTE, QUE ES LA SAL DE CALCIO O ZINC DEL COMPLEJO DE CALCIO O ZINC DE UN LIGADOR ORGANICO, AUMENTA LA SEGURIDAD PUESTO QUE PUEDE DESOXIDAR TANTO LOS IONES DE METAL LIBRES COMO LOS LIGADORES ORGANICOS LIBRES.
ES91106575T 1990-04-25 1991-04-24 Excipiente con funcion doble para agentes de contraste de quelatos metalicos. Expired - Lifetime ES2092522T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51446890A 1990-04-25 1990-04-25

Publications (1)

Publication Number Publication Date
ES2092522T3 true ES2092522T3 (es) 1996-12-01

Family

ID=24047292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91106575T Expired - Lifetime ES2092522T3 (es) 1990-04-25 1991-04-24 Excipiente con funcion doble para agentes de contraste de quelatos metalicos.

Country Status (8)

Country Link
EP (1) EP0454078B1 (es)
JP (1) JP3153260B2 (es)
AT (1) ATE143605T1 (es)
CA (1) CA2039399C (es)
DE (1) DE69122422T2 (es)
DK (1) DK0454078T3 (es)
ES (1) ES2092522T3 (es)
GR (1) GR3021928T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB9321595D0 (en) * 1993-10-20 1993-12-08 Nycomed Imaging As Contrast agents
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
TW319763B (es) 1995-02-01 1997-11-11 Epix Medical Inc
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6559330B1 (en) 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
KR101142730B1 (ko) * 2009-03-16 2012-05-04 가천의과학대학교 산학협력단 상자성-이노시톨 포스페이트 복합체를 이용한 자기공명영상용 조영제
DK2988756T4 (da) * 2013-04-26 2022-08-08 Guerbet Sa Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
SG11202104657RA (en) 2018-11-23 2021-06-29 Bayer Ag Formulation of contrast media and process of preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
EP0367787B2 (en) * 1987-06-30 1999-01-27 Mallinckrodt, Inc. (a Delaware corporation) Method for enhancing the safety of metal-ligand chelates as x-ray contrast agents

Also Published As

Publication number Publication date
CA2039399C (en) 2000-09-05
EP0454078A2 (en) 1991-10-30
EP0454078A3 (en) 1991-11-13
DE69122422T2 (de) 1997-02-13
DK0454078T3 (da) 1996-11-18
ATE143605T1 (de) 1996-10-15
GR3021928T3 (en) 1997-03-31
CA2039399A1 (en) 1991-10-26
EP0454078B1 (en) 1996-10-02
JP3153260B2 (ja) 2001-04-03
DE69122422D1 (de) 1996-11-07
JPH04225925A (ja) 1992-08-14

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