DE69122422D1 - Dual-Funktionnierende Excipient für Metalchelate-Kontrastmitteln - Google Patents

Dual-Funktionnierende Excipient für Metalchelate-Kontrastmitteln

Info

Publication number
DE69122422D1
DE69122422D1 DE69122422T DE69122422T DE69122422D1 DE 69122422 D1 DE69122422 D1 DE 69122422D1 DE 69122422 T DE69122422 T DE 69122422T DE 69122422 T DE69122422 T DE 69122422T DE 69122422 D1 DE69122422 D1 DE 69122422D1
Authority
DE
Germany
Prior art keywords
contrast agents
metal chelate
dual
excipient
chelate contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69122422T
Other languages
English (en)
Other versions
DE69122422T2 (de
Inventor
C Allen Chang
Krishan Kumar
Michael F Tweedle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24047292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69122422(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of DE69122422D1 publication Critical patent/DE69122422D1/de
Application granted granted Critical
Publication of DE69122422T2 publication Critical patent/DE69122422T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69122422T 1990-04-25 1991-04-24 Dual-Funktionnierende Excipient für Metalchelate-Kontrastmitteln Expired - Lifetime DE69122422T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51446890A 1990-04-25 1990-04-25

Publications (2)

Publication Number Publication Date
DE69122422D1 true DE69122422D1 (de) 1996-11-07
DE69122422T2 DE69122422T2 (de) 1997-02-13

Family

ID=24047292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69122422T Expired - Lifetime DE69122422T2 (de) 1990-04-25 1991-04-24 Dual-Funktionnierende Excipient für Metalchelate-Kontrastmitteln

Country Status (8)

Country Link
EP (1) EP0454078B1 (de)
JP (1) JP3153260B2 (de)
AT (1) ATE143605T1 (de)
CA (1) CA2039399C (de)
DE (1) DE69122422T2 (de)
DK (1) DK0454078T3 (de)
ES (1) ES2092522T3 (de)
GR (1) GR3021928T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB9321595D0 (en) * 1993-10-20 1993-12-08 Nycomed Imaging As Contrast agents
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6559330B1 (en) 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
KR101142730B1 (ko) * 2009-03-16 2012-05-04 가천의과학대학교 산학협력단 상자성-이노시톨 포스페이트 복합체를 이용한 자기공명영상용 조영제
PL2988756T5 (pl) 2013-04-26 2022-09-26 Guerbet Formulacja środka kontrastowego i powiązany sposób jego wytwarzania
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
JOP20210114A1 (ar) 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232751B1 (de) * 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-Substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
WO1989000052A1 (en) * 1987-06-30 1989-01-12 Mallinckrodt, Inc. Method for enhancing the safety of metal-ligand chelates as magnetic resonants imaging agents and x-ray contrast agents

Also Published As

Publication number Publication date
EP0454078A2 (de) 1991-10-30
EP0454078B1 (de) 1996-10-02
DK0454078T3 (da) 1996-11-18
CA2039399C (en) 2000-09-05
ES2092522T3 (es) 1996-12-01
EP0454078A3 (en) 1991-11-13
JP3153260B2 (ja) 2001-04-03
CA2039399A1 (en) 1991-10-26
GR3021928T3 (en) 1997-03-31
DE69122422T2 (de) 1997-02-13
JPH04225925A (ja) 1992-08-14
ATE143605T1 (de) 1996-10-15

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings