ES2091712B1 - Asociaciones sinergizantes que tienen un efecto antagonista de los receptores nk1 y nk2. - Google Patents

Asociaciones sinergizantes que tienen un efecto antagonista de los receptores nk1 y nk2.

Info

Publication number
ES2091712B1
ES2091712B1 ES09400092A ES9400092A ES2091712B1 ES 2091712 B1 ES2091712 B1 ES 2091712B1 ES 09400092 A ES09400092 A ES 09400092A ES 9400092 A ES9400092 A ES 9400092A ES 2091712 B1 ES2091712 B1 ES 2091712B1
Authority
ES
Spain
Prior art keywords
associations
receptors
synergizing
antagonist effect
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09400092A
Other languages
English (en)
Other versions
ES2091712A1 (es
Inventor
Claude Garret
Francois Montier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of ES2091712A1 publication Critical patent/ES2091712A1/es
Application granted granted Critical
Publication of ES2091712B1 publication Critical patent/ES2091712B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Soil Working Implements (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrotherapy Devices (AREA)

Abstract

ASOCIACIONES SINERGIZANTES QUE TIENEN UN EFECTO ANTAGONISTA DE LOS RECEPTORES NK1 Y NK2, CARACTERIZADAS PORQUE ESTAN CONSTITUIDAS POR AL MENOS UN PRODUCTO DOTADO CON UNA ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES NK1 Y POR AL MENOS UN PRODUCTO DOTADO CON UNA ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES NK2. ESTAS ASOCIACIONES SON INTERESANTES EN EL TRATAMIENTO DE LAS AFECCIONES EN LAS QUE INTERVIENEN LA SUSTANCIA P Y/O LA NEUROQUININA A.
ES09400092A 1993-01-19 1994-01-18 Asociaciones sinergizantes que tienen un efecto antagonista de los receptores nk1 y nk2. Expired - Fee Related ES2091712B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9300451A FR2700472B1 (fr) 1993-01-19 1993-01-19 Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.

Publications (2)

Publication Number Publication Date
ES2091712A1 ES2091712A1 (es) 1996-11-01
ES2091712B1 true ES2091712B1 (es) 1997-08-01

Family

ID=9443143

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09400092A Expired - Fee Related ES2091712B1 (es) 1993-01-19 1994-01-18 Asociaciones sinergizantes que tienen un efecto antagonista de los receptores nk1 y nk2.
ES94904685T Expired - Lifetime ES2100689T3 (es) 1993-01-19 1994-01-18 Asociacion sinergizante que tiene un efecto antagonista de los receptores nk1 y nk2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES94904685T Expired - Lifetime ES2100689T3 (es) 1993-01-19 1994-01-18 Asociacion sinergizante que tiene un efecto antagonista de los receptores nk1 y nk2.

Country Status (25)

Country Link
US (1) US6177450B1 (es)
EP (1) EP0680323B1 (es)
JP (1) JP4341783B2 (es)
KR (1) KR100342152B1 (es)
AT (1) ATE150972T1 (es)
AU (1) AU682166B2 (es)
BE (1) BE1006705A3 (es)
CA (1) CA2152401C (es)
CH (1) CH687503A5 (es)
DE (1) DE69402411T2 (es)
DK (1) DK0680323T3 (es)
ES (2) ES2091712B1 (es)
FR (1) FR2700472B1 (es)
GB (1) GB2274777B (es)
GR (1) GR3023021T3 (es)
IE (1) IE940035A1 (es)
IL (1) IL108356A (es)
IT (1) IT1269185B (es)
LU (1) LU88442A1 (es)
NO (1) NO315077B1 (es)
NZ (1) NZ259728A (es)
PT (1) PT101444A (es)
TW (1) TW381021B (es)
WO (1) WO1994016697A1 (es)
ZA (1) ZA94333B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2287404A (en) * 1994-03-15 1995-09-20 Pfizer Antiinflammatory and analgesic compositions
EP0790825A1 (en) * 1994-11-10 1997-08-27 Pfizer Inc. Nk-1 receptor antagonists for the treatment of eye disorders
US5696267A (en) * 1995-05-02 1997-12-09 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
US5688960A (en) * 1995-05-02 1997-11-18 Schering Corporation Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
FR2738245B1 (fr) * 1995-08-28 1997-11-21 Sanofi Sa Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
US5789422A (en) * 1996-10-28 1998-08-04 Schering Corporation Substituted arylalkylamines as neurokinin antagonists
ATE282417T1 (de) * 1996-12-02 2004-12-15 Merck Sharp & Dohme Die verwendung von nk-1 rezeptor antagonisten für die behandlung von bewegungsstörungen
US6156749A (en) * 1997-12-01 2000-12-05 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating movement disorders
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
FR2792835B3 (fr) 1999-04-27 2001-05-25 Sanofi Sa Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
US20100189797A1 (en) 2002-06-10 2010-07-29 Julien Mendlewicz Oral antidepressant formulation
JP2007509184A (ja) * 2003-10-27 2007-04-12 ノバルティス アクチエンゲゼルシャフト 尿失禁の処置におけるニューロキニンアンタゴニストの使用
CN101065014A (zh) * 2004-09-23 2007-10-31 亚历山大·米哈洛 通过诱导逆适应调节神经递质系统的方法
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164372A (en) 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
FI97540C (fi) 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
GB8929070D0 (en) 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5232929A (en) 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
FR2678267B1 (fr) 1991-06-25 1994-02-04 Elf Sanofi Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
GB9023116D0 (en) 1990-10-24 1990-12-05 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
DE69220258T2 (de) 1991-02-11 1997-12-18 Merck Sharp & Dohme Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
FR2677361A1 (fr) * 1991-06-04 1992-12-11 Adir Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP0668770A1 (en) 1991-04-24 1995-08-30 Warner-Lambert Company $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO1993000331A1 (en) 1991-06-20 1993-01-07 Pfizer Inc. Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
TW202432B (es) 1991-06-21 1993-03-21 Pfizer
US5288730A (en) 1991-06-24 1994-02-22 Merck Sharp & Dohme Limited Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
EP0536817A1 (en) 1991-07-05 1993-04-14 MERCK SHARP & DOHME LTD. Azabicyclic compounds as tachykinin antagonists
WO1993001169A2 (en) 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
US5629347A (en) 1991-07-05 1997-05-13 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
US5610183A (en) 1991-07-10 1997-03-11 Merck, Sharp & Dohme Ltd. Phenylglycine derivatives pharmaceutical compositions containing them and their use in therapy
WO1993001159A1 (en) 1991-07-10 1993-01-21 Merck Sharp & Dohme Limited Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
US5459270A (en) 1991-08-20 1995-10-17 Merck Sharp & Dohme Limited Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them
PT533280E (pt) 1991-09-20 2001-01-31 Glaxo Group Ltd Novas utilizacoes medicas para antagonistas de taquiquinina
DK0607164T3 (da) 1991-09-26 2002-06-17 Pfizer Kondenserede tricykliske nitrogenholdige heterocykliske forbindelser som substans P-receptorantagonister
JP2553020B2 (ja) 1991-11-07 1996-11-13 吉富製薬株式会社 キヌクリジン化合物およびその医薬用途
EP0613458B1 (en) 1991-11-12 1998-01-07 Pfizer Inc. Acyclic ethylenediamine derivatives as substance p receptor antagonists
CA2083891A1 (en) 1991-12-03 1993-06-04 Angus Murray Macleod Heterocyclic compounds, compositions containing them and their use in therapy
GB9201179D0 (en) 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
US5328927A (en) 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
JP2656702B2 (ja) 1992-03-23 1997-09-24 ファイザー製薬株式会社 ペプチド性キヌクリジン
FR2689888B1 (fr) 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
JPH07505648A (ja) 1992-04-15 1995-06-22 メルク　シヤープ　エンド　ドーム　リミテツド アザサイクリック化合物
EP0641328B1 (en) 1992-05-18 2001-11-21 Pfizer Inc. Bridged aza-bicyclic derivatives as substance p antagonists

Also Published As

Publication number Publication date
BE1006705A3 (fr) 1994-11-22
IE940035A1 (en) 1994-07-27
NO952828L (no) 1995-07-17
KR960700056A (ko) 1996-01-19
NO315077B1 (no) 2003-07-07
LU88442A1 (fr) 1994-10-03
DK0680323T3 (da) 1997-10-20
ES2100689T3 (es) 1997-06-16
ITMI940039A0 (it) 1994-01-14
ITMI940039A1 (it) 1995-07-14
DE69402411T2 (de) 1997-10-30
EP0680323A1 (fr) 1995-11-08
CA2152401C (fr) 2008-08-26
CH687503A5 (fr) 1996-12-31
DE69402411D1 (de) 1997-05-07
ES2091712A1 (es) 1996-11-01
IT1269185B (it) 1997-03-21
US6177450B1 (en) 2001-01-23
KR100342152B1 (ko) 2003-02-26
JP4341783B2 (ja) 2009-10-07
FR2700472A1 (fr) 1994-07-22
IL108356A (en) 1998-09-24
CA2152401A1 (fr) 1994-08-04
GB2274777A (en) 1994-08-10
FR2700472B1 (fr) 1995-02-17
JPH08505637A (ja) 1996-06-18
EP0680323B1 (fr) 1997-04-02
AU5862794A (en) 1994-08-15
TW381021B (en) 2000-02-01
ATE150972T1 (de) 1997-04-15
NO952828D0 (no) 1995-07-17
GR3023021T3 (en) 1997-07-30
ZA94333B (en) 1994-09-02
PT101444A (pt) 1994-10-31
NZ259728A (en) 1996-05-28
GB2274777B (en) 1996-10-02
AU682166B2 (en) 1997-09-25
IL108356A0 (en) 1994-04-12
GB9400691D0 (en) 1994-03-09
WO1994016697A1 (fr) 1994-08-04

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