ES2090147T3 - Emulsion de grasa. - Google Patents

Emulsion de grasa.

Info

Publication number
ES2090147T3
ES2090147T3 ES90917270T ES90917270T ES2090147T3 ES 2090147 T3 ES2090147 T3 ES 2090147T3 ES 90917270 T ES90917270 T ES 90917270T ES 90917270 T ES90917270 T ES 90917270T ES 2090147 T3 ES2090147 T3 ES 2090147T3
Authority
ES
Spain
Prior art keywords
emulsion
polyene antifungal
simple lipid
fat emulsion
antifungal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917270T
Other languages
English (en)
Inventor
Junzo Seki
Kouichi Ushimaru
Makoto Sugiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Application granted granted Critical
Publication of ES2090147T3 publication Critical patent/ES2090147T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Edible Oils And Fats (AREA)

Abstract

UNA EMULSION DE GRASAS DESARROLLADA PARA SOLUCIONAR LOS INCONVENIENTES DE ANTIBIOTICOS ANTIFUNGICOS DE POLIENO QUE TIENEN TAL TOXICIDAD CONSIDERABLE QUE HAY QUE LIMITAR LA GAMA DE ADMINISTRACION DE LOS MISMOS CONCIBIENDO ADECUADAMENTE LA FORMA DE ADMINISTRACION, REDUCIENDO ASI LA TOXICIDAD HEMOLITICA Y NEFROTOXICIDAD Y FACILITANDO LA MIGRACION DE UNA MEDICINA HACIA PARTES INFECTADAS, SIN AFECTAR CONTRARIAMENTE A LA ACCION FARMACOLOGICA (ACCION ANTIFUNGICA) SOBRE UN NIVEL MOLECULAR. LA EMULSION COMPRENDE DE 0''005 A 5 % DE UN ANTIBIOTICO ANTIFUNGICO DE POLIENO, 0''5 A 30 % DE UN LIPIDO SIMPLE, Y UN FOSFOLIPIDO, EN UNA CANTIDAD DE 0''15 A 2 VECES TAN GRANDE COMO EL LIPIDO SIMPLE, EN EL QUE LA PROPORCION RELATIVA DE CADA INGREDIENTE SE CONTROLA PARA OBTENER UNA MICROEMULSION FINA DE UN DIAMETRO MEDIO DE PARTICULAS DE, AL MENOS, 10 NM HASTA 100 NM. ESTA EMULSION PUEDE REFORZAR CONSIDERABLEMENTE LA EFICACIA DE ANTIBIOTICOS ANTIFUNGICOS DE POLIENO TALES COMO AMFOTERICINA B, Y ES MUY UTIL PARA EL DESARROLLO DE MEDICINAS.
ES90917270T 1989-11-27 1990-11-26 Emulsion de grasa. Expired - Lifetime ES2090147T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30862289 1989-11-27

Publications (1)

Publication Number Publication Date
ES2090147T3 true ES2090147T3 (es) 1996-10-16

Family

ID=17983265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917270T Expired - Lifetime ES2090147T3 (es) 1989-11-27 1990-11-26 Emulsion de grasa.

Country Status (8)

Country Link
EP (1) EP0598116B1 (es)
JP (1) JP2653245B2 (es)
KR (1) KR0151704B1 (es)
AT (1) ATE140622T1 (es)
CA (1) CA2069635C (es)
DE (1) DE69027941T2 (es)
ES (1) ES2090147T3 (es)
WO (1) WO1991007973A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5843470A (en) 1995-10-06 1998-12-01 Mdv Technologies, Inc. Method and composition for inhibiting post-surgical adhesions
EP1039932A1 (en) * 1997-12-23 2000-10-04 Alliance Pharmaceutical Corporation Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
DE19825856A1 (de) * 1998-06-10 1999-12-16 Labtec Gmbh Topische Arzneimittelzubereitung
IT1301807B1 (it) * 1998-06-25 2000-07-07 Tiberio Bruzzese Formulazioni farmaceutiche iniettabili di derivati della partricina.
GB2511028A (en) * 2012-12-18 2014-08-27 Univ Manchester Metropolitan Nano emulsions, methods of forming the same and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58222014A (ja) * 1982-06-18 1983-12-23 Taisho Pharmaceut Co Ltd プロスタグランジンｅ↓１脂肪乳剤
JPS59141518A (ja) * 1983-02-03 1984-08-14 Taisho Pharmaceut Co Ltd プロスタグランジン脂肪乳剤
JPS59216820A (ja) * 1983-05-20 1984-12-06 Taisho Pharmaceut Co Ltd プロスタグランジン脂肪乳剤
US4707470A (en) * 1985-05-17 1987-11-17 Smithkline Beckman Corporation Polyene antibiotic emulsion formulation
JPS61291512A (ja) * 1985-06-19 1986-12-22 Kao Corp 皮膚料
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
DE3625169A1 (de) * 1986-07-25 1988-01-28 Bayer Ag Verwendung von haertbaren reaktionsmassen zur herstellung von datentraegern
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
US4925678A (en) * 1987-04-01 1990-05-15 Ranney David F Endothelial envelopment drug carriers
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
GB8714652D0 (en) * 1987-06-23 1987-07-29 Davis S S Drug emulsion
AU598958B2 (en) * 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation

Also Published As

Publication number Publication date
EP0598116A4 (en) 1992-07-30
DE69027941T2 (de) 1997-01-23
DE69027941D1 (de) 1996-08-29
JP2653245B2 (ja) 1997-09-17
WO1991007973A1 (fr) 1991-06-13
CA2069635A1 (en) 1991-05-28
ATE140622T1 (de) 1996-08-15
KR0151704B1 (ko) 1998-10-15
EP0598116A1 (en) 1994-05-25
KR920703070A (ko) 1992-12-17
CA2069635C (en) 1998-05-05
EP0598116B1 (en) 1996-07-24

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