ES2080656A1 - Fluorinated hydroxyalkylquinoline acids as leucotriene antagonists - Google Patents

Fluorinated hydroxyalkylquinoline acids as leucotriene antagonists

Info

Publication number
ES2080656A1
ES2080656A1 ES09301617A ES9301617A ES2080656A1 ES 2080656 A1 ES2080656 A1 ES 2080656A1 ES 09301617 A ES09301617 A ES 09301617A ES 9301617 A ES9301617 A ES 9301617A ES 2080656 A1 ES2080656 A1 ES 2080656A1
Authority
ES
Spain
Prior art keywords
fluorinated
leucotriene
antagonists
leucotriene antagonists
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301617A
Other languages
Spanish (es)
Other versions
ES2080656B1 (en
Inventor
Robert Zamboni
Daniel Guay
Marc Labelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Priority to ES9301617A priority Critical patent/ES2080656B1/en
Publication of ES2080656A1 publication Critical patent/ES2080656A1/en
Application granted granted Critical
Publication of ES2080656B1 publication Critical patent/ES2080656B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Fluorinated hydroxyalkylquinoline acids as leucotriene antagonists. The invention provides compounds of formula I in which R1 is 6-F or 6,7-F2 or their pharmaceutically acceptable salts the compounds are leucotriene antagonists and inhibitors of the biosynthesis of leucotriene. These compounds are useful as antiasthmatic, antiallergenic, antiinflammatory and cytoprotective agents. They are also useful for the treatment of angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxaemia, uveitis and the rejection of implants.
ES9301617A 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. Expired - Fee Related ES2080656B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301617A ES2080656B1 (en) 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301617A ES2080656B1 (en) 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.

Publications (2)

Publication Number Publication Date
ES2080656A1 true ES2080656A1 (en) 1996-02-01
ES2080656B1 ES2080656B1 (en) 1996-10-16

Family

ID=8282597

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301617A Expired - Fee Related ES2080656B1 (en) 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.

Country Status (1)

Country Link
ES (1) ES2080656B1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0399818A1 (en) * 1989-05-24 1990-11-28 Merck Frosst Canada Inc. Diarylstyrylquinoline diacids
EP0480716A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0480717A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0565185A1 (en) * 1992-04-10 1993-10-13 Merck Frosst Canada Inc. Quinoline derivatives as leukotriene antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0399818A1 (en) * 1989-05-24 1990-11-28 Merck Frosst Canada Inc. Diarylstyrylquinoline diacids
EP0480716A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0480717A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0565185A1 (en) * 1992-04-10 1993-10-13 Merck Frosst Canada Inc. Quinoline derivatives as leukotriene antagonists

Also Published As

Publication number Publication date
ES2080656B1 (en) 1996-10-16

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