ES2080656A1 - Fluorinated hydroxyalkylquinoline acids as leucotriene antagonists - Google Patents
Fluorinated hydroxyalkylquinoline acids as leucotriene antagonistsInfo
- Publication number
- ES2080656A1 ES2080656A1 ES09301617A ES9301617A ES2080656A1 ES 2080656 A1 ES2080656 A1 ES 2080656A1 ES 09301617 A ES09301617 A ES 09301617A ES 9301617 A ES9301617 A ES 9301617A ES 2080656 A1 ES2080656 A1 ES 2080656A1
- Authority
- ES
- Spain
- Prior art keywords
- fluorinated
- leucotriene
- antagonists
- leucotriene antagonists
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Fluorinated hydroxyalkylquinoline acids as leucotriene antagonists. The invention provides compounds of formula I in which R1 is 6-F or 6,7-F2 or their pharmaceutically acceptable salts the compounds are leucotriene antagonists and inhibitors of the biosynthesis of leucotriene. These compounds are useful as antiasthmatic, antiallergenic, antiinflammatory and cytoprotective agents. They are also useful for the treatment of angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxaemia, uveitis and the rejection of implants.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301617A ES2080656B1 (en) | 1993-07-19 | 1993-07-19 | FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301617A ES2080656B1 (en) | 1993-07-19 | 1993-07-19 | FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2080656A1 true ES2080656A1 (en) | 1996-02-01 |
ES2080656B1 ES2080656B1 (en) | 1996-10-16 |
Family
ID=8282597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9301617A Expired - Fee Related ES2080656B1 (en) | 1993-07-19 | 1993-07-19 | FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2080656B1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0399818A1 (en) * | 1989-05-24 | 1990-11-28 | Merck Frosst Canada Inc. | Diarylstyrylquinoline diacids |
EP0480716A1 (en) * | 1990-10-12 | 1992-04-15 | Merck Frosst Canada Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0480717A1 (en) * | 1990-10-12 | 1992-04-15 | Merck Frosst Canada Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0565185A1 (en) * | 1992-04-10 | 1993-10-13 | Merck Frosst Canada Inc. | Quinoline derivatives as leukotriene antagonists |
-
1993
- 1993-07-19 ES ES9301617A patent/ES2080656B1/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0399818A1 (en) * | 1989-05-24 | 1990-11-28 | Merck Frosst Canada Inc. | Diarylstyrylquinoline diacids |
EP0480716A1 (en) * | 1990-10-12 | 1992-04-15 | Merck Frosst Canada Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0480717A1 (en) * | 1990-10-12 | 1992-04-15 | Merck Frosst Canada Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0565185A1 (en) * | 1992-04-10 | 1993-10-13 | Merck Frosst Canada Inc. | Quinoline derivatives as leukotriene antagonists |
Also Published As
Publication number | Publication date |
---|---|
ES2080656B1 (en) | 1996-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19930719 Kind code of ref document: B1 Effective date: 19930719 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20180806 |