ES2080656B1 - FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. - Google Patents
FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.Info
- Publication number
- ES2080656B1 ES2080656B1 ES9301617A ES9301617A ES2080656B1 ES 2080656 B1 ES2080656 B1 ES 2080656B1 ES 9301617 A ES9301617 A ES 9301617A ES 9301617 A ES9301617 A ES 9301617A ES 2080656 B1 ES2080656 B1 ES 2080656B1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxyalkylkinoline
- fluorated
- acids
- compounds
- leucotrene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
ACIDOS DE HIDROXIALQUILQUINOLINA FLUORADOS COMO ANTAGONISTAS DEL LEUCOTRIENO. LA INVENCION PROPORCIONA COMPUESTOS DE FORMULA I, EN LA QUE R1 ES 6-F O 6,7-F2 O SUS SALES FARMACEUTICAMENTE ACEPTABLES: LOS COMPUESTOS SON ANTAGONISTAS DE LEUCOTRIENO E INHIBIDORES DE BIOSINTESIS DE LEUCOTRIENO. ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTIASMATICOS, ANTIALERGICOS, ANTIINFLAMATORIOS Y CITOPROTECTORES. TAMBIEN SON UTILES PARA EL TRATAMIENTO DE ANGINA, ESPASMO CEREBRAL, NEFRITIS GLOMERULAR, HEPATITIS, ENDOTOXEMIA, UVEITIS Y RECHAZO DE ALOINJERTO.FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. THE INVENTION PROVIDES FORMULA I COMPOUNDS, IN WHICH R1 IS 6-F OR 6,7-F2 OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS: THE COMPOUNDS ARE LEUCOTRENE ANTAGONISTS AND LEUKOTRIENE BIOSYNTHESIS INHIBITORS. THESE COMPOUNDS ARE USEFUL AS ANTI-ASMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND CYTOPROTECTORS AGENTS. THEY ARE ALSO USEFUL FOR THE TREATMENT OF ANGINA, BRAIN SPASM, GLOMERULAR NEPHRITIS, HEPATITIS, ENDOTOXEMIA, UVEITIS AND ALLOGAR REJECTION.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301617A ES2080656B1 (en) | 1993-07-19 | 1993-07-19 | FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301617A ES2080656B1 (en) | 1993-07-19 | 1993-07-19 | FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2080656A1 ES2080656A1 (en) | 1996-02-01 |
ES2080656B1 true ES2080656B1 (en) | 1996-10-16 |
Family
ID=8282597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9301617A Expired - Fee Related ES2080656B1 (en) | 1993-07-19 | 1993-07-19 | FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2080656B1 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ233752A (en) * | 1989-05-24 | 1993-05-26 | Merck Frosst Canada Inc | Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof |
US5428033A (en) * | 1990-10-12 | 1995-06-27 | Merck Frosst Canada, Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
CA2053209C (en) * | 1990-10-12 | 1998-12-08 | Michel L. Belley | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5270324A (en) * | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
-
1993
- 1993-07-19 ES ES9301617A patent/ES2080656B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2080656A1 (en) | 1996-02-01 |
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Date of ref document: 19930719 Kind code of ref document: B1 Effective date: 19930719 |
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