ES2080656B1 - FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. - Google Patents

FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.

Info

Publication number
ES2080656B1
ES2080656B1 ES9301617A ES9301617A ES2080656B1 ES 2080656 B1 ES2080656 B1 ES 2080656B1 ES 9301617 A ES9301617 A ES 9301617A ES 9301617 A ES9301617 A ES 9301617A ES 2080656 B1 ES2080656 B1 ES 2080656B1
Authority
ES
Spain
Prior art keywords
hydroxyalkylkinoline
fluorated
acids
compounds
leucotrene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9301617A
Other languages
Spanish (es)
Other versions
ES2080656A1 (en
Inventor
Robert Zamboni
Daniel Guay
Marc Labelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Priority to ES9301617A priority Critical patent/ES2080656B1/en
Publication of ES2080656A1 publication Critical patent/ES2080656A1/en
Application granted granted Critical
Publication of ES2080656B1 publication Critical patent/ES2080656B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ACIDOS DE HIDROXIALQUILQUINOLINA FLUORADOS COMO ANTAGONISTAS DEL LEUCOTRIENO. LA INVENCION PROPORCIONA COMPUESTOS DE FORMULA I, EN LA QUE R1 ES 6-F O 6,7-F2 O SUS SALES FARMACEUTICAMENTE ACEPTABLES: LOS COMPUESTOS SON ANTAGONISTAS DE LEUCOTRIENO E INHIBIDORES DE BIOSINTESIS DE LEUCOTRIENO. ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTIASMATICOS, ANTIALERGICOS, ANTIINFLAMATORIOS Y CITOPROTECTORES. TAMBIEN SON UTILES PARA EL TRATAMIENTO DE ANGINA, ESPASMO CEREBRAL, NEFRITIS GLOMERULAR, HEPATITIS, ENDOTOXEMIA, UVEITIS Y RECHAZO DE ALOINJERTO.FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. THE INVENTION PROVIDES FORMULA I COMPOUNDS, IN WHICH R1 IS 6-F OR 6,7-F2 OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS: THE COMPOUNDS ARE LEUCOTRENE ANTAGONISTS AND LEUKOTRIENE BIOSYNTHESIS INHIBITORS. THESE COMPOUNDS ARE USEFUL AS ANTI-ASMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND CYTOPROTECTORS AGENTS. THEY ARE ALSO USEFUL FOR THE TREATMENT OF ANGINA, BRAIN SPASM, GLOMERULAR NEPHRITIS, HEPATITIS, ENDOTOXEMIA, UVEITIS AND ALLOGAR REJECTION.

ES9301617A 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS. Expired - Fee Related ES2080656B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301617A ES2080656B1 (en) 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301617A ES2080656B1 (en) 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.

Publications (2)

Publication Number Publication Date
ES2080656A1 ES2080656A1 (en) 1996-02-01
ES2080656B1 true ES2080656B1 (en) 1996-10-16

Family

ID=8282597

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301617A Expired - Fee Related ES2080656B1 (en) 1993-07-19 1993-07-19 FLUORATED HYDROXYALKYLKINOLINE ACIDS AS LEUCOTRENE ANTAGONISTS.

Country Status (1)

Country Link
ES (1) ES2080656B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof
US5428033A (en) * 1990-10-12 1995-06-27 Merck Frosst Canada, Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
CA2053209C (en) * 1990-10-12 1998-12-08 Michel L. Belley Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists

Also Published As

Publication number Publication date
ES2080656A1 (en) 1996-02-01

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