ES2079315A1 - Nuevas imidazopiridinas. - Google Patents

Nuevas imidazopiridinas.

Info

Publication number
ES2079315A1
ES2079315A1 ES09400364A ES9400364A ES2079315A1 ES 2079315 A1 ES2079315 A1 ES 2079315A1 ES 09400364 A ES09400364 A ES 09400364A ES 9400364 A ES9400364 A ES 9400364A ES 2079315 A1 ES2079315 A1 ES 2079315A1
Authority
ES
Spain
Prior art keywords
alkyl
aryl
cycloalkyl
angiotensin
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400364A
Other languages
English (en)
Other versions
ES2079315B1 (es
Inventor
Carmen Almansa
Elena Carceller
Concepcion Gonzalez
M Carmen Torres
Javier Bartroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES09400364A priority Critical patent/ES2079315B1/es
Priority to CA002143412A priority patent/CA2143412A1/en
Priority to MX9501084A priority patent/MX9501084A/es
Priority to NO950684A priority patent/NO304378B1/no
Priority to KR1019950003690A priority patent/KR950032190A/ko
Priority to US08/393,981 priority patent/US5554624A/en
Priority to EP95102658A priority patent/EP0669333A1/en
Priority to JP7061678A priority patent/JPH07267951A/ja
Publication of ES2079315A1 publication Critical patent/ES2079315A1/es
Application granted granted Critical
Publication of ES2079315B1 publication Critical patent/ES2079315B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVAS IMIDAZOPIRIDINAS. COMPUESTOS DE FORMULA I Y SUS SALES Y SOLVATOS, EN DONDE R1 SIGNIFICA C1-4 ALQUILO O C3-7 CICLOALQUILO; AR1 REPRESENTA FENILO O PIRIDINA QUE PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS; AR2 REPRESENTA C3-7 CICLOALQUILO, FENILO OPCIONALMENTE SUSTITUIDO O HETEROCICLO; LA AGRUPACION X-Y REPRESENTA C=C O BIEN CH-CH; Z REPRESENTA, ENTRE OTROS, -CO2H O -TETRAZOL-5-IL; W REPRESENTA HIDROGENO, CIANO, C1-4 ALQUILO, CONHR5, AR2, C1-4 ALQUILSULFONIL, C1-4 ALQUILSULFINIL, C1-4 ALQUILTIO, C1-4 ALCOXI, C1-4 ALQUILCARBONIL, HALOGENO, HALOMETILO, HIDROXIMETILO O C1-4 ALCOXIMETILO O BIEN PUEDE REPRESENTAR CUALQUIERA DE LOS SIGNIFICADOS DE Z; Y R5 REPRESENTA HIDROGENO, C1-4 ALQUILO, ARILO O ARIL-(C1-4)ALQUILO. DICHOS COMPUESTOS SON UTILES COMO ANTAGONISTAS DE LA ANGIOTENSINA II. LA PRESENTE INVENCION DESCRIBE TAMBIEN PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES09400364A 1994-02-24 1994-02-24 Nuevas imidazopiridinas. Expired - Fee Related ES2079315B1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES09400364A ES2079315B1 (es) 1994-02-24 1994-02-24 Nuevas imidazopiridinas.
MX9501084A MX9501084A (es) 1994-02-24 1995-02-23 Nuevas imidazopiridinas con actividad antagonista de la angiotensina ii.
NO950684A NO304378B1 (no) 1994-02-24 1995-02-23 Nye imidazopyridinderivater som er angiotensin II-antagonister, farmas°ytiske preparater som inneholder dem, og deres anvendelse til fremstilling av medikamenter
CA002143412A CA2143412A1 (en) 1994-02-24 1995-02-23 Imidazopyridine derivatives as angiotensin ii antagonists
KR1019950003690A KR950032190A (ko) 1994-02-24 1995-02-24 안지오텐신 ii 길항제로서의 신규 이미다조피리딘 유도체
US08/393,981 US5554624A (en) 1994-02-24 1995-02-24 Imidazopyridine derivatives as angiotensin II antagonists
EP95102658A EP0669333A1 (en) 1994-02-24 1995-02-24 New imidazopyridine derivatives as angiotensin II antagonists
JP7061678A JPH07267951A (ja) 1994-02-24 1995-02-24 アンジオテンシンｉｉ拮抗剤としての新規イミダゾピリジン誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09400364A ES2079315B1 (es) 1994-02-24 1994-02-24 Nuevas imidazopiridinas.

Publications (2)

Publication Number Publication Date
ES2079315A1 true ES2079315A1 (es) 1996-01-01
ES2079315B1 ES2079315B1 (es) 1996-10-16

Family

ID=8285334

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400364A Expired - Fee Related ES2079315B1 (es) 1994-02-24 1994-02-24 Nuevas imidazopiridinas.

Country Status (8)

Country Link
US (1) US5554624A (es)
EP (1) EP0669333A1 (es)
JP (1) JPH07267951A (es)
KR (1) KR950032190A (es)
CA (1) CA2143412A1 (es)
ES (1) ES2079315B1 (es)
MX (1) MX9501084A (es)
NO (1) NO304378B1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465484B1 (en) * 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
TR200200515T2 (tr) * 1999-08-30 2002-11-21 Aventis Pharma Deutschland Gmbh Renin-anjiyotensin sistem önleyicilerinin kardiyovasküler vakaların engellenmesinde kullanılması.
JPWO2005011736A1 (ja) * 2003-07-30 2006-09-14 株式会社 東北テクノアーチ アルツハイマー病の予防および／または治療剤
JP4866723B2 (ja) * 2004-02-26 2012-02-01 協和発酵キリン株式会社 好中球性炎症疾患の予防及び／または治療剤
WO2006076706A1 (en) * 2005-01-14 2006-07-20 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
US20090291942A1 (en) * 2008-05-26 2009-11-26 Ivan Cornella Taracido Imidazo pyridine derivatives
WO2011138657A1 (en) * 2010-05-04 2011-11-10 Glenmark Pharmaceuticals S.A. Aryl substituted olefinic compounds as pde10a inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011999A1 (en) * 1990-02-13 1991-08-22 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted benzyl element
DE4142366A1 (de) * 1991-07-15 1993-06-24 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5240938A (en) * 1991-02-13 1993-08-31 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011999A1 (en) * 1990-02-13 1991-08-22 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted benzyl element
US5240938A (en) * 1991-02-13 1993-08-31 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring
DE4142366A1 (de) * 1991-07-15 1993-06-24 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0669333A1 (en) 1995-08-30
NO950684L (no) 1995-08-25
CA2143412A1 (en) 1995-08-25
NO304378B1 (no) 1998-12-07
KR950032190A (ko) 1995-12-20
MX9501084A (es) 1997-10-31
ES2079315B1 (es) 1996-10-16
US5554624A (en) 1996-09-10
JPH07267951A (ja) 1995-10-17
NO950684D0 (no) 1995-02-23

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