ES2076096A1 - Compuestos inhibidores de la enzima convertidora de angiotensinas y dela peptidasa neutra, y metodos para prepararlos. - Google Patents
Compuestos inhibidores de la enzima convertidora de angiotensinas y dela peptidasa neutra, y metodos para prepararlos.Info
- Publication number
- ES2076096A1 ES2076096A1 ES09301577A ES9301577A ES2076096A1 ES 2076096 A1 ES2076096 A1 ES 2076096A1 ES 09301577 A ES09301577 A ES 09301577A ES 9301577 A ES9301577 A ES 9301577A ES 2076096 A1 ES2076096 A1 ES 2076096A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- preparing
- methods
- neutral endopeptidase
- inhibiting angiotensin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPUESTOS INHIBIDORES DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINAS Y DE LA ENDOPEPTIDASA NEUTRA, Y METODOS PARA PREPARARLOS. LOS COMPUESTOS TIENEN LA FORMULA: *FIG* EN DONDE R1, R2 Y R19 SE SELECCIONAN ENTRE HIDROGENO Y RADICALES ORGANICOS, X1 SE SELECCIONA ENTRE DIVERSOS RADICALES ORGANICOS Y "N" ES 0 O 1, DEBIENDO SER FORZOSAMENTE 1 CUANDO R2 Y R19 SON AMBOS DISTINTOS DE HIDROGENO. ESTOS COMPUESTOS SE PREPARAN SIGUIENDO, ENTRE OTRAS, LA VIA DE COPULAR UN ACIDO ACILMERCAPTOCARBOXILICO O UNA FORMA ACTIVADA DEL MISMO CON UN COMPUESTO DE FORMULA H-X1, OBTENIENDOSE UN COMPUESTO QUE INCLUYE UN GRUPO PROTECTOR DE ESTER FACILMENTE SEPARABLE Y UN GRUPO ACILO, LOS CUALES SON LUEGO ELIMINADOS PARA DAR EL COMPUESTO BUSCADO. LOS COMPUESTOS DE LA INVENCION SON UTILES COMO AGENTES CARDIOVASCULARES.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09301577A ES2076096B1 (es) | 1993-07-14 | 1993-07-14 | Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09301577A ES2076096B1 (es) | 1993-07-14 | 1993-07-14 | Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2076096A1 true ES2076096A1 (es) | 1995-10-16 |
ES2076096B1 ES2076096B1 (es) | 1996-03-16 |
Family
ID=8282546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09301577A Expired - Fee Related ES2076096B1 (es) | 1993-07-14 | 1993-07-14 | Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2076096B1 (es) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0481522A1 (en) * | 1990-10-18 | 1992-04-22 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
EP0599444A1 (en) * | 1992-05-18 | 1994-06-01 | E.R. SQUIBB & SONS, INC. | Dual action inhibitors |
-
1993
- 1993-07-14 ES ES09301577A patent/ES2076096B1/es not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0481522A1 (en) * | 1990-10-18 | 1992-04-22 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
EP0599444A1 (en) * | 1992-05-18 | 1994-06-01 | E.R. SQUIBB & SONS, INC. | Dual action inhibitors |
Also Published As
Publication number | Publication date |
---|---|
ES2076096B1 (es) | 1996-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20100315 |