ES2070089B1 - SOLUTION OF PERFUSION, CONSERVATION AND REPERFUSION OF ORGANS. - Google Patents
SOLUTION OF PERFUSION, CONSERVATION AND REPERFUSION OF ORGANS.Info
- Publication number
- ES2070089B1 ES2070089B1 ES09301971A ES9301971A ES2070089B1 ES 2070089 B1 ES2070089 B1 ES 2070089B1 ES 09301971 A ES09301971 A ES 09301971A ES 9301971 A ES9301971 A ES 9301971A ES 2070089 B1 ES2070089 B1 ES 2070089B1
- Authority
- ES
- Spain
- Prior art keywords
- liter
- mmoles
- organs
- solution
- reduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000000056 organ Anatomy 0.000 title abstract 3
- 230000010412 perfusion Effects 0.000 title abstract 2
- 230000010410 reperfusion Effects 0.000 title abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 3
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- XNPKNHHFCKSMRV-UHFFFAOYSA-N 4-(cyclohexylamino)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCNC1CCCCC1 XNPKNHHFCKSMRV-UHFFFAOYSA-N 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 229940099584 lactobionate Drugs 0.000 abstract 1
- JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Physiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
SOLUCION DE PERFUSION, CONSERVACION Y REPERFUSION DE ORGANOS. PRESENTA SENSIBLEMENTE LA COMPOSICION SIGUIENTE: KBS+SC, 15 Q 5% MMOLES/LITRO; NABS+SC, 100 Q 10% MMOLES/LITRO; MGBS++SC, 13 Q 5% MMOLES/LITRO; CABS++SC, 0,25 Q 5% MMOL ES/LITRO; CLORUROS: CLORURO DE CALCIO 2H SI2SCO, 0,037 G/L, Q 5% MMOLES/LITRO ; CLORURO DE POTASIO, 1,118 G/L, Q 5% MMOLES/LITRO; CLORURO DE MAGNESIO, 2,642 G/L, Q 5% MMOLES/LITRO; HISTIDINA (BASE), 4,650 G/L, 30 Q 10% MMOLES/LITRO; MANITOL, 10,930 G/L, 60 Q 5% MMOLES/LITRO; LACTOBIONATO (ACIDO), 28,664, 80 Q 5% MMOLES/LITRO; GLUTAMATO (ACIDO), 2,942, 20 Q 10% MMOLES/LITRO; AGUA (CANTIDAD PARA UN LITRO REAJUSTADO A PH, 7,30 Q 0,10% MMOLES/LITRO A 0''C); OSMOLALIDAD TEORICA 360 M OSM/KG.; GLUTATION REDUCIDO (GSH) O EQUIVALENTE 0,5 A 10 MMOLES/1 (PREFERENTEMENTE 3), ESTANDO EL GLUTATION REDUCIDO, O EQUIVALENTE, EN SOLUCION BAJO PRESION PARCIAL DE OXIGENO REDUCIDA O NULA Y MANTENIENDOSE SENSIBLEMENTE A ESTE VALOR HASTA LA UTILIZACION. LA INVENCION ES UTIL EN CIRUGIA Y TRASPLANTES DE CORAZON Y OTROS ORGANOS.SOLUTION OF PERFUSION, CONSERVATION AND REPERFUSION OF ORGANS. SENSITIVELY PRESENTS THE FOLLOWING COMPOSITION: KBS + SC, 15 Q 5% MMOLES / LITER; NABS + SC, 100 Q 10% MMOLES / LITER; MGBS ++ SC, 13 Q 5% MMOLES / LITER; CABS ++ SC, 0.25 Q 5% MMOL ES / LITER; CHLORIDES: CALCIUM CHLORIDE 2H SI2SCO, 0.037 G / L, Q 5% MMOLES / LITER; POTASSIUM CHLORIDE, 1,118 G / L, Q 5% MMOLES / LITER; MAGNESIUM CHLORIDE, 2,642 G / L, Q 5% MMOLES / LITER; HISTIDINE (BASE), 4,650 G / L, 30 Q 10% MMOLES / LITER; MANITOL, 10,930 G / L, 60 Q 5% MMOLES / LITER; LACTOBIONATE (ACID), 28,664, 80 Q 5% MMOLES / LITER; GLUTAMATE (ACID), 2,942, 20 Q 10% MMOLES / LITER; WATER (QUANTITY FOR A LITER ADJUSTED TO PH, 7.30 Q 0.10% MMOLES / LITER AT 0``C); THEORETICAL OSMOLALITY 360 M OSM / KG .; REDUCED GLUTATION (GSH) OR EQUIVALENT 0.5 TO 10 MMOLES / 1 (PREFERREDLY 3), THE GLUTATION REDUCED, OR EQUIVALENT, BEING IN SOLUTION UNDER PARTIAL PRESSURE OF OXYGEN REDUCED OR NULL AND KEEPING SENSITIVELY AT THIS UTILITY VALUE. THE INVENTION IS USEFUL IN SURGERY AND HEART TRANSPLANTS AND OTHER ORGANS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94607392A | 1992-09-18 | 1992-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2070089A1 ES2070089A1 (en) | 1995-05-16 |
| ES2070089B1 true ES2070089B1 (en) | 1995-12-16 |
Family
ID=25483919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09301971A Expired - Fee Related ES2070089B1 (en) | 1992-09-18 | 1993-09-17 | SOLUTION OF PERFUSION, CONSERVATION AND REPERFUSION OF ORGANS. |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT407216B (en) |
| BE (1) | BE1007500A3 (en) |
| CA (1) | CA2106249C (en) |
| CH (1) | CH686870A5 (en) |
| DE (1) | DE4331711C2 (en) |
| ES (1) | ES2070089B1 (en) |
| FR (1) | FR2695827B1 (en) |
| GB (1) | GB2270614B (en) |
| IT (1) | IT1272638B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19527734A1 (en) * | 1995-07-28 | 1997-01-30 | Hubert Verhaag | Method and device for preserving tissues and organs, in particular transplant tissues and organs |
| SE9601396D0 (en) * | 1996-04-12 | 1996-04-12 | Dieter Haeussinger | New therapeutic treatment 2 |
| US5880098A (en) * | 1996-04-12 | 1999-03-09 | Pharmacia & Upjohn Aktiebolag | Therapeutic treatment |
| DE19706111C2 (en) * | 1997-02-17 | 1999-02-18 | Fresenius Medical Care De Gmbh | Solution for storage of organs |
| US5834178C1 (en) * | 1997-07-09 | 2002-04-23 | Univ Wayne State | Flush-storage solution for donor organs |
| CN1057192C (en) * | 1997-09-10 | 2000-10-11 | 上海长征医院 | Method for preparing preservation liquid for various kinds of living organs and the prepns. thereof |
| DE19834087C1 (en) * | 1998-07-29 | 2000-03-30 | Mirzaie Sedaposhteh Massoud | Aqueous preservative solution for storage of animal tissue, especially porcine heart valves, contains sodium, potassium, magnesium and calcium salts, glucose and chelate former |
| FR2785501B1 (en) | 1998-11-10 | 2001-01-05 | Centre Nat Rech Scient | PERFUSION AND / OR PRESERVATION AND / OR REPERFUSION SOLUTION DURING ORGAN TRANSPLANTATION |
| GB0028414D0 (en) | 2000-11-22 | 2001-01-03 | Univ Leeds | Flush preservation solution |
| US20060078872A1 (en) * | 2004-10-12 | 2006-04-13 | Atsushi Taguchi | Cell-preservation liquid |
| WO2007128866A2 (en) * | 2006-05-09 | 2007-11-15 | Novobion Oy | Novel chemical compositions |
| WO2014176224A1 (en) * | 2013-04-24 | 2014-10-30 | Somahlution, Llc | Organ and tissue preservation solutions having increased oxygen-content, stability and shelf life |
| CA2910190A1 (en) * | 2013-04-29 | 2014-11-06 | Somahlution, Llc | Formulations containing poly (0-2-hydroxyethyl) starch for increasing the oxygen-content, stability and shelf life of an organ and tissue preservation solution |
| EA201691066A1 (en) | 2013-11-22 | 2016-09-30 | СОМАЛЮШН, ЭлЭлСи | SOLUTIONS TO IMPROVE STABILITY AND LIFE OF SOLUTION FOR CONSERVING BODIES AND FABRICS |
| CN115720893B (en) * | 2022-08-08 | 2024-02-23 | 四川大学华西医院 | Parathyroid gland external preservation solution and preservation method |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| ES2007994A6 (en) * | 1988-08-16 | 1989-07-01 | Grino Boira Jose Maria | Liquid medium for infusion and preservation of organs. |
| US4920044A (en) * | 1988-11-08 | 1990-04-24 | The Cleveland Clinic Foundation | Intracellular flush solution for preserving organs |
| US4938961A (en) * | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
| US5104787A (en) * | 1990-03-05 | 1992-04-14 | Lindstrom Richard L | Method for apparatus for a defined serumfree medical solution useful for corneal preservation |
| US5145771A (en) * | 1990-04-12 | 1992-09-08 | The University Of North Carolina At Chapel Hill | Rinse solution for organs and tissues |
| GB9021325D0 (en) * | 1990-10-01 | 1990-11-14 | Geistlich Soehne Ag | Chemical composition |
| CH683485A5 (en) * | 1990-11-20 | 1994-03-31 | Pasteur Merieux Serums Vacc | infusion solutions, preservation and organ perfusion. |
-
1993
- 1993-09-14 FR FR9310926A patent/FR2695827B1/en not_active Expired - Lifetime
- 1993-09-14 CH CH02760/93A patent/CH686870A5/en not_active IP Right Cessation
- 1993-09-14 BE BE9300965A patent/BE1007500A3/en not_active IP Right Cessation
- 1993-09-15 CA CA002106249A patent/CA2106249C/en not_active Expired - Lifetime
- 1993-09-16 IT ITMI931994A patent/IT1272638B/en active IP Right Grant
- 1993-09-17 ES ES09301971A patent/ES2070089B1/en not_active Expired - Fee Related
- 1993-09-17 DE DE4331711A patent/DE4331711C2/en not_active Expired - Lifetime
- 1993-09-17 GB GB9319264A patent/GB2270614B/en not_active Expired - Lifetime
- 1993-09-20 AT AT0189793A patent/AT407216B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2070089A1 (en) | 1995-05-16 |
| ITMI931994A1 (en) | 1995-03-16 |
| CA2106249C (en) | 2009-04-14 |
| BE1007500A3 (en) | 1995-07-18 |
| CA2106249A1 (en) | 1994-03-19 |
| CH686870A5 (en) | 1996-07-31 |
| DE4331711C2 (en) | 2001-05-03 |
| AT407216B (en) | 2001-01-25 |
| ITMI931994A0 (en) | 1993-09-16 |
| GB9319264D0 (en) | 1993-11-03 |
| FR2695827B1 (en) | 1995-07-28 |
| DE4331711A1 (en) | 1994-03-24 |
| ATA189793A (en) | 2000-06-15 |
| GB2270614B (en) | 1996-03-20 |
| IT1272638B (en) | 1997-06-26 |
| FR2695827A1 (en) | 1994-03-25 |
| GB2270614A (en) | 1994-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20141120 |