ES2070076B1 - METHOD TO INCREASE THE STABILITY OF NANOCAPSULES DURING STORAGE. - Google Patents

METHOD TO INCREASE THE STABILITY OF NANOCAPSULES DURING STORAGE.

Info

Publication number
ES2070076B1
ES2070076B1 ES09300827A ES9300827A ES2070076B1 ES 2070076 B1 ES2070076 B1 ES 2070076B1 ES 09300827 A ES09300827 A ES 09300827A ES 9300827 A ES9300827 A ES 9300827A ES 2070076 B1 ES2070076 B1 ES 2070076B1
Authority
ES
Spain
Prior art keywords
nanocapsules
stability
increase
during storage
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09300827A
Other languages
Spanish (es)
Other versions
ES2070076A1 (en
Inventor
Perdiguer Nuria Carreras
Dachs Anna Coll
Valdivia Francisco J Galan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Cusi SA
Original Assignee
Laboratorios Cusi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09300827A priority Critical patent/ES2070076B1/en
Application filed by Laboratorios Cusi SA filed Critical Laboratorios Cusi SA
Priority to EP94200884A priority patent/EP0621073B1/en
Priority to DK94200884.8T priority patent/DK0621073T3/en
Priority to AT94200884T priority patent/ATE159186T1/en
Priority to DE69406178T priority patent/DE69406178T2/en
Priority to JP6080194A priority patent/JPH0815550B2/en
Publication of ES2070076A1 publication Critical patent/ES2070076A1/en
Application granted granted Critical
Publication of ES2070076B1 publication Critical patent/ES2070076B1/en
Priority to US08/900,036 priority patent/US5885491A/en
Priority to GR980400061T priority patent/GR3025888T3/en
Priority to HK98113203A priority patent/HK1011943A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/203—Exchange of core-forming material by diffusion through the capsule wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/715—On an organic substrate
    • Y10S977/717—Lipid substrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

It comprises: adding a cryoprotective agent into an aqueous dispersion of the cited nanocapsules maintaining gentle stirring until the same dissolves totally. Afterwards, the dispersion thus obtained is subjected to freezing at a temperature no lower than -40o C for about 2 to 4 hours, and, finally, eliminating the water by heating it progressively to a temperature of about 35o C and at reduced pressure, whereby a stable lyophilized product is obtained. It can be conveniently reconstituted by adding water or a more complex aqueous solution to it. Nanocapsules are used in medicine, pharmacy, cosmetics, chemical industry, agriculture, veterinary science, etc.
ES09300827A 1993-04-20 1993-04-20 METHOD TO INCREASE THE STABILITY OF NANOCAPSULES DURING STORAGE. Expired - Fee Related ES2070076B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES09300827A ES2070076B1 (en) 1993-04-20 1993-04-20 METHOD TO INCREASE THE STABILITY OF NANOCAPSULES DURING STORAGE.
DK94200884.8T DK0621073T3 (en) 1993-04-20 1994-03-30 Process for increasing the stability of nanocapsules during storage thereof
AT94200884T ATE159186T1 (en) 1993-04-20 1994-03-30 METHOD FOR INCREASE THE STABILITY OF NANOCAPSULES DURING THEIR STORAGE
DE69406178T DE69406178T2 (en) 1993-04-20 1994-03-30 Process for increasing the stability of nanocapsules during storage
EP94200884A EP0621073B1 (en) 1993-04-20 1994-03-30 Method to increase the stability of nanocapsules during storage thereof
JP6080194A JPH0815550B2 (en) 1993-04-20 1994-04-19 Method for improving storage stability of nanocapsules
US08/900,036 US5885491A (en) 1993-04-20 1997-07-24 Method to increase the stability of nanocapsules during storage thereof
GR980400061T GR3025888T3 (en) 1993-04-20 1998-01-14 Method to increase the stability of nanocapsules during storage thereof.
HK98113203A HK1011943A1 (en) 1993-04-20 1998-12-11 Method to increase the stability of nanocapsules during storage thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09300827A ES2070076B1 (en) 1993-04-20 1993-04-20 METHOD TO INCREASE THE STABILITY OF NANOCAPSULES DURING STORAGE.

Publications (2)

Publication Number Publication Date
ES2070076A1 ES2070076A1 (en) 1995-05-16
ES2070076B1 true ES2070076B1 (en) 1996-04-16

Family

ID=8281529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09300827A Expired - Fee Related ES2070076B1 (en) 1993-04-20 1993-04-20 METHOD TO INCREASE THE STABILITY OF NANOCAPSULES DURING STORAGE.

Country Status (9)

Country Link
US (1) US5885491A (en)
EP (1) EP0621073B1 (en)
JP (1) JPH0815550B2 (en)
AT (1) ATE159186T1 (en)
DE (1) DE69406178T2 (en)
DK (1) DK0621073T3 (en)
ES (1) ES2070076B1 (en)
GR (1) GR3025888T3 (en)
HK (1) HK1011943A1 (en)

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DE10008305A1 (en) * 2000-02-23 2001-09-06 Henkel Kgaa Micro- and nano-capsules with cationic charges on surface are used in laundry and other detergents, skin cleansers, shampoos and skin and hair cosmetics
FR2805761B1 (en) * 2000-03-02 2002-08-30 Mainelab LIPID NANOCAPSULES, METHOD OF PREPARATION AND USE AS A MEDICAMENT
US20060286064A1 (en) * 2000-08-30 2006-12-21 Medivas, Llc Therapeutic polymers and methods
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
BR0212833A (en) * 2001-09-26 2004-10-13 Baxter Int Preparation of submicron sized nanoparticles by dispersion and solvent or liquid phase removal
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
WO2005002546A1 (en) * 2003-06-27 2005-01-13 Smithkline Beecham Corporation Stabilized topotecan liposomal composition and methods
EP1933881B1 (en) * 2005-09-22 2019-03-13 Medivas, LLC Solid polymer delivery compositions and methods for use thereof
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
JP2009524584A (en) * 2005-12-07 2009-07-02 メディバス エルエルシー Method for building a polymer-biologic delivery composition
JP5445130B2 (en) * 2006-05-02 2014-03-19 メディバス エルエルシー Delivery of ophthalmic drugs to the exterior or interior of the eye
US20070282011A1 (en) * 2006-05-09 2007-12-06 Medivas, Llc Biodegradable water soluble polymers
US20090202620A1 (en) * 2006-09-05 2009-08-13 Medivas, Llc Polymer-stabilized liposomal compositions and methods of use
EP2178944A1 (en) * 2007-07-24 2010-04-28 Medivas, LLC Biodegradable cationic polymer gene transfer compositions and methods of use
WO2010019716A1 (en) * 2008-08-13 2010-02-18 Medivas, Llc Aabb-poly(depsipeptide) biodegradable polymers and methods of use
JP2011241147A (en) * 2008-08-29 2011-12-01 Nano Egg:Kk Nanocapsules containing indomethacin and manufacturing method therefor
US8660810B2 (en) 2011-04-19 2014-02-25 Schneider Electric It Corporation System and method to calculate RMS current and true power in a multidrop sensor network
US8666685B2 (en) 2011-04-19 2014-03-04 Schneider Electronic IT Corporation System of intelligent sensors in an electrical panelboard
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
EP3159368A1 (en) 2011-06-23 2017-04-26 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
US10434071B2 (en) 2014-12-18 2019-10-08 Dsm Ip Assets, B.V. Drug delivery system for delivery of acid sensitivity drugs
TWI745358B (en) * 2016-03-10 2021-11-11 日商大日本住友製藥股份有限公司 Composition comprising fine particle and process thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2416008A1 (en) * 1978-02-02 1979-08-31 Oreal LIPOSOME LYOPHILISATES
JPS57147430A (en) * 1981-03-06 1982-09-11 Kureha Chem Ind Co Ltd Preparation of microcapsule
FR2515960A1 (en) * 1981-11-06 1983-05-13 Alkhouri Fallouh Nazir Biodegradable nano:capsules contg. biologically active cpd. - having envelope of polymerised alkyl cyanoacrylate
JPS60100516A (en) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
DE3678308D1 (en) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd METHOD FOR PRODUCING MICROCAPSULES.
CA1285491C (en) * 1985-09-12 1991-07-02 Robert J. Smith Method of treating catabolic dysfunction
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
FR2608942B1 (en) * 1986-12-31 1991-01-11 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOCAPSULES
US5093198A (en) * 1987-06-19 1992-03-03 Temple University Adjuvant-enhanced sustained release composition and method for making
JP3226300B2 (en) * 1990-07-18 2001-11-05 エーザイ株式会社 Pro-nanosphere and method for producing the same
KR930006431B1 (en) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 Microcapsulation of drugs
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
FR2692168B1 (en) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Preparation and use of new dispersible colloidal systems based on cyclodextrin, in the form of nanospheres.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles

Also Published As

Publication number Publication date
EP0621073A1 (en) 1994-10-26
HK1011943A1 (en) 1999-07-23
US5885491A (en) 1999-03-23
ES2070076A1 (en) 1995-05-16
JPH06343854A (en) 1994-12-20
JPH0815550B2 (en) 1996-02-21
EP0621073B1 (en) 1997-10-15
DK0621073T3 (en) 1998-06-02
DE69406178T2 (en) 1998-06-04
GR3025888T3 (en) 1998-04-30
DE69406178D1 (en) 1997-11-20
ATE159186T1 (en) 1997-11-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20101018