ES2062161T3 - Forma liquida estable de acido 5-aminosalicilico. - Google Patents
Forma liquida estable de acido 5-aminosalicilico.Info
- Publication number
- ES2062161T3 ES2062161T3 ES90109011T ES90109011T ES2062161T3 ES 2062161 T3 ES2062161 T3 ES 2062161T3 ES 90109011 T ES90109011 T ES 90109011T ES 90109011 T ES90109011 T ES 90109011T ES 2062161 T3 ES2062161 T3 ES 2062161T3
- Authority
- ES
- Spain
- Prior art keywords
- alkali
- aminosalicylic acid
- asa
- solution
- alkaline earth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Abstract
SE DESCUBRE UNA SOLUCION ACUOSA DE ACIDO 5-AMINOSALICILICO (5-ASA) Y UN ALCALI NO TOXICO, UN METAL ALCALI O UNA SAL METALICA DE TIERRA ALCALINA DE ACIDO 5-AMINOSALICILICO CON UN PH DE 3-5. LA BASE DE LAS SOLUCION ESTA FORMADA POR ACIDO 5-AMINOSALICILICO Y SU ALCALI, METAL ALCALI O SAL METALICA DE TIERRA ALCALINA. LAS SOLUCIONES TAMBIEN CONTIENEN UN ANTIOXIDANTE Y UN AGENTE METALICO COMPLEJIZADOR. EN SU PRACTICA PREFERIDA, LA SAL 5-ASA SE FORMA IN SITU POR ADICION DE UN ALCALI, METAL ALACLI O HIDROXIDO METALICO DE TIERRA ALCALINA A UNA SOLUCION DE 5-ASA. LA SOLUCION ES ESTABLE Y NO PRESENTA UNA DECOLORACION SIGNIFICATIVA DEBIDA A LA DESCOMPOSICION DEL 5-ASA EN PERIODOS PROLONGADOS DE TIEMPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/352,064 US5010069A (en) | 1989-05-15 | 1989-05-15 | Stable liquid form of 5-aminosalicylic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062161T3 true ES2062161T3 (es) | 1994-12-16 |
Family
ID=23383642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90109011T Expired - Lifetime ES2062161T3 (es) | 1989-05-15 | 1990-05-14 | Forma liquida estable de acido 5-aminosalicilico. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5010069A (es) |
EP (1) | EP0398207B1 (es) |
JP (1) | JPH0347161A (es) |
AT (1) | ATE109660T1 (es) |
CA (1) | CA2016825A1 (es) |
DE (1) | DE69011399T2 (es) |
DK (1) | DK0398207T3 (es) |
ES (1) | ES2062161T3 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992016214A1 (en) * | 1991-03-15 | 1992-10-01 | Norwich Eaton Pharmaceuticals Inc. | The use of 5-aminosalicylic acid in the treatment of irritable bowel syndrome - diarrheal phase or type (ibs-d) |
EP0586488B1 (de) * | 1991-06-07 | 1995-05-03 | Byk Gulden Lomberg Chemische Fabrik GmbH | Pharmazeutische klistierzubereitung |
FR2738150B1 (fr) * | 1995-09-01 | 1997-10-31 | Synthelabo | Utilisation de la sulphasalazine et de ses metabolites pour la fabrication d'un medicament utile dans le traitement de l'insuffisance veineuse et des ulceres veineux |
IT1277663B1 (it) * | 1995-09-28 | 1997-11-11 | Crinos Industria Farmaco | Sospensioni acquose stabili di mesalazina per uso topico |
US6326364B1 (en) | 1999-02-08 | 2001-12-04 | Cedars-Sinai Medical Center | Use of 5-aminosalicylates as antimicrobial agents |
WO2002018324A2 (en) * | 2000-08-29 | 2002-03-07 | Nobex Corporation | Immunoregulatory compounds, derivatives thereof and their use |
JP3805646B2 (ja) * | 2001-05-25 | 2006-08-02 | 久光メディカル株式会社 | 医薬液剤 |
US8048924B2 (en) * | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
US20040087527A1 (en) * | 2002-10-31 | 2004-05-06 | Day Brian J. | Methods for treatment of thiol-containing compound deficient conditions |
WO2005027932A1 (ja) * | 2003-09-22 | 2005-03-31 | Nisshin Kyorin Pharmaceutical Co., Ltd. | 変色改善された5−アミノサリチル酸固形製剤およびその保存方法 |
US7417037B2 (en) | 2004-01-20 | 2008-08-26 | The Board Of Regents Of The University Of Oklahoma | Compositions and methods of treatment for inflammatory diseases |
WO2006014549A2 (en) * | 2004-07-07 | 2006-02-09 | Nobex Corporation | Synthesis of azo bonded immunoregulatory compounds |
US7645801B2 (en) | 2007-01-29 | 2010-01-12 | Alaven Pharmaceutical Llc | Reduced irritant enema for treatment of inflammatory bowel disease (IBD) |
KR101420315B1 (ko) | 2014-03-19 | 2014-07-17 | 남봉길 | 약학적 액제 조성물 |
US20160263152A1 (en) * | 2015-03-14 | 2016-09-15 | Gavis Pharmaceuticals | Bowel cleansing composition with improved taste |
AR108992A1 (es) * | 2016-07-08 | 2018-10-17 | Ferring Bv | Formulaciones líquidas estabilizadas que contienen picosulfato |
CN113350277A (zh) * | 2021-06-30 | 2021-09-07 | 广东科伦药业有限公司 | 一种治疗化疗口腔黏膜炎的美沙拉秦含漱液及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2647853A (en) * | 1949-11-29 | 1953-08-04 | Lab Francais Chimiotherapie | Injectable solution of salt of para-aminosalicylic acid |
WO1981002671A1 (en) * | 1980-03-20 | 1981-10-01 | Ferring Farma Lab | Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease by oral administration |
DE3151196A1 (de) * | 1981-12-23 | 1983-06-30 | Kurt Heinz Prof. Dr. 7800 Freiburg Bauer | Verfahren zur herstellung von gut loeslichen 5-aminosalicylsaeure-arzneimittelzubereitungen |
US4664256A (en) * | 1983-09-06 | 1987-05-12 | Farmaceutisk Laboratorium Ferring A/S | Packaged stable enema solution or suspension containing 5-aminosalicyclic acid |
US4657900A (en) * | 1983-09-27 | 1987-04-14 | Rowell Laboratories | Pharmaceutical article of manufacture comprising a bisulfite stabilized aqueous solution of 5-aminosalicylic acid and method |
DK536987A (da) * | 1987-10-14 | 1989-04-15 | Ferring Farma Lab | Anvendelse af 5-aminosalicylsyre (5-asa) til fremstilling af et farmaceutisk praeparat til anvendelse ved reperfusionsbehandling |
-
1989
- 1989-05-15 US US07/352,064 patent/US5010069A/en not_active Expired - Fee Related
-
1990
- 1990-05-14 ES ES90109011T patent/ES2062161T3/es not_active Expired - Lifetime
- 1990-05-14 DE DE69011399T patent/DE69011399T2/de not_active Expired - Fee Related
- 1990-05-14 EP EP90109011A patent/EP0398207B1/en not_active Expired - Lifetime
- 1990-05-14 AT AT90109011T patent/ATE109660T1/de not_active IP Right Cessation
- 1990-05-14 JP JP2121424A patent/JPH0347161A/ja active Pending
- 1990-05-14 DK DK90109011.8T patent/DK0398207T3/da active
- 1990-05-15 CA CA002016825A patent/CA2016825A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPH0347161A (ja) | 1991-02-28 |
DE69011399D1 (de) | 1994-09-15 |
CA2016825A1 (en) | 1990-11-15 |
DE69011399T2 (de) | 1994-12-15 |
ATE109660T1 (de) | 1994-08-15 |
EP0398207B1 (en) | 1994-08-10 |
DK0398207T3 (da) | 1994-10-03 |
EP0398207A1 (en) | 1990-11-22 |
US5010069A (en) | 1991-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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