ES2061403A1 - Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico. - Google Patents
Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico.Info
- Publication number
- ES2061403A1 ES2061403A1 ES09300781A ES9300781A ES2061403A1 ES 2061403 A1 ES2061403 A1 ES 2061403A1 ES 09300781 A ES09300781 A ES 09300781A ES 9300781 A ES9300781 A ES 9300781A ES 2061403 A1 ES2061403 A1 ES 2061403A1
- Authority
- ES
- Spain
- Prior art keywords
- acetylthio
- aminobutanol
- methylpropionic acid
- acid
- optical resolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UN NUEVO PROCEDIMIENTO DE OBTENCION DEL ACIDO D-(-)-3-ACETILTIO-2-METILPROPIONICO, IMPORTANTE INTERMEDIO PARA LA SINTESIS DEL PRODUCTO ANTIHIPERTENSIVO CAPTOPRIL, CONSISTENTE EN LA RESOLUCION DE LA MEZCLA RACEMICA DEL MENCIONADO ACIDO POR MEDIO DE LA FORMACION DE LA MEZCLA DE LAS SALES DIASTEREOISOMERAS DEL MISMO, EN UN DISOLVENTE APROPIADO, CON LA BASE DE BAJO PESO MOLECULAR L-(+)-2-AMINOBUTANOL, CRISTALIZACION SELECTIVA DE LA SAL DIASTEREOISOMERA DEL ACIDO D-(-)-3-ACETILTIO-2-METILPROPIONICO CON L-(+)-2-AMINOBUTANOL Y LIBERACION DEL ACIDO D-(-)-3-ACETILTIO-2-METILPROPIONICO MEDIANTE DESPLAZAMIENTO DEL MISMO CON UN ACIDO MAS FUERTE.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09300781A ES2061403B1 (es) | 1993-04-16 | 1993-04-16 | Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico. |
US08/138,693 US5367091A (en) | 1993-04-16 | 1993-10-19 | Optical resolution of DL-3-acetylthio-2-methylpropionic acid using L-(+)-2-aminobutanol as resolving agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09300781A ES2061403B1 (es) | 1993-04-16 | 1993-04-16 | Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2061403A1 true ES2061403A1 (es) | 1994-12-01 |
ES2061403B1 ES2061403B1 (es) | 1995-06-16 |
Family
ID=8281466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09300781A Expired - Fee Related ES2061403B1 (es) | 1993-04-16 | 1993-04-16 | Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico. |
Country Status (2)
Country | Link |
---|---|
US (1) | US5367091A (es) |
ES (1) | ES2061403B1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE319668T1 (de) * | 2003-04-09 | 2006-03-15 | Servier Lab | Verfahren zur synthese von (2s)-indolin-2- carbonsäure, und verwendung in der synthese von perindopril |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0008833A1 (en) * | 1978-09-07 | 1980-03-19 | Océ-Andeno B.V. | Optically active derivatives of mercaptoisobutyric acid and a process for preparing them |
US4224457A (en) * | 1978-05-18 | 1980-09-23 | Santen Pharmaceutical Co., Ltd. | Process for manufacturing optically active sulfur-containing carboxylic acid |
US4325886A (en) * | 1979-12-07 | 1982-04-20 | Sumitomo Chemical Company, Limited | Optical resolution of acylthiopropionic acid |
WO1990008126A1 (en) * | 1989-01-16 | 1990-07-26 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Resolution process |
EP0423467A2 (en) * | 1989-10-17 | 1991-04-24 | Nissan Chemical Industries Ltd. | Method for optical resolution of (+/-)-2-(3-benzoyl)-phenylpropionic acid |
EP0468592A2 (en) * | 1990-07-27 | 1992-01-29 | Westspur Investments Limited | Process for the preparation of S(+)-6-methoxy-alpha-methyl-2-naphtalene-acetic acid |
US5097043A (en) * | 1988-01-15 | 1992-03-17 | E. R. Squibb & Sons, Inc. | Process of preparing captopril |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
JPS567756A (en) * | 1979-06-28 | 1981-01-27 | Sumitomo Chem Co Ltd | Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative |
US4294775A (en) * | 1980-03-03 | 1981-10-13 | Ethyl Corporation | Resolution of acylated D,L-alkyl substituted alkanoic acids |
NL8001341A (nl) * | 1980-03-06 | 1981-10-01 | Oce Andeno Bv | Werkwijze voor de splitsing van dl-s-benzoyl-beta-mercapto-isoboterzuur alsmede produkten verkregen onder toepassing van deze werkwijze. |
US4559178A (en) * | 1980-10-06 | 1985-12-17 | American Home Products Corporation | Resolution of 3-benzoylthio-2-methyl-propanoic acid with (+)-dehydroabietylamine |
US4536601A (en) * | 1982-09-28 | 1985-08-20 | Dainippon Pharmaceutical Co., Ltd. | Optically active N-substituted phenylalaninols and use thereof |
US5001251A (en) * | 1988-01-15 | 1991-03-19 | E. R. Squibb & Sons, Inc. | Optical resolution of DL-3-acylthio-2-methylpropanoic acid |
-
1993
- 1993-04-16 ES ES09300781A patent/ES2061403B1/es not_active Expired - Fee Related
- 1993-10-19 US US08/138,693 patent/US5367091A/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4224457A (en) * | 1978-05-18 | 1980-09-23 | Santen Pharmaceutical Co., Ltd. | Process for manufacturing optically active sulfur-containing carboxylic acid |
EP0008833A1 (en) * | 1978-09-07 | 1980-03-19 | Océ-Andeno B.V. | Optically active derivatives of mercaptoisobutyric acid and a process for preparing them |
US4325886A (en) * | 1979-12-07 | 1982-04-20 | Sumitomo Chemical Company, Limited | Optical resolution of acylthiopropionic acid |
US5097043A (en) * | 1988-01-15 | 1992-03-17 | E. R. Squibb & Sons, Inc. | Process of preparing captopril |
WO1990008126A1 (en) * | 1989-01-16 | 1990-07-26 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Resolution process |
EP0423467A2 (en) * | 1989-10-17 | 1991-04-24 | Nissan Chemical Industries Ltd. | Method for optical resolution of (+/-)-2-(3-benzoyl)-phenylpropionic acid |
EP0468592A2 (en) * | 1990-07-27 | 1992-01-29 | Westspur Investments Limited | Process for the preparation of S(+)-6-methoxy-alpha-methyl-2-naphtalene-acetic acid |
Also Published As
Publication number | Publication date |
---|---|
US5367091A (en) | 1994-11-22 |
ES2061403B1 (es) | 1995-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20070417 |