ES2059453T3 - Un procedimiento para la produccion de interleuquina 4 humana. - Google Patents
Un procedimiento para la produccion de interleuquina 4 humana.Info
- Publication number
- ES2059453T3 ES2059453T3 ES88112458T ES88112458T ES2059453T3 ES 2059453 T3 ES2059453 T3 ES 2059453T3 ES 88112458 T ES88112458 T ES 88112458T ES 88112458 T ES88112458 T ES 88112458T ES 2059453 T3 ES2059453 T3 ES 2059453T3
- Authority
- ES
- Spain
- Prior art keywords
- human
- human interleukin
- dna sequence
- located below
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B75/00—Other engines
- F02B75/02—Engines characterised by their cycles, e.g. six-stroke
- F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
- F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UNA NUEVA INTERLEUCINA 4 (IL4) HUMANA CON EFECTOS INMUNOACTIVANTES QUE SE CARACTERIZA POR (A) UN PESO MOLECULAR TOTAL DE 17000 A 19000, (B) UN PESO MULECULAR DE LA CADENA DE AZUCAR DE 2000 A 4000; Y TAMBIEN DESCRIBE NUEVOS VECTORES DE EXPRESION PARA LA IL4 HUMANA, QUE COMPRENDEN: (1) UNA SECUENCIA DE DNA CODIFICANDO LA INTERLEUCINA 4 HUMANA SITUADA POR DEBAJO DE UN PROMOTOR INICIAL DE SV40, Y (2) UNA SECUENCIA DE DNA CODIFICADORA DE LA DIHIDROFALATO REDUCTORA SITUADA POR DEBAJO DE UN PROMOTOR QUE ACTUA EN CELULAS EUCARIANTES, ADEMAS DESCRIBE LOS TRANSFORMANTES OBTENIDOS POR MEDIO DE LA INYECCION DE EL VECTOR DE EXPRESION DE LA IL4 HUMANA EN CELULAS DE OVARIO DE HAMSTER CHINO DIHIDROFOLATO - REDUCTORA DEFECTIVAS. LA IL4 HUMANA ES UTIL PARA EL TRATAMIENTO Y PREVENCION DE CANCER, INFECCIONES, SIDA, DEFICIENCIAS INMUNOLOGICAS FUNCIONALES, ETC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19266687 | 1987-08-03 | ||
JP3948288 | 1988-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2059453T3 true ES2059453T3 (es) | 1994-11-16 |
Family
ID=26378886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88112458T Expired - Lifetime ES2059453T3 (es) | 1987-08-03 | 1988-08-01 | Un procedimiento para la produccion de interleuquina 4 humana. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0302429B1 (es) |
KR (1) | KR890003804A (es) |
DE (1) | DE3882611T2 (es) |
ES (1) | ES2059453T3 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2218420B (en) * | 1988-04-12 | 1992-07-15 | British Bio Technology | Synthetic gene encoding interleukin 4 |
HUT63062A (en) * | 1990-03-21 | 1993-07-28 | Schering Corp | Process for producing pharmaceutical compositions increasing the immune response and comprising il-4 |
US5827670A (en) * | 1990-08-02 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Methods of isolating and detecting bone marrow stromal cells with VCAM-1-specific antibodies |
US7449186B1 (en) | 1990-08-02 | 2008-11-11 | Fred Hutchinson Cancer Research Center | Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies |
US5206345A (en) * | 1990-08-02 | 1993-04-27 | Fred Hutchinson Cancer Research Center | Il-4 and tnf induce mab 6g10-recognized expression on bone marrow stromal cells |
HU215389B (hu) * | 1990-09-06 | 1998-12-28 | Schering Corp. | Eljárás hatóanyagként IL-4-et tartalmazó tömött tumorok kezelésére alkalmas gyógyszerkészítmények előállítására |
DE69209051T2 (de) * | 1991-01-10 | 1996-08-08 | Schering Corp | Verwendung von il-4 zur verstärkung von wundheilung und besserung und zur heilung von infizierten wunden und wunden bei diabetischen säugetieren |
US5494662A (en) * | 1992-04-27 | 1996-02-27 | Ono Pharmaceutical Co., Ltd. | Stimulator for bone formation |
US7361331B2 (en) | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
CA2356937A1 (en) | 1998-12-31 | 2000-07-13 | Richard J. Whitley | Recombinant herpes simplex virus useful for treating neoplastic disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT83761B (pt) * | 1985-11-19 | 1989-06-30 | Schering Biotech Corp | Metodo para a producao de interleuquina-4 de mamifero |
ZA872781B (en) * | 1986-05-19 | 1987-10-05 | Immunology Ventures | B-cell stimulating factor |
-
1988
- 1988-08-01 DE DE88112458T patent/DE3882611T2/de not_active Expired - Fee Related
- 1988-08-01 ES ES88112458T patent/ES2059453T3/es not_active Expired - Lifetime
- 1988-08-01 EP EP88112458A patent/EP0302429B1/en not_active Expired - Lifetime
- 1988-08-03 KR KR1019880009880A patent/KR890003804A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0302429A1 (en) | 1989-02-08 |
DE3882611D1 (de) | 1993-09-02 |
EP0302429B1 (en) | 1993-07-28 |
KR890003804A (ko) | 1989-04-18 |
DE3882611T2 (de) | 1993-12-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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