ES2059361T3 - Complejo de proteinas recombinantes que tiene actividad de factor viii:c su produccion y uso. - Google Patents
Complejo de proteinas recombinantes que tiene actividad de factor viii:c su produccion y uso.Info
- Publication number
- ES2059361T3 ES2059361T3 ES87300695T ES87300695T ES2059361T3 ES 2059361 T3 ES2059361 T3 ES 2059361T3 ES 87300695 T ES87300695 T ES 87300695T ES 87300695 T ES87300695 T ES 87300695T ES 2059361 T3 ES2059361 T3 ES 2059361T3
- Authority
- ES
- Spain
- Prior art keywords
- factor viii
- activity
- protein complex
- production
- recombinant protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
COMPOSICIONES QUE TIENEN ACTIVIDAD DE FACTOR VIII: C Y REACTIVOS EN CRUZ INMUNOLOGICAMENTE CON FACTOR VIII: C SON PREPARADOS POR LA EXPRESION DE GENES CODIFICADOS PARA EL TERMINO N Y TERMINO C DEL GEN CON FACTOR VIII: C, DONDE CADA UNA DE LAS SECUENCIAS TIENE UNA SECUENCIA DE SEÑAL INDEPENDIENTE. LOS GENES ESTRUCTURALES PARA LOS TERMINOS N- Y C- PUEDEN ESTAR EN LA MISMA ESTRUCTURA DE ADN O EN DISTINTA, CADA UNO TIENE SEÑALES REGULATORIAS DE TRASLACION Y TRANSCRIPCION INDEPENDIENTES. LA/S CONSTRUCCION/ES SE INTRODUCE/N EN LAS CELULAS DE MAMIFEROS DONDE SE PRODUCE UN COMPLEJO PROTEINICO ACTIVO QUE TIENE FACTOR VIII: ACTIVIDAD C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82298986A | 1986-01-27 | 1986-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2059361T3 true ES2059361T3 (es) | 1994-11-16 |
Family
ID=25237495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87300695T Expired - Lifetime ES2059361T3 (es) | 1986-01-27 | 1987-01-27 | Complejo de proteinas recombinantes que tiene actividad de factor viii:c su produccion y uso. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0232112B1 (es) |
JP (3) | JPH0797996B2 (es) |
AT (1) | ATE97956T1 (es) |
AU (1) | AU610059B2 (es) |
DE (1) | DE3788289T2 (es) |
DK (1) | DK175407B1 (es) |
ES (1) | ES2059361T3 (es) |
FI (1) | FI98829C (es) |
NO (1) | NO179106C (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7138505B1 (en) | 1984-01-12 | 2006-11-21 | Novartis Vaccines And Diagnostics, Inc. | Factor VIII:C nucleic acid molecules |
KR910006424B1 (ko) * | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
US5198349A (en) * | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
US5595886A (en) | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US5422260A (en) * | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
FR2613379B2 (fr) * | 1987-04-03 | 1990-04-06 | Transgene Sa | Procede de preparation de fragments du facteur viii a partir de cellules de mammiferes |
EP0251843A1 (fr) * | 1986-06-06 | 1988-01-07 | Transgene S.A. | Procédé de préparation de facteur VIII à partir de cellules de mammifères |
NO872932L (no) * | 1986-07-18 | 1988-01-19 | Gist Brocades Nv | Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika. |
US6060447A (en) * | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US6346513B1 (en) | 1987-06-12 | 2002-02-12 | Baxter Trading Gmbh | Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
AU627150B2 (en) * | 1987-06-12 | 1992-08-20 | Immuno Ag | Novel proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
IL86693A (en) * | 1987-06-12 | 1994-06-24 | Stichting Centraal Lab | Proteins that have the activity IIIV of the blood, a process for their preparation that uses cells are produced through genetic engineering and pharmaceutical preparations that contain them |
EP0690126B1 (en) * | 1987-06-12 | 2001-11-28 | Baxter Aktiengesellschaft | Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
JPH0387173A (ja) * | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
DK0500734T3 (da) * | 1989-11-17 | 1998-03-30 | Chiron Corp | Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf |
FR2657884B1 (fr) | 1990-02-05 | 1994-09-02 | Tm Innovation | Procede pour la preparation du facteur viii humain et d'analogues du facteur viii. |
US5610033A (en) * | 1990-04-25 | 1997-03-11 | Novo Nordisk A/S | Method of producing proteins with FVIII activity and/or FVIII derivatives |
CA2078721A1 (en) * | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
DK53792D0 (da) * | 1992-04-24 | 1992-04-24 | Novo Nordisk As | Fremgangsmaade til fremstilling af proteiner |
US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
EP2298926A1 (en) | 2003-09-30 | 2011-03-23 | The Trustees of The University of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
EP3409296A1 (en) | 2005-04-07 | 2018-12-05 | The Trustees of the University of Pennsylvania | Method of increasing the function of an aav vector |
EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
WO2011095604A1 (en) | 2010-02-04 | 2011-08-11 | Octapharma Biopharmaceuticals Gmbh | Half-life prolongation of proteins |
SG10201908848RA (en) | 2010-03-29 | 2019-10-30 | Univ Pennsylvania | Pharmacologically induced transgene ablation system |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
PL2675902T3 (pl) | 2011-02-17 | 2019-08-30 | The Trustees Of The University Of Pennsylvania | Kompozycje i sposoby do zmieniania specyficzności względem tkanki i poprawy transferu genu z udziałem aav9 |
WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
US10058624B2 (en) | 2015-04-16 | 2018-08-28 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
JP6577401B2 (ja) | 2016-03-31 | 2019-09-18 | 本田技研工業株式会社 | ダクトへのレゾネータの取付け構造 |
US20240043494A1 (en) | 2020-08-07 | 2024-02-08 | Amicus Therapeutics, Inc. | Vesicle Targeting Proteins And Uses Of Same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534273B1 (fr) * | 1982-10-07 | 1985-09-13 | Pasteur Institut | Lignees cellulaires originaires de mammiferes superieurs, productrices d'hormone de croissance, de preference humaine, et vecteurs pour leur obtention |
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4657894A (en) * | 1983-03-31 | 1987-04-14 | Scripps Clinic & Research Foundation | New factor VIII coagulant polypeptides |
US4840896A (en) * | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
DK165506C (da) * | 1984-01-12 | 1993-04-19 | Chiron Corp | Proteinpraeparat med koagulationsaktivitet samt fremgangsmaade til fremstilling deraf |
SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
EP0218712B1 (en) * | 1985-04-12 | 1992-02-26 | Genetics Institute, Inc. | Novel procoagulant proteins |
NO872932L (no) * | 1986-07-18 | 1988-01-19 | Gist Brocades Nv | Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika. |
-
1987
- 1987-01-21 FI FI870261A patent/FI98829C/fi not_active IP Right Cessation
- 1987-01-27 NO NO870323A patent/NO179106C/no unknown
- 1987-01-27 AU AU68014/87A patent/AU610059B2/en not_active Expired
- 1987-01-27 DE DE3788289T patent/DE3788289T2/de not_active Expired - Lifetime
- 1987-01-27 AT AT87300695T patent/ATE97956T1/de not_active IP Right Cessation
- 1987-01-27 EP EP87300695A patent/EP0232112B1/en not_active Expired - Lifetime
- 1987-01-27 JP JP62018141A patent/JPH0797996B2/ja not_active Expired - Fee Related
- 1987-01-27 ES ES87300695T patent/ES2059361T3/es not_active Expired - Lifetime
- 1987-01-27 DK DK198700428A patent/DK175407B1/da not_active IP Right Cessation
-
1993
- 1993-04-20 JP JP5093391A patent/JPH0771496B2/ja not_active Expired - Lifetime
-
1995
- 1995-03-06 JP JP7045906A patent/JP2513993B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH06205678A (ja) | 1994-07-26 |
FI870261A (fi) | 1987-07-28 |
EP0232112A2 (en) | 1987-08-12 |
JPH0771496B2 (ja) | 1995-08-02 |
NO179106B (no) | 1996-04-29 |
DK42887A (da) | 1987-07-28 |
AU610059B2 (en) | 1991-05-16 |
FI98829B (fi) | 1997-05-15 |
JP2513993B2 (ja) | 1996-07-10 |
JPS62282594A (ja) | 1987-12-08 |
DE3788289D1 (de) | 1994-01-13 |
EP0232112B1 (en) | 1993-12-01 |
JPH0797996B2 (ja) | 1995-10-25 |
DK175407B1 (da) | 2004-09-27 |
ATE97956T1 (de) | 1993-12-15 |
EP0232112A3 (en) | 1987-12-23 |
FI98829C (fi) | 1997-08-25 |
NO870323L (no) | 1987-07-28 |
AU6801487A (en) | 1987-07-30 |
DK42887D0 (da) | 1987-01-27 |
NO870323D0 (no) | 1987-01-27 |
NO179106C (no) | 1996-08-07 |
FI870261A0 (fi) | 1987-01-21 |
DE3788289T2 (de) | 1994-06-23 |
JPH07278197A (ja) | 1995-10-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2059361T3 (es) | Complejo de proteinas recombinantes que tiene actividad de factor viii:c su produccion y uso. | |
DE69833784D1 (de) | Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren | |
FI101720B1 (fi) | Synteettisen DNA:n konstruointi ja sen käyttö suurten polypeptidien synteesissä | |
NL300137I1 (nl) | Recombinante proteïnen van virussen geassocieerd met het | |
DE68929043T2 (de) | Für androgen-rezeptor-protein kodierende dna | |
PT101297A (pt) | Factores mitogenicos gliais, sua preparacao e utilizacao | |
DE69930955D1 (de) | Polypeptide mit lysophospholipaseaktivität und nukleinesäuren die sie kodieren | |
FI871908A0 (fi) | Transformering av trichoderma-moegel. | |
DE60043428D1 (de) | POLYPEPTIDE MIT VERZWEIGUNGSENZYM-AKTIVITäT UND FüR DIESE KODIERENDE NUKLEINSäUREN | |
ES2144399T3 (es) | Clonado del adn de virus de anemia de los pollos. | |
NO892630L (no) | Interleukin-7. | |
ATE384787T1 (de) | Tripeptidyl-aminopeptidase | |
DE69837475D1 (de) | Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren | |
BR9713450A (pt) | Quimiocinas de mamìfero | |
DE3855634D1 (de) | Innerhalb des alpha-Locus gelegenes T-Zell-Rezeptor-Gen und DNA-Konstruktionen | |
ATE196165T1 (de) | Methoden zur herstellung von protein c | |
ATE277176T1 (de) | Faltende proteine | |
ES2059431T3 (es) | Mutantes de la creatinamidinohidrolasa estables. | |
DE60026049D1 (de) | POLYPEPTIDE MIT GLUCANOTRANSFERASE AKTIVITÄT UND DAFüR KODIERENDE NUKLEINSÄUREN | |
ES2061574T3 (es) | Acil-peptido-hidrolasa y metodos de produccion y uso. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 232112 Country of ref document: ES |