DK42887D0 - Fremgangsmaade til fremstilling af et proteinkompleks med human faktor viii:c aktivitet ved rekombinant-teknik - Google Patents

Fremgangsmaade til fremstilling af et proteinkompleks med human faktor viii:c aktivitet ved rekombinant-teknik

Info

Publication number
DK42887D0
DK42887D0 DK042887A DK42887A DK42887D0 DK 42887 D0 DK42887 D0 DK 42887D0 DK 042887 A DK042887 A DK 042887A DK 42887 A DK42887 A DK 42887A DK 42887 D0 DK42887 D0 DK 42887D0
Authority
DK
Denmark
Prior art keywords
factor viii
protein complex
preparing
procedure
activity
Prior art date
Application number
DK042887A
Other languages
English (en)
Other versions
DK42887A (da
DK175407B1 (da
Inventor
Rae Lyn Burke
Mirella Ezban Rasmussen
Original Assignee
Chiron Corp
Nordisk Gentofte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Nordisk Gentofte filed Critical Chiron Corp
Publication of DK42887D0 publication Critical patent/DK42887D0/da
Publication of DK42887A publication Critical patent/DK42887A/da
Application granted granted Critical
Publication of DK175407B1 publication Critical patent/DK175407B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
DK198700428A 1986-01-27 1987-01-27 Fremgangsmåde til fremstilling af et proteinkompleks med human faktor VIII:C aktivitet ved rekombinant-teknik DK175407B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82298986A 1986-01-27 1986-01-27
US82298986 1986-01-27

Publications (3)

Publication Number Publication Date
DK42887D0 true DK42887D0 (da) 1987-01-27
DK42887A DK42887A (da) 1987-07-28
DK175407B1 DK175407B1 (da) 2004-09-27

Family

ID=25237495

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700428A DK175407B1 (da) 1986-01-27 1987-01-27 Fremgangsmåde til fremstilling af et proteinkompleks med human faktor VIII:C aktivitet ved rekombinant-teknik

Country Status (9)

Country Link
EP (1) EP0232112B1 (da)
JP (3) JPH0797996B2 (da)
AT (1) ATE97956T1 (da)
AU (1) AU610059B2 (da)
DE (1) DE3788289T2 (da)
DK (1) DK175407B1 (da)
ES (1) ES2059361T3 (da)
FI (1) FI98829C (da)
NO (1) NO179106C (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5422260A (en) * 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
EP0251843A1 (fr) * 1986-06-06 1988-01-07 Transgene S.A. Procédé de préparation de facteur VIII à partir de cellules de mammifères
FR2613379B2 (fr) * 1987-04-03 1990-04-06 Transgene Sa Procede de preparation de fragments du facteur viii a partir de cellules de mammiferes
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5171844A (en) 1987-06-12 1992-12-15 Gist-Brocades N.W. Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US6346513B1 (en) 1987-06-12 2002-02-12 Baxter Trading Gmbh Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
AU627150B2 (en) * 1987-06-12 1992-08-20 Immuno Ag Novel proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
EP0690126B1 (en) * 1987-06-12 2001-11-28 Baxter Aktiengesellschaft Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
JP2865861B2 (ja) * 1989-11-17 1999-03-08 ノボ ノルディスク アクティーゼルスカブ 第▲ｖｉｉｉ▼：ｃ因子活性を有するタンパク質複合体およびその製法
FR2657884B1 (fr) 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5610033A (en) * 1990-04-25 1997-03-11 Novo Nordisk A/S Method of producing proteins with FVIII activity and/or FVIII derivatives
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
DK2292779T3 (da) 2003-09-30 2017-02-27 Univ Pennsylvania Adenoassocierede virus (aav)-clader, sekvenser, vektorer indeholdende samme og anvendelser deraf
EP1707634A1 (en) 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
EP4234687A2 (en) 2005-04-07 2023-08-30 The Trustees of the University of Pennsylvania Method of increasing the function of an aav vector
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins
CN102869779A (zh) 2010-03-29 2013-01-09 宾夕法尼亚大学托管会 药理学诱导的转基因消融系统
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
CN103502458B (zh) 2011-02-17 2016-11-16 宾夕法尼亚大学托管会 用于改变组织特异性和改善aav9-介导的基因转移的组合物和方法
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
EP3626274A3 (en) 2015-04-16 2020-06-17 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
JP6577401B2 (ja) 2016-03-31 2019-09-18 本田技研工業株式会社 ダクトへのレゾネータの取付け構造
JP2023537070A (ja) 2020-08-07 2023-08-30 アミカス セラピューティックス インコーポレイテッド 小胞を標的とするタンパク質及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534273B1 (fr) * 1982-10-07 1985-09-13 Pasteur Institut Lignees cellulaires originaires de mammiferes superieurs, productrices d'hormone de croissance, de preference humaine, et vecteurs pour leur obtention
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
DE10399009I1 (de) * 1984-01-12 2003-10-23 Chiron Corp F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
CA1341174C (en) * 1985-04-12 2001-01-30 John J. Toole Jr. Procoagulant proteins derived from factor viii: c
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies

Also Published As

Publication number Publication date
NO179106C (no) 1996-08-07
AU610059B2 (en) 1991-05-16
ATE97956T1 (de) 1993-12-15
JPH07278197A (ja) 1995-10-24
DK42887A (da) 1987-07-28
NO870323D0 (no) 1987-01-27
FI870261A0 (fi) 1987-01-21
EP0232112A3 (en) 1987-12-23
JPH0797996B2 (ja) 1995-10-25
JP2513993B2 (ja) 1996-07-10
NO870323L (no) 1987-07-28
FI870261A (fi) 1987-07-28
JPH0771496B2 (ja) 1995-08-02
AU6801487A (en) 1987-07-30
FI98829C (fi) 1997-08-25
DE3788289T2 (de) 1994-06-23
DE3788289D1 (de) 1994-01-13
FI98829B (fi) 1997-05-15
EP0232112B1 (en) 1993-12-01
DK175407B1 (da) 2004-09-27
EP0232112A2 (en) 1987-08-12
NO179106B (no) 1996-04-29
JPH06205678A (ja) 1994-07-26
JPS62282594A (ja) 1987-12-08
ES2059361T3 (es) 1994-11-16

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Legal Events

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PUP Patent expired