ES2057901T3 - Derivados de benzotiazol, su preparacion y los medicamentos que les contienen. - Google Patents

Derivados de benzotiazol, su preparacion y los medicamentos que les contienen.

Info

Publication number
ES2057901T3
ES2057901T3 ES91910896T ES91910896T ES2057901T3 ES 2057901 T3 ES2057901 T3 ES 2057901T3 ES 91910896 T ES91910896 T ES 91910896T ES 91910896 T ES91910896 T ES 91910896T ES 2057901 T3 ES2057901 T3 ES 2057901T3
Authority
ES
Spain
Prior art keywords
pct
preparation
radical
benzotiazole
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910896T
Other languages
English (en)
Inventor
Claude Gueremy
Patrick Jimonet
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2057901T3 publication Critical patent/ES2057901T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE LA FORMULA (I), EN LA CUAL R1 REPRESENTA UN RADICAL POLIFLUOROALCOXI; R2 REPRESENTA UN ATOMO DE AZUFRE O DE NITROGENO SUSTITUIDO POR UN RADICAL ALQUILO O UN RADICAL SULFONILO O SULFINILO; R3 REPRESENTA UN RADICAL FENILO, BENZOILO, - NR4R5 O PIPERIDINIL - 4 SUSTITUIDO EN POSICION - 1 POR UN RADICAL FENILALQUILO; R4 REPRESENTA UN RADICAL ALQUILO; R5 REPRESENTA UN RADICAL FENILALQUILO, N ES IGUAL A 1,2 O 3; M ES IGUAL A 0,1,2 O 3. EL INVENTO TAMBIEN DESCRIBE LAS SALES DE DICHOS COMPUESTOS, PROCESOS PARA SU PREPARACION Y MEDICAMENTOS QUE LOS CONTIENEN.
ES91910896T 1990-06-07 1991-05-31 Derivados de benzotiazol, su preparacion y los medicamentos que les contienen. Expired - Lifetime ES2057901T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9007068A FR2663029B1 (fr) 1990-06-07 1990-06-07 Derives de benzothiazole, leur preparation et les medicaments les contenant.

Publications (1)

Publication Number Publication Date
ES2057901T3 true ES2057901T3 (es) 1994-10-16

Family

ID=9397359

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910896T Expired - Lifetime ES2057901T3 (es) 1990-06-07 1991-05-31 Derivados de benzotiazol, su preparacion y los medicamentos que les contienen.

Country Status (10)

Country Link
US (1) US5340824A (es)
EP (1) EP0532602B1 (es)
JP (1) JPH05507918A (es)
AT (1) ATE109475T1 (es)
CA (1) CA2080005A1 (es)
DE (1) DE69103271T2 (es)
DK (1) DK0532602T3 (es)
ES (1) ES2057901T3 (es)
FR (1) FR2663029B1 (es)
WO (1) WO1991018892A1 (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824662A (en) 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US6413948B1 (en) 1996-09-27 2002-07-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688138B1 (fr) * 1992-03-06 1995-05-05 Rhone Poulenc Rorer Sa Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique.
DE4310523A1 (de) * 1993-03-31 1994-10-06 Basf Ag Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen
ATE291015T1 (de) * 1997-11-05 2005-04-15 Mitsubishi Chem Corp Alkylaminoderivate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492258A1 (fr) * 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
GB8820231D0 (en) * 1988-08-25 1988-09-28 Fujisawa Pharmaceutical Co New benzazole compounds processes for preparation thereof & pharmaceutical composition comprising same
DE68903484T2 (de) * 1988-12-15 1993-03-18 Rhone Poulenc Sante 2-imino-6-polyfluoralkoxy-benzothiazol-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.
FR2649701B2 (fr) * 1988-12-15 1991-11-22 Rhone Poulenc Sante Derives d'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824662A (en) 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US5985855A (en) 1996-09-27 1999-11-16 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using NAALADase inhibitors
US6004946A (en) 1996-09-27 1999-12-21 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US6413948B1 (en) 1996-09-27 2002-07-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors

Also Published As

Publication number Publication date
DE69103271T2 (de) 1994-12-22
JPH05507918A (ja) 1993-11-11
FR2663029A1 (fr) 1991-12-13
WO1991018892A1 (fr) 1991-12-12
ATE109475T1 (de) 1994-08-15
EP0532602A1 (fr) 1993-03-24
DK0532602T3 (da) 1994-09-12
US5340824A (en) 1994-08-23
DE69103271D1 (de) 1994-09-08
EP0532602B1 (fr) 1994-08-03
FR2663029B1 (fr) 1992-07-31
CA2080005A1 (fr) 1991-12-08

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