ES2057187T3 - Procedimiento para la preparacion de clorhidrato de fluoxetina. - Google Patents
Procedimiento para la preparacion de clorhidrato de fluoxetina.Info
- Publication number
- ES2057187T3 ES2057187T3 ES90100314T ES90100314T ES2057187T3 ES 2057187 T3 ES2057187 T3 ES 2057187T3 ES 90100314 T ES90100314 T ES 90100314T ES 90100314 T ES90100314 T ES 90100314T ES 2057187 T3 ES2057187 T3 ES 2057187T3
- Authority
- ES
- Spain
- Prior art keywords
- fluoxetine
- preparation
- chlorhydrate
- procedure
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002464 fluoxetine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- GIYXAJPCNFJEHY-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine hydrochloride (1:1) Chemical compound Cl.C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 GIYXAJPCNFJEHY-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960000389 fluoxetine hydrochloride Drugs 0.000 abstract 2
- LIUQUIPHRFFOIE-UHFFFAOYSA-N 3-hydroxy-n-methyl-3-phenylpropanamide Chemical compound CNC(=O)CC(O)C1=CC=CC=C1 LIUQUIPHRFFOIE-UHFFFAOYSA-N 0.000 abstract 1
- BAYGVMXZJBFEMB-UHFFFAOYSA-N 4-(trifluoromethyl)phenol Chemical compound OC1=CC=C(C(F)(F)F)C=C1 BAYGVMXZJBFEMB-UHFFFAOYSA-N 0.000 abstract 1
- GKKZMYDNDDMXSE-UHFFFAOYSA-N Ethyl 3-oxo-3-phenylpropanoate Chemical compound CCOC(=O)CC(=O)C1=CC=CC=C1 GKKZMYDNDDMXSE-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- DVIBDQWVFHDBOP-UHFFFAOYSA-N ethyl 3-hydroxy-3-phenylpropanoate Chemical compound CCOC(=O)CC(O)C1=CC=CC=C1 DVIBDQWVFHDBOP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN PROCESO PARA LA PREPARACION DE HIDROCLORIDO FLUOXETINO EN EL CUAL EL BENZOILACETATO ETIL, ES REDUCIDO A ETIL - 3 - HIDROXI - 3 - FENIL PROPIONATO (X); ES TRATADO CON METILAMINA PARA OBTENER 3 - HIDROXI - 3 - FENIL ACIDO PROPIONICO N-METIL AMIDA (XI), TRATADO ESTE COMPUESTO CON 4 - TRIFLUORO METILFENOL PARA OBTENER 3 - FENIL - 3 -(4 TRIFLUOROMETIL FENOXI) N - METIL PROPANAMIDA (XII), Y ESTE COMPUESTO SE REDUCE PARA OBTENER FLUOXETINA, DE LA CUAL, MEDIANTE TRATAMIENTO POR HCL SE OBTIENE EL HIDROCLORIDO FLUOXETINO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8919049A IT1228209B (it) | 1989-01-10 | 1989-01-10 | Procedimento per la preparazione di fluoxetina cloridrato. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2057187T3 true ES2057187T3 (es) | 1994-10-16 |
Family
ID=11154121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90100314T Expired - Lifetime ES2057187T3 (es) | 1989-01-10 | 1990-01-08 | Procedimiento para la preparacion de clorhidrato de fluoxetina. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0380924B1 (es) |
AT (1) | ATE107623T1 (es) |
DE (1) | DE69010017T2 (es) |
ES (1) | ES2057187T3 (es) |
IT (1) | IT1228209B (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2103681A1 (es) * | 1995-09-19 | 1997-09-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil - (p-trifluorometilfenoxi) propilamina. |
ES2103680A1 (es) * | 1995-08-03 | 1997-09-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometil-fenoxi)propilamina. |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL99316A (en) * | 1991-08-27 | 1995-03-15 | Teva Pharma | Production of fluoxetine and new intermediates |
US5618968A (en) * | 1993-02-05 | 1997-04-08 | Pliva Farmaceutska Kemijska, Prehrambena I Kozmeticka Industrija, Dionicko Drustvo | N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation |
ES2101650B1 (es) * | 1995-06-29 | 1998-01-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina. |
ES2101654B1 (es) * | 1995-07-24 | 1998-01-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina. |
ES2101655B1 (es) * | 1995-07-28 | 1998-01-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina. |
US5936124A (en) * | 1998-06-22 | 1999-08-10 | Sepacor Inc. | Fluoxetine process from benzoylpropionic acid |
US6025517A (en) * | 1998-08-03 | 2000-02-15 | Sepracor Inc. | Fluoxetine process from benzoylacetonitrile |
US6846957B2 (en) | 2002-11-22 | 2005-01-25 | Board Of Regents, The University Of Texas System | Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
GB2060618A (en) * | 1979-09-14 | 1981-05-07 | Wyeth John & Brother Ltd | 3-Aryl-3-Aryloxypropylamines |
-
1989
- 1989-01-10 IT IT8919049A patent/IT1228209B/it active
-
1990
- 1990-01-08 ES ES90100314T patent/ES2057187T3/es not_active Expired - Lifetime
- 1990-01-08 EP EP90100314A patent/EP0380924B1/en not_active Expired - Lifetime
- 1990-01-08 AT AT90100314T patent/ATE107623T1/de not_active IP Right Cessation
- 1990-01-08 DE DE69010017T patent/DE69010017T2/de not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2103680A1 (es) * | 1995-08-03 | 1997-09-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometil-fenoxi)propilamina. |
ES2103681A1 (es) * | 1995-09-19 | 1997-09-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil - (p-trifluorometilfenoxi) propilamina. |
Also Published As
Publication number | Publication date |
---|---|
DE69010017D1 (de) | 1994-07-28 |
EP0380924B1 (en) | 1994-06-22 |
EP0380924A1 (en) | 1990-08-08 |
ATE107623T1 (de) | 1994-07-15 |
DE69010017T2 (de) | 1994-10-06 |
IT1228209B (it) | 1991-06-05 |
IT8919049A0 (it) | 1989-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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