ES2056936T3 - Conjugado bidentado y metodo de utilizacion del mismo. - Google Patents
Conjugado bidentado y metodo de utilizacion del mismo.Info
- Publication number
- ES2056936T3 ES2056936T3 ES88309004T ES88309004T ES2056936T3 ES 2056936 T3 ES2056936 T3 ES 2056936T3 ES 88309004 T ES88309004 T ES 88309004T ES 88309004 T ES88309004 T ES 88309004T ES 2056936 T3 ES2056936 T3 ES 2056936T3
- Authority
- ES
- Spain
- Prior art keywords
- bidentate
- members
- conjugate
- specific binding
- spacer moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
UN NUEVO CONJUGADO BIDENTADO TIENE DOS PARTES QUIMICAS O MIEMBROS BIDENTADOS DIFERENTES, UNIDOS A TRAVES DE UNA PARTE ESPACIADORA ADECUADA. CADA MIEMBRO BIDENTADO ACTUA COMO UNA PEQUEÑA MOLECULA LIGANDO, Y ES CAPAZ DE UNIRSE ESPECIFICAMENTE A UNA SUSTANCIA MACROMOLECULAR. LOS MIEMBROS BIDENTADOS SON MOLECULAS RELATIVAMENTE PEQUEÑAS, HABITUALMENTE DE TAMAÑOS MENORES QUE 7000 DALTONS APROXIMADAMENTE. LA PARTE ESPACIADORA SE ELIGE DE MODO QUE AMBOS MIEMBROS BIDENTADOS SE PUEDAN UNIR SIMULTANEAMENTE A SU RESPECTIVA PAREJA ENLAZANTE ESPECIFICA. CUANDO LAS PAREJAS ENLAZANTES ESPECIFICAS SON MULTIVALENTES, SE PUEDEN FORMAR GRANDES COMPLEJOS. LA FORMACION DE ESTOS COMPLEJOS SE PUEDE INHIBIR POR LA PRESENCIA DE UN MIEMBRO BIDENTADO MONOVALENTE NO CONJUGADO, TAL COMO UN ANALITO LIBRE DE UNA MUESTRA DE ENSAYO. EL BIDENTADO ES DE USO PARTICULAR EN PROCEDIMIENTOS DE ENSAYO DE INHIBICION TURBIDIMETRICOS O NEFELOMETRICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10323787A | 1987-09-30 | 1987-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2056936T3 true ES2056936T3 (es) | 1994-10-16 |
Family
ID=22294106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88309004T Expired - Lifetime ES2056936T3 (es) | 1987-09-30 | 1988-09-29 | Conjugado bidentado y metodo de utilizacion del mismo. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0315317B2 (es) |
JP (1) | JP2670696B2 (es) |
AT (1) | ATE92632T1 (es) |
AU (1) | AU621321B2 (es) |
DE (1) | DE3882904T2 (es) |
ES (1) | ES2056936T3 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534620A (en) * | 1987-09-30 | 1996-07-09 | Beckman Instruments, Inc. | Method of heterogenous purification using a bidentate conjugate |
DE4011601A1 (de) * | 1990-04-10 | 1991-10-17 | Boehringer Mannheim Gmbh | Hapten-biotin-konjugate und ihre verwendung |
US5371021A (en) * | 1992-07-17 | 1994-12-06 | Beckman Instruments, Inc. | Initial rate photometric method for immunoassay |
US5440023A (en) * | 1992-09-18 | 1995-08-08 | Beckman Instruments, Inc. | Method for making valproic acid derivatives |
DE69331570T2 (de) * | 1992-10-21 | 2002-10-02 | Dade Behring Inc | Agglutinationstest unter Anwendung eines multivalenten Liganden |
CA2130170A1 (en) * | 1993-01-06 | 1994-07-21 | Josephine M. Michael | Method for making a preconjugate |
US5728589A (en) * | 1993-08-24 | 1998-03-17 | Wako Pure Chemical Industries, Ltd. | Immunoassay method |
US5747352A (en) * | 1994-05-23 | 1998-05-05 | Beckman Instruments, Inc. | Reagents and methods for the rapid and quantitative assay of pharmacological agents |
US5627080A (en) * | 1994-07-29 | 1997-05-06 | Beckman Instruments, Inc. | Detergent-facilitated immunoassay for the rapid and quantitative assay of pharmacological agents |
US6656694B2 (en) * | 2001-01-11 | 2003-12-02 | Theravance, Inc. | Method for identifying a ligand for a biological substrate |
GB0303919D0 (en) * | 2003-02-20 | 2003-03-26 | Purely Proteins Ltd | Methods for investigating the specificity of compounds that interact with receptors |
JP4780405B2 (ja) * | 2006-08-29 | 2011-09-28 | アイシン精機株式会社 | 結合親和性を利用する被検物質の測定方法、及び被検物質の測定のための結合親和性解析の制御方法 |
CN113030463B (zh) * | 2021-02-04 | 2023-08-11 | 北京邦腾生物科技有限公司 | 一种检测疫苗中蛋白a等杂质的试纸条及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2029011B (en) * | 1978-09-01 | 1983-02-02 | Coulson W | Use of a synthetic bifunctional ligand for the immunimetric determination of the concentration ratio of two solutes |
ATE78100T1 (de) * | 1984-11-27 | 1992-07-15 | Behringwerke Ag | Bifunktionelle haptene, verfahren zu ihrer herstellung und ihre verwendung. |
US4680338A (en) * | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
-
1988
- 1988-09-29 DE DE88309004T patent/DE3882904T2/de not_active Expired - Fee Related
- 1988-09-29 AT AT88309004T patent/ATE92632T1/de not_active IP Right Cessation
- 1988-09-29 EP EP88309004A patent/EP0315317B2/en not_active Expired - Lifetime
- 1988-09-29 ES ES88309004T patent/ES2056936T3/es not_active Expired - Lifetime
- 1988-09-30 JP JP63508689A patent/JP2670696B2/ja not_active Expired - Lifetime
- 1988-09-30 AU AU26032/88A patent/AU621321B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0315317B1 (en) | 1993-08-04 |
EP0315317A3 (en) | 1989-05-24 |
ATE92632T1 (de) | 1993-08-15 |
EP0315317A2 (en) | 1989-05-10 |
JPH02501410A (ja) | 1990-05-17 |
WO1989003042A1 (en) | 1989-04-06 |
EP0315317B2 (en) | 2000-05-10 |
DE3882904D1 (de) | 1993-09-09 |
AU2603288A (en) | 1989-04-18 |
JP2670696B2 (ja) | 1997-10-29 |
DE3882904T2 (de) | 1993-11-18 |
AU621321B2 (en) | 1992-03-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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