ES2055371T3 - Derivados de fenotiazina, su preparacion y las composiciones farmaceuticas que les contienen. - Google Patents

Derivados de fenotiazina, su preparacion y las composiciones farmaceuticas que les contienen.

Info

Publication number
ES2055371T3
ES2055371T3 ES90402602T ES90402602T ES2055371T3 ES 2055371 T3 ES2055371 T3 ES 2055371T3 ES 90402602 T ES90402602 T ES 90402602T ES 90402602 T ES90402602 T ES 90402602T ES 2055371 T3 ES2055371 T3 ES 2055371T3
Authority
ES
Spain
Prior art keywords
alkyl
optionally substituted
denotes
general formula
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402602T
Other languages
English (en)
Inventor
Claude Garret
Claude Guyon
Bernard Plau
Gerard Taurand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Application granted granted Critical
Publication of ES2055371T3 publication Critical patent/ES2055371T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NUEVOS DERIVADOS DE LA FENOTIAZINA DE FORMULA GENERAL (I) EN LA CUAL R REPRESENTA CICLOALCOHILO CONTENIENDO DE 4 A 6 ESLABONES, O REPRESENTA -CH2R" EN LA CUAL R" ES HIDROGENO, ALCOHILO CONTENIENDO DE 1 A 5 ATOMOS DE CARBONO, ALCENILO O ALCINILO CONTENIENDO DE 2 A 4 ATOMOS DE CARBONO, CICLOALCOHILO (3 A 6 ESLABONES) FENILO EVENTUALMENTE SUSTITUIDO (POR 1 O 2 ATOMOS DE HALOGENO O POR UN RADICAL HIDROXI, ALCOHILO, ALCOHILOXI, TRIFLUOROMETILO O NITRO) O HETEROCICLILO ESCOGIDO ENTRE FURILO, TIENILO O PIRIDILO, Y R1 REPRESENTA UN RADICAL DE FORMULA GENERAL (IIA) EN LA CUAL R1 Y R2 IDENTICOS O DIFERENTES SON ALCOHILO, CICLOALCOHILO, HIDROXIALCOHILO, ACETILOXIALCOHILO O FORMANDO CONJUNTO CON EL ATOMO DE NITROGENO AL CUAL SON AGREGADOS, UN TEREROCICLO SATURADO O PARCIALMENTE INSATURADO CONTENIENDO DE 4 A 7 ESLABONES Y EVENTUALMENTE SUSTITUIDO POR 1 O 2 RADICALES ALCOHILO, HIDROXIALCOHILO O ACETILOXIALCOHILO, Y R3 ES FENETILO O ALCOHILO EVENTUALMENTE SUSTITUIDO POR CICLOALCOHILO C3 A 6 O BENZOILO, UNRADICAL DE FORMULA GENERAL (IIB) EN LA CUAL R1 Y R2 ESTAN DEFINIDOS COMO ANTERIORMENTE SE HA DICHO. LOS NUEVOS PRODUCTOS SON UTILES COMO ANTIESPASMODICOS.
ES90402602T 1989-09-21 1990-09-20 Derivados de fenotiazina, su preparacion y las composiciones farmaceuticas que les contienen. Expired - Lifetime ES2055371T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912403A FR2652084B1 (fr) 1989-09-21 1989-09-21 Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2055371T3 true ES2055371T3 (es) 1994-08-16

Family

ID=9385726

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402602T Expired - Lifetime ES2055371T3 (es) 1989-09-21 1990-09-20 Derivados de fenotiazina, su preparacion y las composiciones farmaceuticas que les contienen.

Country Status (9)

Country Link
US (1) US5321026A (es)
EP (1) EP0419360B1 (es)
JP (1) JPH03120261A (es)
AT (1) ATE90087T1 (es)
CA (1) CA2025930A1 (es)
DE (1) DE69001794T2 (es)
DK (1) DK0419360T3 (es)
ES (1) ES2055371T3 (es)
FR (1) FR2652084B1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689013B1 (fr) * 1992-03-30 1995-05-05 Rhone Poulenc Rorer Sa Nouvelle application thérapeutique des dérivés de la phénothiazine.
FR2720940A1 (fr) * 1994-06-13 1995-12-15 Rhone Poulenc Rorer Sa Application du (+)-N-propyl [(pyrrolidinyl-1)-1 propyl-2]-10 phénothiazinecarboxamide comme antidépresseur.
US6284279B1 (en) 1999-12-03 2001-09-04 Avecia, Inc. Phenothiazine in prill form and method for making the same
DE10032137B4 (de) * 2000-07-01 2009-04-02 Allessachemie Gmbh Verfahren zur Herstellung von Phenothiazin-Granulat mit verbesserten Eigenschaften

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956996A (en) * 1960-10-18 Alkylated phenotfflazenecarboxamede
GB860330A (en) * 1958-04-23 1961-02-01 Rhone Poulenc Sa Improvements in or relating to phenthiazine derivatives
US3112310A (en) * 1962-01-15 1963-11-26 Searle & Co 10-alkylaminoalkylphenothiazine-2-carboxamides
FR2632520B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Derives de la phenothiazine analgesiques
FR2632521B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2632522B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
US5321026A (en) 1994-06-14
JPH03120261A (ja) 1991-05-22
FR2652084B1 (fr) 1991-10-31
EP0419360A1 (fr) 1991-03-27
FR2652084A1 (fr) 1991-03-22
DE69001794T2 (de) 1993-09-30
ATE90087T1 (de) 1993-06-15
DK0419360T3 (da) 1993-08-16
CA2025930A1 (fr) 1991-03-22
DE69001794D1 (de) 1993-07-08
EP0419360B1 (fr) 1993-06-02

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