ES2053736T3 - Un procedimiento para la preparacion de un derivado de ergolina. - Google Patents

Un procedimiento para la preparacion de un derivado de ergolina.

Info

Publication number
ES2053736T3
ES2053736T3 ES88305695T ES88305695T ES2053736T3 ES 2053736 T3 ES2053736 T3 ES 2053736T3 ES 88305695 T ES88305695 T ES 88305695T ES 88305695 T ES88305695 T ES 88305695T ES 2053736 T3 ES2053736 T3 ES 2053736T3
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
carbon atoms
atom
ergoline derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88305695T
Other languages
English (en)
Inventor
Sergio Mantegani
Enzo Brambilla
Aldemio Temperilli
Daniela Ruggieri
Patricia Salvati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of ES2053736T3 publication Critical patent/ES2053736T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Control Of Electric Motors In General (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN DERIVADO DE ERGOLONA DE FORMULA (I) DONDE LOS SUSTITUYENTES TIENENEL SIGNIFICADO QUE SE INDICA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE DICHO DERIVADOS DE RGOLINA; EL COMPUESTO ES UN AGENTE ANTIHIPERTENSIVO.
ES88305695T 1987-06-24 1988-06-22 Un procedimiento para la preparacion de un derivado de ergolina. Expired - Lifetime ES2053736T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878714767A GB8714767D0 (en) 1987-06-24 1987-06-24 Egoline derivatives

Publications (1)

Publication Number Publication Date
ES2053736T3 true ES2053736T3 (es) 1994-08-01

Family

ID=10619460

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88305695T Expired - Lifetime ES2053736T3 (es) 1987-06-24 1988-06-22 Un procedimiento para la preparacion de un derivado de ergolina.

Country Status (19)

Country Link
US (1) US4859678A (es)
EP (1) EP0296830B1 (es)
JP (1) JPS6422875A (es)
KR (1) KR960015965B1 (es)
AT (1) ATE85336T1 (es)
AU (1) AU609144B2 (es)
CA (1) CA1293247C (es)
DE (1) DE3878052T2 (es)
DK (1) DK341988A (es)
ES (1) ES2053736T3 (es)
FI (1) FI88301C (es)
GB (1) GB8714767D0 (es)
HU (1) HU197743B (es)
IE (1) IE63372B1 (es)
IL (1) IL86795A (es)
NZ (1) NZ225099A (es)
PT (1) PT87790B (es)
SU (1) SU1634137A3 (es)
ZA (1) ZA884451B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69330601T2 (de) * 1992-12-24 2002-07-04 Pharmacia & Upjohn Spa Serotoninergische ergolin derivate
GB9407637D0 (en) 1994-04-18 1994-06-08 Erba Carlo Spa Serotoninergic abeo-ergoline derivatives
GB9603226D0 (en) * 1996-02-15 1996-04-17 Pharmacia Spa Heterocyclyl-ergoline derivatives
US6060483A (en) * 1996-06-27 2000-05-09 Pharmacia & Upjohn S.P.A. Antineurodegenerative ergoline derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2120242A (en) * 1982-04-30 1983-11-30 Erba Farmitalia Ergoline derivatives
DE3323119A1 (de) * 1982-09-03 1984-03-08 Farmitalia Carlo Erba S.p.A., 20159 Milano 7-cyano-ergoline
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
NL8700046A (nl) * 1986-01-24 1987-08-17 Sandoz Ag 8 alfa-acylaminoergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
DE3700825A1 (de) * 1986-01-24 1987-07-30 Sandoz Ag 8(alpha)-acylaminoergoline, ihre herstellung und verwendung
GB8617907D0 (en) * 1986-07-22 1986-08-28 Erba Farmitalia Tetracyclic indole derivatives

Also Published As

Publication number Publication date
KR890000478A (ko) 1989-03-14
PT87790A (pt) 1988-07-01
FI88301C (fi) 1993-04-26
PT87790B (pt) 1992-10-30
HU197743B (en) 1989-05-29
DE3878052D1 (de) 1993-03-18
ATE85336T1 (de) 1993-02-15
IL86795A (en) 1991-11-21
FI88301B (fi) 1993-01-15
FI882978A0 (fi) 1988-06-22
IL86795A0 (en) 1988-11-30
NZ225099A (en) 1990-09-26
JPS6422875A (en) 1989-01-25
US4859678A (en) 1989-08-22
GB8714767D0 (en) 1987-07-29
HUT46913A (en) 1988-12-28
ZA884451B (en) 1989-05-30
AU609144B2 (en) 1991-04-26
DK341988A (da) 1988-12-25
IE881862L (en) 1988-12-24
SU1634137A3 (ru) 1991-03-07
CA1293247C (en) 1991-12-17
EP0296830A2 (en) 1988-12-28
DK341988D0 (da) 1988-06-22
IE63372B1 (en) 1995-04-19
AU1818688A (en) 1989-01-05
DE3878052T2 (de) 1993-05-19
KR960015965B1 (ko) 1996-11-25
FI882978A (fi) 1988-12-25
EP0296830B1 (en) 1993-02-03
EP0296830A3 (en) 1989-12-06

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