ES2052595T3 - Nuevos derivados peptidicos y su aplicacion en especial en terapeutica. - Google Patents

Nuevos derivados peptidicos y su aplicacion en especial en terapeutica.

Info

Publication number
ES2052595T3
ES2052595T3 ES87402845T ES87402845T ES2052595T3 ES 2052595 T3 ES2052595 T3 ES 2052595T3 ES 87402845 T ES87402845 T ES 87402845T ES 87402845 T ES87402845 T ES 87402845T ES 2052595 T3 ES2052595 T3 ES 2052595T3
Authority
ES
Spain
Prior art keywords
therapeutics
orn
application
derivatives
trp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87402845T
Other languages
English (en)
Spanish (es)
Inventor
De Rotrou Gerard Arm Marguerie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Santé et de la Recherche Médicale
Cephalon France SAS
Original Assignee
Institut National de la Santé et de la Recherche Médicale
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8617507A external-priority patent/FR2608160B1/fr
Priority claimed from FR8708986A external-priority patent/FR2617169B1/fr
Application filed by Institut National de la Santé et de la Recherche Médicale, Laboratoire L Lafon SA filed Critical Institut National de la Santé et de la Recherche Médicale
Application granted granted Critical
Publication of ES2052595T3 publication Critical patent/ES2052595T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ES87402845T 1986-12-15 1987-12-14 Nuevos derivados peptidicos y su aplicacion en especial en terapeutica. Expired - Lifetime ES2052595T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8617507A FR2608160B1 (fr) 1986-12-15 1986-12-15 Nouveaux derives peptidiques et leur application notamment en therapeutique
FR8708986A FR2617169B1 (fr) 1987-06-25 1987-06-25 Nouveaux derives peptidiques et leur application notamment en therapeutique

Publications (1)

Publication Number Publication Date
ES2052595T3 true ES2052595T3 (es) 1994-07-16

Family

ID=26225644

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87402845T Expired - Lifetime ES2052595T3 (es) 1986-12-15 1987-12-14 Nuevos derivados peptidicos y su aplicacion en especial en terapeutica.

Country Status (7)

Country Link
US (1) US5100875A (enExample)
EP (1) EP0275748B1 (enExample)
JP (1) JP2554346B2 (enExample)
CA (1) CA1311583C (enExample)
DE (1) DE3781263T2 (enExample)
ES (1) ES2052595T3 (enExample)
GR (1) GR3006288T3 (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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US5547936A (en) * 1985-06-17 1996-08-20 La Jolla Cancer Research Foundation Inhibition of cell migration with synthetic peptides
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5827821A (en) 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
CA1324954C (en) * 1988-03-10 1993-12-07 Erkki I. Ruoslahti Inhibition of cell migration with synthetic peptides
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
WO1990005103A1 (en) * 1988-11-03 1990-05-17 Prime Technology A sheet feeding apparatus
DE3841753A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US5686570A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5780595A (en) * 1989-06-16 1998-07-14 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5395609A (en) * 1989-06-19 1995-03-07 Antisoma Limited Synthetic peptides for use in tumor detection
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
EP0410541A1 (en) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogen receptor antagonists
US5061693A (en) * 1989-07-28 1991-10-29 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2021951A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2021952A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
NZ235563A (en) * 1989-10-13 1993-04-28 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical composition
US5338723A (en) * 1989-10-13 1994-08-16 Merck & Co., Inc. Fibrinogen receptor antagonists
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
WO1991007429A1 (en) * 1989-11-09 1991-05-30 Smithkline Beecham Corporation Anti-aggregatory peptides containing a mercaptan or sulfide moiety
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
ATE155482T1 (de) * 1990-04-06 1997-08-15 Jolla Cancer Res Found Verfahren und verbindung zur behandlung von thrombose
US5481021A (en) * 1991-03-06 1996-01-02 G. D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors
DK0578728T3 (da) * 1991-04-05 1999-04-12 Genentech Inc Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa
US5220050A (en) * 1991-05-17 1993-06-15 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
ATE228115T1 (de) * 1991-06-28 2002-12-15 Smithkline Beecham Corp Bizyklische fibrinogenantagonisten
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5625093A (en) * 1991-10-15 1997-04-29 G. D. Searle & Co. Substituted β-amino acid derivatives useful as platelet aggregation inhibitors
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
AU3064892A (en) * 1991-11-07 1993-06-07 University Of Southern California Compositions and methods for preventing adhesion formation
AU3241693A (en) * 1991-12-13 1993-07-19 G.D. Searle & Co. Phenyl amidines lactones useful as platelet aggregation inhibitors
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5264457A (en) * 1992-02-14 1993-11-23 G. D. Searle & Co. Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
AU663169B2 (en) * 1992-03-04 1995-09-28 Gyogyszerkutato Intezet Kft New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
JP3274225B2 (ja) 1992-06-03 2002-04-15 富士写真フイルム株式会社 アミノ酸誘導体及びその用途
WO1994000424A1 (en) * 1992-06-25 1994-01-06 G.D. Searle & Co. Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
FR2692899B1 (fr) * 1992-06-30 1994-08-19 Adir Nouveaux dérivés peptidiques actifs dans les processus d'adhésion cellulaire, leur procédé de préparation et les compositions pharmaceutiques qui les renferment.
JPH06192291A (ja) * 1992-09-07 1994-07-12 Nippon Steel Corp 新規ペプチドとそれを用いた血小板凝集抑制剤及び血液凝固抑制剤
US6380163B1 (en) * 1992-12-22 2002-04-30 Baxter International Inc. Peritoneal dialysis solutions with polypeptides
US5409939A (en) * 1993-02-12 1995-04-25 G. D. Searle & Co. Phenyl amidine thio derivatives useful as platelet aggregation inhibitors
GB9312315D0 (en) * 1993-06-15 1993-07-28 Poston Robin Leukocyte adhesion assay
US5612355A (en) * 1993-06-23 1997-03-18 G. D. Searle & Co. Phenyl amidine lactones useful as platelet aggregation inhibitors
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
US5677276A (en) * 1994-12-23 1997-10-14 La Jolla Cancer Research Foundation Immobilization of peptides to hyaluronate
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
SI0946185T2 (sl) * 1996-11-27 2010-08-31 Aventis Pharma Inc Farmacevtski sestavek, ki obsega spojino z anti-Xa-aktivnostjo in antagonistično spojino za agregacijo ploščic
US5872122A (en) * 1997-10-16 1999-02-16 Monsanto Company Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation
WO1999047128A1 (en) 1998-03-19 1999-09-23 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
US6037365A (en) * 1998-09-25 2000-03-14 G.D. Searle & Co. Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation
US20050159362A1 (en) * 2003-04-22 2005-07-21 Sircar Jagadish C. Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
WO2004094471A2 (en) * 2003-04-22 2004-11-04 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
WO2007055873A2 (en) * 2005-11-04 2007-05-18 Avanir Pharmaceuticals Process for the manufacture of peptide facilitators of reverse cholesterol transport
RU2596787C2 (ru) 2010-07-09 2016-09-10 БиЭйчВи ФАРМА, ИНК. Комбинированная система доставки с немедленным/замедленным высвобождением для лекарственных средств с коротким периодом полувыведения, в том числе для ремоглифлозина
WO2015103643A2 (en) * 2014-01-06 2015-07-09 The General Hospital Corporation Integrin antagonists
CN112430254B (zh) * 2020-11-25 2021-10-26 广东海洋大学 一种抗凝血活性肽衍生物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
DE3421614A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives

Also Published As

Publication number Publication date
GR3006288T3 (enExample) 1993-06-21
JP2554346B2 (ja) 1996-11-13
CA1311583C (en) 1992-12-15
DE3781263T2 (de) 1993-04-08
JPS63215696A (ja) 1988-09-08
US5100875A (en) 1992-03-31
DE3781263D1 (de) 1992-09-24
EP0275748B1 (fr) 1992-08-19
EP0275748A1 (fr) 1988-07-27

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