ES2052449B1 - NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE. - Google Patents

NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE.

Info

Publication number
ES2052449B1
ES2052449B1 ES9202595A ES9202595A ES2052449B1 ES 2052449 B1 ES2052449 B1 ES 2052449B1 ES 9202595 A ES9202595 A ES 9202595A ES 9202595 A ES9202595 A ES 9202595A ES 2052449 B1 ES2052449 B1 ES 2052449B1
Authority
ES
Spain
Prior art keywords
preparation
new procedure
ethyl apovincaminate
apovincaminate
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9202595A
Other languages
Spanish (es)
Other versions
ES2052449A1 (en
Inventor
Mondelo Fernando Calvo
Ferrero M Teresa Manresa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covex SA
Original Assignee
Covex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covex SA filed Critical Covex SA
Priority to ES9202595A priority Critical patent/ES2052449B1/en
Priority to HU9301983A priority patent/HU209927B/en
Priority to CZ138493A priority patent/CZ279608B6/en
Priority to PL29969293A priority patent/PL171090B1/en
Priority to SK756-93A priority patent/SK278851B6/en
Priority to RO9301002A priority patent/RO110500B1/en
Priority to BG97969A priority patent/BG61305B1/en
Publication of ES2052449A1 publication Critical patent/ES2052449A1/en
Application granted granted Critical
Publication of ES2052449B1 publication Critical patent/ES2052449B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

NUEVO PROCEDIMIENTO PARA LA PREPARACION DEL APOVINCAMINATO DE ETILO. COMPRENDE: HACER REACCIONAR ACIDO APOVINCAMINICO (II) CON ETANOLEN PRESENCIA DE UN CATALIZADOR DE FORMULA (III) EN LA QUE X = -OCH3, -COCH3, -NO2, -CH3 Y -CN. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO POLAR, EN PRESENCIA DE UNA BASE ORGANICA Y A TEMPERATURA AMBIENTE. EL APOVINCAMINATO DE ETILO (I) TIENE APLICACION EN EL TRATAMIENTO DE LOS TRASTORNOS CEREBRALES Y EN GERIATRIA.NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE. UNDERSTANDS: REACTION OF APOVINCAMINIC ACID (II) WITH ETHANOLEN PRESENCE OF A FORMULA (III) CATALYST IN WHICH X = -OCH3, -COCH3, -NO2, -CH3 AND -CN. THE REACTION IS CARRIED OUT IN A POLAR ORGANIC SOLVENT, IN THE PRESENCE OF AN ORGANIC BASE AND AT ROOM TEMPERATURE. THE ETHYL APOVINCAMINATE (I) HAS AN APPLICATION IN THE TREATMENT OF BRAIN DISORDERS AND IN GERIATRIA.

ES9202595A 1992-12-22 1992-12-22 NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE. Expired - Lifetime ES2052449B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES9202595A ES2052449B1 (en) 1992-12-22 1992-12-22 NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE.
HU9301983A HU209927B (en) 1992-12-22 1993-07-09 Process for the preparation of ethyl apovincaminate
CZ138493A CZ279608B6 (en) 1992-12-22 1993-07-12 Process for preparing ethylapovincaminate
PL29969293A PL171090B1 (en) 1992-12-22 1993-07-15 Method of obtaining ethyl apovincaminate
SK756-93A SK278851B6 (en) 1992-12-22 1993-07-16 Method for producing ethyl apovincaminate
RO9301002A RO110500B1 (en) 1992-12-22 1993-07-16 Ethyl apovincaminate preparation process
BG97969A BG61305B1 (en) 1992-12-22 1993-07-20 New method for the preparation of ethyl apovincaminate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202595A ES2052449B1 (en) 1992-12-22 1992-12-22 NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE.

Publications (2)

Publication Number Publication Date
ES2052449A1 ES2052449A1 (en) 1994-07-01
ES2052449B1 true ES2052449B1 (en) 1995-02-16

Family

ID=8279195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202595A Expired - Lifetime ES2052449B1 (en) 1992-12-22 1992-12-22 NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE.

Country Status (7)

Country Link
BG (1) BG61305B1 (en)
CZ (1) CZ279608B6 (en)
ES (1) ES2052449B1 (en)
HU (1) HU209927B (en)
PL (1) PL171090B1 (en)
RO (1) RO110500B1 (en)
SK (1) SK278851B6 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459799A1 (en) * 1979-06-22 1981-01-16 Synthelabo SYNTHESIS OF () -VINCAMINE
HU180930B (en) * 1979-12-28 1983-05-30 Richter Gedeon Vegyeszet Process for producing ester-derivatives of halogenovincaminic acid
HU183207B (en) * 1980-09-10 1984-04-28 Richter Gedeon Vegyeszet Process for preparing apovincaminic acid esters
ES506309A0 (en) * 1981-10-16 1983-11-01 Elmu Sa PROCEDURE FOR OBTAINING AN ESTER OF THE APOVINCAMI-NICO ACID
ES8604956A1 (en) * 1985-11-20 1986-03-16 Covex Sa Process for the obtention of the ethyl ester of the apovincaminic acid
CH676002A5 (en) * 1986-05-23 1990-11-30 Arysearch Arylan Ag Ethyl apo:vincaminate prepn. - by esterification of vincamine with ethanol in presence of alkali metal followed by saponification

Also Published As

Publication number Publication date
SK278851B6 (en) 1998-04-08
HUT65826A (en) 1994-07-28
CZ138493A3 (en) 1995-05-17
CZ279608B6 (en) 1995-05-17
HU9301983D0 (en) 1993-09-28
PL171090B1 (en) 1997-03-28
RO110500B1 (en) 1996-01-30
PL299692A1 (en) 1994-06-27
SK75693A3 (en) 1994-11-09
ES2052449A1 (en) 1994-07-01
HU209927B (en) 1994-12-28
BG97969A (en) 1994-04-29
BG61305B1 (en) 1997-05-30

Similar Documents

Publication Publication Date Title
BR9815026B1 (en) process for preparing a compound, and, compound.
ES2150528T3 (en) DETACHMENT COMPOSITIONS CONTAINING OTHER CROWN.
ES2196054T3 (en) DERIVATIVES OF PHENYLACETIC ACID, PROCEDURE AND INTERMEDIATE PRODUCTS FOR OBTAINING AND AGENTS CONTAINING THE SAME.
ES2102367T3 (en) AMIDAS OF ISOXAZOL-4-CARBOXILIC ACIDS AND AMIDAS OF HIDROXIALQUILIDEN-CIANOACETIC ACIDS, MEDICINES CONTAINING THESE COMPOUNDS AND THEIR USE.
BR9808827B1 (en) process for the preparation of indanones, and use of an indanone.
MX9302461A (en) BENZO-AND PIRIDOPIRIDONES SUBSTITUTED BY SULFONILBENCILO, PROCEDURE FOR THEIR OBTAINING AND MEDICINES THAT CONTAIN THEM.
MX173310B (en) PHENOLIC DERIVATIVES OF BENZOTIAZOLE AS INHIBITORS OF CORROSION
ES2052449B1 (en) NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE.
MX9305773A (en) 5-OXO-DIBENZO / A, D / CICLOHEPTA-1,4-DIENOS, PROCEDURE FOR THEIR OBTAINING AND MEDICINES THAT CONTAIN THEM.
ES2056639T3 (en) PROCEDURE FOR THE TRANSFORMATION OF ACID (BENZOIL-3 FENIL) -2 PROPIONICO-R (-) IN ISOMERO S (+).
DK449983D0 (en) PROCEDURE FOR MANUFACTURING OPTICAL ACTIVE RELATIONS
PT800520E (en) PROCESS FOR THE PREPARATION OF LAMOTRIGINE
ES2114676T3 (en) SUBSTITUTED DERIVATIVES OF ORTO-ETHENYLPHENYLACETIC ACID.
PT98599A (en) PROCESS FOR THE PRODUCTION OF A PROPYLAMINE DERIVATIVES
ATE250616T1 (en) PURIFICATION OF AN ORGANIC METAL COMPOUND BY RECRYSTALLIZATION
IT1210910B (en) IMPROVEMENT OF THE PROCEDURE TO PREPARE BIARYL COMPOUNDS BY COPULATION OF AN ARILAMINE WITH AN ARENE.
ES2053686T3 (en) NEW DI (MET) ACRYLATES, PROCEDURE FOR ITS MANUFACTURE AND EMPLOYMENT.
ES2052464T3 (en) PREPARATION PROCEDURE OF 5-ALCOXI-2,4-DINITRO-ALQUIL-BENCENOS.
ES2035105T3 (en) PROCEDURE FOR THE PREPARATION OF N-ALKYL DERIVATIVES OF 2-AMINO-6,7-DIMETOXI TETRALINA.
ATE18212T1 (en) SUBSTITUTED 1-BENZOYL-2-PHENYLIMINOIMIDAZOLIDINES, THEIR ACID ADDITIONAL SALTS, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING THEM.
ES2171997T3 (en) PROCEDURE FOR CONVERSION OF HETROAROMATIC HIDROXI IN ARILAMINAS.
ES2032059T3 (en) PROCEDURE FOR OBTAINING DERIVATIVES OF 2-CIANO-3-AMINOACRILONITRILO.
ES2099014B1 (en) NEW CHEMICAL OXIME ETERES DERIVED FROM LIMONENE, PROCEDURE FOR ITS PREPARATION AND APPLICATIONS.
AR245930A1 (en) New process for the synthesis of the n.-methyl-3,4- dimethoxyphenylethylamine
ES8609198A1 (en) Prepn. of acetyl-cinnamate intermediates