ES2051738T3 - Derivados aminicos de compuestos analogos a acido folico. - Google Patents

Derivados aminicos de compuestos analogos a acido folico.

Info

Publication number
ES2051738T3
ES2051738T3 ES87304093T ES87304093T ES2051738T3 ES 2051738 T3 ES2051738 T3 ES 2051738T3 ES 87304093 T ES87304093 T ES 87304093T ES 87304093 T ES87304093 T ES 87304093T ES 2051738 T3 ES2051738 T3 ES 2051738T3
Authority
ES
Spain
Prior art keywords
conjugates
folic acid
antibody
vivo
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87304093T
Other languages
English (en)
Inventor
Daniel J Coughlin
Anthony Dwight Lopes
Robert D Radcliffe
John D Rodwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytogen Corp
Original Assignee
Cytogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytogen Corp filed Critical Cytogen Corp
Application granted granted Critical
Publication of ES2051738T3 publication Critical patent/ES2051738T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE PRESENTAN NUEVOS CONJUGADOS DE ANTICUERPOS TERAPEUTICOS QUE COMPRENDEN DERIVADOS AMINOS DE ACIDO FOLICO ENLAZADOS COVALENTEMENTE POR MEDIO DE UN GRUPO AMINO REACTIVO A UNA MOLECULA DE CARBOHIDRATO OXIDADA DE UN ANTICUERPO O FRAGMENTO DE ANTICUERPO. LOS COJUNGADOS RETIENEN SUSTANCIALMENTE LA MISMA INMUNOESPECIFICIVIDAD E INMUNOREACTIVIDAD DE LA MOLECULA DE ANTICUERPO NO CONJUGADO. LA INMUNOESPECIFICIVIDAD Y LA INMUNOREACTIVIDAD DE LOS CONJUGADOS DEL ANTICUERPO PERMITEN LA LIBERACION DEL DERIVADO AMINO ENLAZADO TERAPEUTICAMENTE EFECTIVO DEL ACIDO FOLICO IN VIVO. LOS CONJUGADOS SON TERAPEUTICAMENTE EFECTIVOS CONTRA UNA VARIEDAD DE DESORDENES CELULARES NEOPLASTICOS Y NO NEOPLASTICOS CUANDO SE ADMINISTRA IN VIVO. TAMBIEN SE HAN DESCUBIERTO METODOS PARA LA SINTETIZACION DE LOS DERIVADOS AMINO DEL ACIDO FOLICO, METODOS PARA LA PREPARACION DE CONJUGADOS DE ANTICUERPO Y METODOS PARA EL USO DE LOS CONJUGADOS IN VIVO.
ES87304093T 1986-05-08 1987-05-07 Derivados aminicos de compuestos analogos a acido folico. Expired - Lifetime ES2051738T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86103786A 1986-05-08 1986-05-08

Publications (1)

Publication Number Publication Date
ES2051738T3 true ES2051738T3 (es) 1994-07-01

Family

ID=25334695

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87304093T Expired - Lifetime ES2051738T3 (es) 1986-05-08 1987-05-07 Derivados aminicos de compuestos analogos a acido folico.

Country Status (11)

Country Link
EP (1) EP0251455B1 (es)
JP (1) JP2564586B2 (es)
AT (1) ATE105484T1 (es)
AU (1) AU7359087A (es)
CA (1) CA1330378C (es)
DE (1) DE3789788T2 (es)
DK (1) DK5188A (es)
ES (1) ES2051738T3 (es)
FI (1) FI880059A (es)
WO (1) WO1987006837A1 (es)
ZA (1) ZA873305B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK8189A (da) * 1988-01-12 1989-07-13 Bunge Australia Antigen-antistof-konjugater, deres fremstilling og anvendelse
US5028697A (en) * 1988-08-08 1991-07-02 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
US5144012A (en) * 1988-08-08 1992-09-01 Eli Lilly And Company Cytotoxic drug conjugates
EP0434765B1 (en) * 1988-09-30 1995-11-08 Neorx Corporation Targeting substance-diagnostic/therapeutic agent conjugates having schiff base linkages
US5066789A (en) * 1988-09-30 1991-11-19 Neorx Corporation Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages
EP0444158B1 (en) * 1988-11-18 1996-01-03 The Regents Of The University Of California Conjugated polypeptides and methods for their preparation and use
US5157123A (en) * 1989-03-13 1992-10-20 Georgetown University S-(2-thiopyridyl)-l-cysteine, a heterobifunctional crosslinking reagent
US5208008A (en) * 1990-11-14 1993-05-04 University Of Pittsburgh Regioselective chemical modification of monoclonal antibodies
US5547668A (en) * 1995-05-05 1996-08-20 The Board Of Trustees Of The University Of Illinois Conjugates of folate anti-effector cell antibodies
DK0879604T3 (da) * 1997-05-09 2003-08-04 Deutsches Krebsforsch Konjugat omfattende en folinsyreantagonist og en bærer
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9518087B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
JP6744227B2 (ja) 2014-02-21 2020-08-19 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ（ウペエフエル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ ｄｅ Ｌａｕｓａｎｎｅ （ＥＰＦＬ） 糖標的化治療剤
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10309959B2 (en) 2014-12-03 2019-06-04 Life Technologies Corporation Charged reactive oligomers
US10246410B2 (en) 2014-12-03 2019-04-02 Life Technologies Corporation Hydrazinyl and aminooxy compounds and their methods of use
WO2018232176A1 (en) 2017-06-16 2018-12-20 The University Of Chicago Compositions and methods for inducing immune tolerance

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595101A (en) * 1977-03-15 1981-08-05 Hoffmann La Roche Enzyme modifier immunoassay
FR2402664A1 (fr) * 1977-09-07 1979-04-06 Agronomique Inst Nat Rech Produits de couplage phosphorylcholine, composes amines procede d'obtention et applications
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
CA1203164A (en) * 1982-03-09 1986-04-15 Thomas J. Mckearn Antibody conjugates
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4584375A (en) * 1984-08-21 1986-04-22 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutamate formation
AU583854B2 (en) * 1984-09-13 1989-05-11 Cytogen Corporation Antibody therapeutic agent conjugates

Also Published As

Publication number Publication date
AU7359087A (en) 1987-12-01
EP0251455A2 (en) 1988-01-07
ZA873305B (en) 1987-11-02
CA1330378C (en) 1994-06-21
DE3789788D1 (de) 1994-06-16
EP0251455A3 (en) 1990-09-05
EP0251455B1 (en) 1994-05-11
DK5188D0 (da) 1988-01-07
WO1987006837A1 (en) 1987-11-19
JPS63503144A (ja) 1988-11-17
JP2564586B2 (ja) 1996-12-18
ATE105484T1 (de) 1994-05-15
FI880059A0 (fi) 1988-01-07
FI880059A (fi) 1988-01-07
DE3789788T2 (de) 1994-08-18
DK5188A (da) 1988-04-15

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