ES2050613A1 - Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico. - Google Patents
Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.Info
- Publication number
- ES2050613A1 ES2050613A1 ES09202059A ES9202059A ES2050613A1 ES 2050613 A1 ES2050613 A1 ES 2050613A1 ES 09202059 A ES09202059 A ES 09202059A ES 9202059 A ES9202059 A ES 9202059A ES 2050613 A1 ES2050613 A1 ES 2050613A1
- Authority
- ES
- Spain
- Prior art keywords
- give
- cyclopropyl
- preparation
- acid derivatives
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NUEVO PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO 1-CICLOPROPIL-3-QUINOLINCARBOXILICO. COMPRENDE A) HACER REACCIONAR 3-CLORO-4-FLUORANILINA (II) CON 1-BROMO-1-ETOXICICLOPROPANO (III) PARA DAR (IV), B) REDUCIR (IV) CON BOROHIDRURO SODICO PARA DAR (V); C) HACER REACCIONAR (V) CON ETOXIMETILENMALONATO DE DIETILO PARA DAR (VI); D) SOMETER (VI) A CICLACION TERMICA PARA DAR (VII); E) SOMETER (VII) A HIDROLISIS ALCALINA PARA DAR (VIII); F) HACER REACCIONAR (VIII) CON (IX) PARA DAR (I). EN LAS FORMULAS X=N,O,S; R1=H,CH3; R2=H,CH3,C2H5,C3H7; Y R3=H,CH3). LOS COMPUESTOS DE FORMULA (I) TIENEN APLICACION COMO POTENTES AGENTES ANTIBACTERIANOS, ACTIVOS FRENTE A GERMENES GRAM NEGATIVOS, EN ESPECIAL, Y FRENTE A ALGUNOS GERMENES GRAM POSITIVOS.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9202059A ES2050613B1 (es) | 1992-10-16 | 1992-10-16 | Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9202059A ES2050613B1 (es) | 1992-10-16 | 1992-10-16 | Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2050613A1 true ES2050613A1 (es) | 1994-05-16 |
ES2050613B1 ES2050613B1 (es) | 1996-03-16 |
Family
ID=8278449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9202059A Expired - Lifetime ES2050613B1 (es) | 1992-10-16 | 1992-10-16 | Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2050613B1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110122493A (zh) * | 2019-06-14 | 2019-08-16 | 山东省联合农药工业有限公司 | 喹诺酮类化合物用于防治有用植物中细菌性有害生物的用途 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8307787A1 (es) * | 1981-10-29 | 1983-07-16 | Bayer Ag | Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos. |
EP0274033A1 (de) * | 1986-12-03 | 1988-07-13 | Bayer Ag | Verfahren zur Herstellung von Chinolincarbonsäuren |
EP0332033A2 (de) * | 1988-03-11 | 1989-09-13 | Bayer Ag | N-Cyclopropylaniline und deren Verwendung in Verfahren zur Herstellung von 1-Cyclopropyl-chinoloncarbonsäuren und deren Derivaten |
EP0343574A1 (en) * | 1988-05-24 | 1989-11-29 | Kirin Beer Kabushiki Kaisha | 4(1H)-quinolone derivatives |
ES2010948A6 (es) * | 1989-04-27 | 1989-12-01 | Cenavisa S A | Un procedimiento para la preparacion de derivados del acido 3-quinolincarboxilico. |
EP0348088A1 (en) * | 1988-06-21 | 1989-12-27 | Pfizer Inc. | 6-Fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor |
-
1992
- 1992-10-16 ES ES9202059A patent/ES2050613B1/es not_active Expired - Lifetime
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8307787A1 (es) * | 1981-10-29 | 1983-07-16 | Bayer Ag | Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos. |
EP0274033A1 (de) * | 1986-12-03 | 1988-07-13 | Bayer Ag | Verfahren zur Herstellung von Chinolincarbonsäuren |
EP0332033A2 (de) * | 1988-03-11 | 1989-09-13 | Bayer Ag | N-Cyclopropylaniline und deren Verwendung in Verfahren zur Herstellung von 1-Cyclopropyl-chinoloncarbonsäuren und deren Derivaten |
EP0343574A1 (en) * | 1988-05-24 | 1989-11-29 | Kirin Beer Kabushiki Kaisha | 4(1H)-quinolone derivatives |
EP0348088A1 (en) * | 1988-06-21 | 1989-12-27 | Pfizer Inc. | 6-Fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor |
ES2010948A6 (es) * | 1989-04-27 | 1989-12-01 | Cenavisa S A | Un procedimiento para la preparacion de derivados del acido 3-quinolincarboxilico. |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110122493A (zh) * | 2019-06-14 | 2019-08-16 | 山东省联合农药工业有限公司 | 喹诺酮类化合物用于防治有用植物中细菌性有害生物的用途 |
Also Published As
Publication number | Publication date |
---|---|
ES2050613B1 (es) | 1996-03-16 |
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