ES2050613A1 - Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico. - Google Patents

Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.

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Publication number
ES2050613A1
ES2050613A1 ES09202059A ES9202059A ES2050613A1 ES 2050613 A1 ES2050613 A1 ES 2050613A1 ES 09202059 A ES09202059 A ES 09202059A ES 9202059 A ES9202059 A ES 9202059A ES 2050613 A1 ES2050613 A1 ES 2050613A1
Authority
ES
Spain
Prior art keywords
give
cyclopropyl
preparation
acid derivatives
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09202059A
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English (en)
Other versions
ES2050613B1 (es
Inventor
Bazaco Joan Freixas
Coca Concepto Martorell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iteve S A
Original Assignee
Iteve S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iteve S A filed Critical Iteve S A
Priority to ES9202059A priority Critical patent/ES2050613B1/es
Publication of ES2050613A1 publication Critical patent/ES2050613A1/es
Application granted granted Critical
Publication of ES2050613B1 publication Critical patent/ES2050613B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NUEVO PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO 1-CICLOPROPIL-3-QUINOLINCARBOXILICO. COMPRENDE A) HACER REACCIONAR 3-CLORO-4-FLUORANILINA (II) CON 1-BROMO-1-ETOXICICLOPROPANO (III) PARA DAR (IV), B) REDUCIR (IV) CON BOROHIDRURO SODICO PARA DAR (V); C) HACER REACCIONAR (V) CON ETOXIMETILENMALONATO DE DIETILO PARA DAR (VI); D) SOMETER (VI) A CICLACION TERMICA PARA DAR (VII); E) SOMETER (VII) A HIDROLISIS ALCALINA PARA DAR (VIII); F) HACER REACCIONAR (VIII) CON (IX) PARA DAR (I). EN LAS FORMULAS X=N,O,S; R1=H,CH3; R2=H,CH3,C2H5,C3H7; Y R3=H,CH3). LOS COMPUESTOS DE FORMULA (I) TIENEN APLICACION COMO POTENTES AGENTES ANTIBACTERIANOS, ACTIVOS FRENTE A GERMENES GRAM NEGATIVOS, EN ESPECIAL, Y FRENTE A ALGUNOS GERMENES GRAM POSITIVOS.
ES9202059A 1992-10-16 1992-10-16 Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico. Expired - Lifetime ES2050613B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202059A ES2050613B1 (es) 1992-10-16 1992-10-16 Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202059A ES2050613B1 (es) 1992-10-16 1992-10-16 Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.

Publications (2)

Publication Number Publication Date
ES2050613A1 true ES2050613A1 (es) 1994-05-16
ES2050613B1 ES2050613B1 (es) 1996-03-16

Family

ID=8278449

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202059A Expired - Lifetime ES2050613B1 (es) 1992-10-16 1992-10-16 Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.

Country Status (1)

Country Link
ES (1) ES2050613B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110122493A (zh) * 2019-06-14 2019-08-16 山东省联合农药工业有限公司 喹诺酮类化合物用于防治有用植物中细菌性有害生物的用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8307787A1 (es) * 1981-10-29 1983-07-16 Bayer Ag Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos.
EP0274033A1 (de) * 1986-12-03 1988-07-13 Bayer Ag Verfahren zur Herstellung von Chinolincarbonsäuren
EP0332033A2 (de) * 1988-03-11 1989-09-13 Bayer Ag N-Cyclopropylaniline und deren Verwendung in Verfahren zur Herstellung von 1-Cyclopropyl-chinoloncarbonsäuren und deren Derivaten
EP0343574A1 (en) * 1988-05-24 1989-11-29 Kirin Beer Kabushiki Kaisha 4(1H)-quinolone derivatives
ES2010948A6 (es) * 1989-04-27 1989-12-01 Cenavisa S A Un procedimiento para la preparacion de derivados del acido 3-quinolincarboxilico.
EP0348088A1 (en) * 1988-06-21 1989-12-27 Pfizer Inc. 6-Fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8307787A1 (es) * 1981-10-29 1983-07-16 Bayer Ag Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos.
EP0274033A1 (de) * 1986-12-03 1988-07-13 Bayer Ag Verfahren zur Herstellung von Chinolincarbonsäuren
EP0332033A2 (de) * 1988-03-11 1989-09-13 Bayer Ag N-Cyclopropylaniline und deren Verwendung in Verfahren zur Herstellung von 1-Cyclopropyl-chinoloncarbonsäuren und deren Derivaten
EP0343574A1 (en) * 1988-05-24 1989-11-29 Kirin Beer Kabushiki Kaisha 4(1H)-quinolone derivatives
EP0348088A1 (en) * 1988-06-21 1989-12-27 Pfizer Inc. 6-Fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
ES2010948A6 (es) * 1989-04-27 1989-12-01 Cenavisa S A Un procedimiento para la preparacion de derivados del acido 3-quinolincarboxilico.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110122493A (zh) * 2019-06-14 2019-08-16 山东省联合农药工业有限公司 喹诺酮类化合物用于防治有用植物中细菌性有害生物的用途

Also Published As

Publication number Publication date
ES2050613B1 (es) 1996-03-16

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