ES2043557A1 - Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina. - Google Patents

Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina.

Info

Publication number
ES2043557A1
ES2043557A1 ES9201158A ES9201158A ES2043557A1 ES 2043557 A1 ES2043557 A1 ES 2043557A1 ES 9201158 A ES9201158 A ES 9201158A ES 9201158 A ES9201158 A ES 9201158A ES 2043557 A1 ES2043557 A1 ES 2043557A1
Authority
ES
Spain
Prior art keywords
general formula
end products
derivatives
obtaining new
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9201158A
Other languages
English (en)
Other versions
ES2043557B1 (es
Inventor
Ambros Rafael Foguet
Gener Jordi Bolos
Hernandez Jose A Ortiz
Munoz Aurelio Sacristan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Priority to ES9201158A priority Critical patent/ES2043557B1/es
Priority to ES09300928A priority patent/ES2060547B1/es
Priority to CA002096611A priority patent/CA2096611C/en
Priority to ZA933681A priority patent/ZA933681B/xx
Priority to PH46253A priority patent/PH30422A/en
Priority to EP93108693A priority patent/EP0572952A1/en
Priority to JP5133582A priority patent/JP2610384B2/ja
Priority to KR1019930010133A priority patent/KR0128229B1/ko
Priority to US08/071,265 priority patent/US5395841A/en
Publication of ES2043557A1 publication Critical patent/ES2043557A1/es
Application granted granted Critical
Publication of ES2043557B1 publication Critical patent/ES2043557B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PROCEDIMIENTO DE OBTENCION DE NUEVOS DERIVADOS DE LA 4-BENCILPIPERIDINA. CONSISTE EN LA ALQUILACION DE LAS 4-BENCILPIPERIDINAS (II) CON LOS 3-HALOPROPIL-DERIVADOS DE FORMULA GENERAL (IV), DONDE Y ES HALOGENO Y R ES HIDROGENO, P-FLUOROFENOXI, BIS(P-FLUOROFENIL)-METIL O 8-AZAESPIRO-4,5-DECANO-7,9-DIONA-8-IL-METIL, O BIEN CON 2-(3-CLOROPROPIL)-2-(P-FLUOROFENIL)-1,3-DIOXOLANO (V), OBTENIENDOSE ASI LOS PRODUCTOS FINALES (I) DONDE R TIENE IGUAL SIGNIFICADO QUE EN (IV), O BIEN LOS ETILEN CETALES INTERMEDIOS DE FORMULA GENERAL (III). ESTOS ULTIMOS SE HIDROLIZAN A LOS PRODUCTOS FINALES (I) DONDE R ES P-FLUOROBENZOIL, PUDIENDOSE REDUCIR A SU VEZ A LOS OTROS PRODUCTOS FINALES (I) DONDE R ES HIDROXI-P-FLUOROBENCIL. EN TODO EL ESQUEMA, X SIGNIFICA HIDROGENO O FLUOR. LOS COMPUESTOS DE FORMULA GENERAL (I) TIENEN APLICACION FARMACOLOGICA POR SU ACTIVIDAD SOBRE EL SISTEMA NERVIOSO CENTRAL. **FORMULA**
ES9201158A 1992-06-04 1992-06-04 Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina. Expired - Fee Related ES2043557B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES9201158A ES2043557B1 (es) 1992-06-04 1992-06-04 Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina.
ES09300928A ES2060547B1 (es) 1992-06-04 1993-05-03 Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
CA002096611A CA2096611C (en) 1992-06-04 1993-05-19 4-benzylpiperidine derivatives and process for their production
ZA933681A ZA933681B (en) 1992-06-04 1993-05-26 4-Benzylpiperidine derivatives and process for their production
PH46253A PH30422A (en) 1992-06-04 1993-05-27 4-Benzylpiperidines for treating psychosis
EP93108693A EP0572952A1 (en) 1992-06-04 1993-05-28 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them
JP5133582A JP2610384B2 (ja) 1992-06-04 1993-06-03 ４−ベンジルピペリジン誘導体、その製造法及び該誘導体を含んで成る製剤組成物
KR1019930010133A KR0128229B1 (ko) 1992-06-04 1993-06-04 4-벤질피페리딘 유도체 및 이의 약제학적으로 허용하는 염, 및 이들의 제조방법
US08/071,265 US5395841A (en) 1992-06-04 1993-06-04 4-benzylpiperidines for treating phychosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201158A ES2043557B1 (es) 1992-06-04 1992-06-04 Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina.

Publications (2)

Publication Number Publication Date
ES2043557A1 true ES2043557A1 (es) 1993-12-16
ES2043557B1 ES2043557B1 (es) 1994-07-01

Family

ID=8277220

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9201158A Expired - Fee Related ES2043557B1 (es) 1992-06-04 1992-06-04 Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina.

Country Status (2)

Country Link
ES (1) ES2043557B1 (es)
ZA (1) ZA933681B (es)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077427A1 (fr) * 1981-10-15 1983-04-27 Synthelabo Dérivés de pipéridine, leur procédé de préparation et leur application en thérapeutique
EP0229391A1 (en) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Piperidine derivate, its use and pharmaceutical composition containing it
EP0288563A1 (en) * 1986-09-30 1988-11-02 Eisai Co., Ltd. Cyclic amine derivatives
EP0428434A2 (fr) * 1989-11-06 1991-05-22 Sanofi Composés aromatiques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077427A1 (fr) * 1981-10-15 1983-04-27 Synthelabo Dérivés de pipéridine, leur procédé de préparation et leur application en thérapeutique
EP0229391A1 (en) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Piperidine derivate, its use and pharmaceutical composition containing it
EP0288563A1 (en) * 1986-09-30 1988-11-02 Eisai Co., Ltd. Cyclic amine derivatives
EP0428434A2 (fr) * 1989-11-06 1991-05-22 Sanofi Composés aromatiques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ES2043557B1 (es) 1994-07-01
ZA933681B (en) 1994-02-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100528