ES2040281T3 - Derivados mono- y di-epoxido de composiciones delta 22-ll-f28249. - Google Patents
Derivados mono- y di-epoxido de composiciones delta 22-ll-f28249.Info
- Publication number
- ES2040281T3 ES2040281T3 ES198888101846T ES88101846T ES2040281T3 ES 2040281 T3 ES2040281 T3 ES 2040281T3 ES 198888101846 T ES198888101846 T ES 198888101846T ES 88101846 T ES88101846 T ES 88101846T ES 2040281 T3 ES2040281 T3 ES 2040281T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- hydroxyl group
- double bond
- delta
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dentistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Environmental Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE COMPUESTOS LL-F28249 EN LOS QUE EL GRUPO HIDROXILO EN 23 SE ELIMINA PARA FORMAR UN DOBLE ENLACE EN LA POSICION -C(22,23)(A 22) Y EL DOBLE ENLACE DE LA POSICION C(26,27) ES EPOXIDADO CONCOMITANTEMENTE CON O SIN EPOXIDACION DEL DOBLE ENLACE DE LA POSICION -C(14,15). ESTOS COMPUESTOS LL-F28249 (COLECTIVAMENTE) SE AISLAN DEL CALDO DE FERMENTACION DE STREPTOMYCES CYANOGRISEUS SUBESPECIES NONCYANOGENUS QUE TIENE UN NUMERO DE ACCESION DE DEPOSITO NRRL 15773.LOS COMPUESTOS DE LA PRESENTE INVENCION SE DERIVAN POR EPOXIDACION REGIOSELECTIVA DE COMPUESTOS LL-F28249, 5, 23, O, O-BISILILADOS A TEMPERATURA BAJA, DESILILACION, RE-SILILACION DEL GRUPO 5-HIDROXILO, TIOCARBONILACION DEL GRUPO HIDROXILO EN 23, DESILILACION Y TERMALIZACION. LOS NUEVOS COMPUESTOS TIENEN ACTIVIDAD ANTIHELMINTICA, INSECTICIDA, ECTOPARASITICIDA, NEMATICIDA Y ACARICIDA. SE INCLUYEN COMPOSICIONES QUE CONTIENEN ESTOS DERIVADOS COMO INGREDIENTES ACTIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/022,846 US4851428A (en) | 1987-03-06 | 1987-03-06 | Mono- and diepoxide derivatives of Δ22-LL-F28249 compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2040281T3 true ES2040281T3 (es) | 1993-10-16 |
Family
ID=21811728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198888101846T Expired - Lifetime ES2040281T3 (es) | 1987-03-06 | 1988-02-09 | Derivados mono- y di-epoxido de composiciones delta 22-ll-f28249. |
Country Status (17)
Country | Link |
---|---|
US (1) | US4851428A (es) |
EP (1) | EP0280927B1 (es) |
JP (1) | JP2583947B2 (es) |
KR (1) | KR960006387B1 (es) |
AT (1) | ATE77090T1 (es) |
AU (1) | AU607191B2 (es) |
BR (1) | BR8800940A (es) |
CA (1) | CA1291129C (es) |
DE (1) | DE3871819T2 (es) |
DK (1) | DK119788A (es) |
ES (1) | ES2040281T3 (es) |
GR (1) | GR3004862T3 (es) |
HU (1) | HU202534B (es) |
IE (1) | IE63946B1 (es) |
NZ (1) | NZ223644A (es) |
PT (1) | PT86901B (es) |
ZA (1) | ZA881578B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106994A (en) * | 1984-06-05 | 1992-04-21 | American Cyanamid Company | Agents and method of production thereof |
US5053414A (en) * | 1988-04-08 | 1991-10-01 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
JP2654337B2 (ja) * | 1992-09-01 | 1997-09-17 | 三共株式会社 | 13−エーテル置換ミルベマイシン誘導体の新規中間体 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4530921A (en) * | 1983-10-03 | 1985-07-23 | Merck & Co., Inc. | Avermectin epoxide derivatives and method of use |
DK614084A (da) * | 1983-12-30 | 1985-07-01 | Ciba Geigy Ag | Milbemycim-derivater samt deres fremstilling og anvendelse |
DK165119C (da) * | 1984-06-05 | 1993-03-01 | American Cyanamid Co | Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling |
CS268803B2 (en) * | 1984-09-14 | 1990-04-11 | Glaxo Group Ltd | Pesticide |
ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
US4886829A (en) * | 1987-03-06 | 1989-12-12 | American Cyanamid Company | 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds |
US4876272A (en) * | 1987-03-06 | 1989-10-24 | American Cyanamid Company | Mono- and diepoxide derivatives of LL-F28249 compounds |
-
1987
- 1987-03-06 US US07/022,846 patent/US4851428A/en not_active Expired - Lifetime
-
1988
- 1988-02-09 EP EP88101846A patent/EP0280927B1/en not_active Expired - Lifetime
- 1988-02-09 AT AT88101846T patent/ATE77090T1/de not_active IP Right Cessation
- 1988-02-09 DE DE8888101846T patent/DE3871819T2/de not_active Expired - Lifetime
- 1988-02-09 ES ES198888101846T patent/ES2040281T3/es not_active Expired - Lifetime
- 1988-02-25 NZ NZ223644A patent/NZ223644A/xx unknown
- 1988-03-04 IE IE62288A patent/IE63946B1/en not_active IP Right Cessation
- 1988-03-04 HU HU881074A patent/HU202534B/hu unknown
- 1988-03-04 DK DK119788A patent/DK119788A/da not_active Application Discontinuation
- 1988-03-04 BR BR8800940A patent/BR8800940A/pt not_active IP Right Cessation
- 1988-03-04 JP JP63049895A patent/JP2583947B2/ja not_active Expired - Fee Related
- 1988-03-04 ZA ZA881578A patent/ZA881578B/xx unknown
- 1988-03-04 PT PT86901A patent/PT86901B/pt not_active IP Right Cessation
- 1988-03-04 CA CA000560567A patent/CA1291129C/en not_active Expired - Lifetime
- 1988-03-04 AU AU12717/88A patent/AU607191B2/en not_active Expired
- 1988-03-05 KR KR1019880002326A patent/KR960006387B1/ko not_active IP Right Cessation
-
1992
- 1992-06-11 GR GR920400077T patent/GR3004862T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR960006387B1 (ko) | 1996-05-15 |
PT86901A (pt) | 1988-04-01 |
CA1291129C (en) | 1991-10-22 |
ZA881578B (en) | 1988-08-29 |
BR8800940A (pt) | 1988-10-11 |
EP0280927B1 (en) | 1992-06-10 |
JP2583947B2 (ja) | 1997-02-19 |
HU202534B (en) | 1991-03-28 |
DK119788A (da) | 1988-09-07 |
PT86901B (pt) | 1992-05-29 |
DE3871819D1 (de) | 1992-07-16 |
JPS63270686A (ja) | 1988-11-08 |
IE63946B1 (en) | 1995-06-28 |
KR880011165A (ko) | 1988-10-27 |
US4851428A (en) | 1989-07-25 |
DE3871819T2 (de) | 1992-12-10 |
AU607191B2 (en) | 1991-02-28 |
NZ223644A (en) | 1991-01-29 |
AU1271788A (en) | 1988-09-08 |
GR3004862T3 (es) | 1993-04-28 |
ATE77090T1 (de) | 1992-06-15 |
DK119788D0 (da) | 1988-03-04 |
HUT46016A (en) | 1988-09-28 |
IE880622L (en) | 1988-09-06 |
EP0280927A1 (en) | 1988-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE872438L (en) | 23-oxo(keto) and 23-imino derivatives of ll-f28249 compounds | |
ES8400144A1 (es) | Un procedimiento para la preparacion de macrolidas c-076 | |
ES2068178T3 (es) | Nuevos derivados 23-imino de compuesto 23-ceto. | |
ES2040281T3 (es) | Derivados mono- y di-epoxido de composiciones delta 22-ll-f28249. | |
IE872440L (en) | 13-deoxy-23-oxo (keto) and 23-imino derivatives of 13-deoxy¹c-076-aglycone compounds | |
DE3787942D1 (de) | Mono- und Diacylderivate von LL-F28249-Verbindungen. | |
IE880621L (en) | Mono- and diepoxide derivatives of 23-deoxy-LL-F28249¹compounds | |
EP0297205A3 (en) | 27-halo derivatives of ll-f28249 compounds | |
NZ221693A (en) | Delta-23-milbemycin derivatives and parasiticidal compositions | |
NZ228280A (en) | Milbemycin derivatives and insecticidal and parasiticidal compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 280927 Country of ref document: ES |