ES2039299B1 - PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS. - Google Patents

PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Info

Publication number
ES2039299B1
ES2039299B1 ES9102196A ES9102196A ES2039299B1 ES 2039299 B1 ES2039299 B1 ES 2039299B1 ES 9102196 A ES9102196 A ES 9102196A ES 9102196 A ES9102196 A ES 9102196A ES 2039299 B1 ES2039299 B1 ES 2039299B1
Authority
ES
Spain
Prior art keywords
group
procedure
acid
axyl
halogen atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9102196A
Other languages
Spanish (es)
Other versions
ES2039299A1 (en
Inventor
Pinilla Paloma Esteban
Jose Fernandez-Simon
Pablo Bernard
Martin Juan Antonio Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES9102196A priority Critical patent/ES2039299B1/en
Publication of ES2039299A1 publication Critical patent/ES2039299A1/en
Application granted granted Critical
Publication of ES2039299B1 publication Critical patent/ES2039299B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DEL ACIDO 1, 1-DROXOPENICILANICO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES DE FORMULA I (ESQUEMA I), DONDE R REPRESENTA UN ANILLO AROMATICO O HETEROAROMATICO, SUSTITUIDO O NO POR GRUPOS ALQUILO INFERIOR, HIDROXILO, ALCOXILO INFERIOR, CARBOXILO Y/O ARILO, SUSTITUIDO O NO, A SU VEZ, POR ATOMOS DE HALOGENO, O UN RESTO DEL TIPO R1R2CH-, DONDE R1 REPRESENTA UN ATOMO DE HIDROGENO, UN RESTO ALQUILO INFERIOR O UN GRUPO ARILO O HETEROARILO SUSTITUIDO O NO POR RESTOS HIDROXILO O ATOMOS DE HALOGENO, Y R2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALCOXILO INFERIOR, ARILOXI, AMINO, CARBOXILO O UN GRUPO DEL TIPO -COOR3 DONDE R3 REPRESENTA UN GRUPO FENILO O CICLOPENTAFENILO. SE OBTIENE HACIENDO REACCIONAR EL COMPUESTO II, DONDE X REPRESENTA UN ATOMO BROMO CON METAL REDUCTOR EN POLVO EN MEDIO ACUOSO/ORGANICO. SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS.PROCEDURE FOR THE OBTAINING OF ESTERS OF ACID 1, 1-DROXOPENICILANICO AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS OF FORMULA I (SCHEME I), WHERE R REPRESENTS AN AROMATIC RING, AEROILYAL, AXYL, AND AXYL, / OR ARIL, SUBSTITUTED OR NOT, IN turn, BY HALOGEN ATOMS, OR A REST OF TYPE R1R2CH-, WHERE R1 REPRESENTS A HYDROGEN ATOM, A REST LOWER ALKYL OR A ARILO OR HETEROARYL GROUP SUBSTITUTED OR NOT BY ROSE HERO HALOGEN ATOMS, AND R2 REPRESENTS A HYDROGEN ATOM OR A LOWER ALCOXYL GROUP, ARILOXI, AMINO, CARBOXYL, OR A -COOR3-TYPE GROUP WHERE R3 REPRESENTS A PHENYL OR CYCLOPENTHENYL GROUP. IT IS OBTAINED BY REACTIONING COMPOUND II, WHERE X REPRESENTS A BROMINE ATOM WITH REDUCING METAL POWDER IN AQUEOUS / ORGANIC MEDIUM. THEY ARE USEFUL IN THE TREATMENT OF BACTERIAL INFECTIONS.

ES9102196A 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS. Expired - Fee Related ES2039299B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9102196A ES2039299B1 (en) 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102196A ES2039299B1 (en) 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Publications (2)

Publication Number Publication Date
ES2039299A1 ES2039299A1 (en) 1993-09-16
ES2039299B1 true ES2039299B1 (en) 1994-05-16

Family

ID=8273730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102196A Expired - Fee Related ES2039299B1 (en) 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Country Status (1)

Country Link
ES (1) ES2039299B1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2100125B1 (en) * 1995-06-02 1998-04-01 Asturpharma S A PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.
EP1149107A4 (en) * 1998-12-08 2002-04-17 Lilly Co Eli Process of preparing esters of penicillanic acid sulfoxide
ES2237064T3 (en) * 1999-03-03 2005-07-16 Astur Pharma S.A. PROCEDURE TO PREPARE DERIVATIVES OF DIOXOPENICILANIC ACID.
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
IN159362B (en) * 1981-03-23 1987-05-09 Pfizer
PT76526B (en) * 1982-04-19 1986-01-21 Gist Brocades Nv Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides
PH20068A (en) * 1982-12-06 1986-09-18 Pfizer Process and intermediates for sultamicillin and analogs

Also Published As

Publication number Publication date
ES2039299A1 (en) 1993-09-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041005