ES2039299A1 - Process for obtaining 1,1-dioxopenicillanic acid esters and their salts - Google Patents
Process for obtaining 1,1-dioxopenicillanic acid esters and their saltsInfo
- Publication number
- ES2039299A1 ES2039299A1 ES9102196A ES9102196A ES2039299A1 ES 2039299 A1 ES2039299 A1 ES 2039299A1 ES 9102196 A ES9102196 A ES 9102196A ES 9102196 A ES9102196 A ES 9102196A ES 2039299 A1 ES2039299 A1 ES 2039299A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- substituted
- obtaining
- halogen atoms
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Process for obtaining esters of 1,1-dioxopenicillanic acid and their pharmaceutically acceptable salts of formula 1 < IMAGE > in which R represents an aromatic or heteroaromatic ring, which may or may not be substituted by lower alkyl, hydroxyl, lower alkoxyl, carboxyl and/or aryl groups which in turn may or may not be substituted by halogen atoms or a lower alkyl residue or an aryl or heteroaryl group which may or may not be substituted by hydroxyl residues or halogen atoms, and R2 represents a hydrogen atom or a lower alkoxyl, aryloxy, amine, carboxyl group or group of the type -COOR3 where R3 represents a phenyl or cyclopentophenyl group. They are obtained by reacting compound II, where X represents a bromine atom, with a reducing metal in powder form in aqueous/organic medium. They are useful in the treatment of bacterial infections.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9102196A ES2039299B1 (en) | 1991-10-04 | 1991-10-04 | PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9102196A ES2039299B1 (en) | 1991-10-04 | 1991-10-04 | PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2039299A1 true ES2039299A1 (en) | 1993-09-16 |
ES2039299B1 ES2039299B1 (en) | 1994-05-16 |
Family
ID=8273730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9102196A Expired - Fee Related ES2039299B1 (en) | 1991-10-04 | 1991-10-04 | PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2039299B1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2100125A1 (en) * | 1995-06-02 | 1997-06-01 | Asturpharma S A | Process for the preparation of methanediol esters of dioxopenicillanic acid |
WO2000034289A1 (en) * | 1998-12-08 | 2000-06-15 | Eli Lilly And Company | Process of preparing esters of penicillanic acid sulfoxide |
EP1041075A1 (en) * | 1999-03-03 | 2000-10-04 | Alex-Gyogyszer Kutatási | Procedure for the preparation of dioxopenicillanic acid derivatives |
WO2007004239A1 (en) * | 2005-07-06 | 2007-01-11 | Morepen Laboratories Limited | New polymorphic form of sultamicillin tosylate and a process therefor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8305767A1 (en) * | 1981-03-23 | 1983-04-16 | Pfizer | Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein. |
ES8403132A1 (en) * | 1981-03-23 | 1984-03-01 | Pfizer | Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates. |
ES8405019A1 (en) * | 1982-04-19 | 1984-05-16 | Gist Brocades Nv | Preparation of 6-alpha-bromo- and/or 6,6-dibromo-penicillanic acid 1,1-dioxides. |
ES8504824A1 (en) * | 1982-12-06 | 1985-05-01 | Pfizer | Process and intermediates for sultamicillin and analogs. |
-
1991
- 1991-10-04 ES ES9102196A patent/ES2039299B1/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8305767A1 (en) * | 1981-03-23 | 1983-04-16 | Pfizer | Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein. |
ES8403132A1 (en) * | 1981-03-23 | 1984-03-01 | Pfizer | Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates. |
ES8405019A1 (en) * | 1982-04-19 | 1984-05-16 | Gist Brocades Nv | Preparation of 6-alpha-bromo- and/or 6,6-dibromo-penicillanic acid 1,1-dioxides. |
ES8504824A1 (en) * | 1982-12-06 | 1985-05-01 | Pfizer | Process and intermediates for sultamicillin and analogs. |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2100125A1 (en) * | 1995-06-02 | 1997-06-01 | Asturpharma S A | Process for the preparation of methanediol esters of dioxopenicillanic acid |
WO2000034289A1 (en) * | 1998-12-08 | 2000-06-15 | Eli Lilly And Company | Process of preparing esters of penicillanic acid sulfoxide |
EP1041075A1 (en) * | 1999-03-03 | 2000-10-04 | Alex-Gyogyszer Kutatási | Procedure for the preparation of dioxopenicillanic acid derivatives |
WO2007004239A1 (en) * | 2005-07-06 | 2007-01-11 | Morepen Laboratories Limited | New polymorphic form of sultamicillin tosylate and a process therefor |
Also Published As
Publication number | Publication date |
---|---|
ES2039299B1 (en) | 1994-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041005 |