ES2039299A1 - Process for obtaining 1,1-dioxopenicillanic acid esters and their salts - Google Patents

Process for obtaining 1,1-dioxopenicillanic acid esters and their salts

Info

Publication number
ES2039299A1
ES2039299A1 ES9102196A ES9102196A ES2039299A1 ES 2039299 A1 ES2039299 A1 ES 2039299A1 ES 9102196 A ES9102196 A ES 9102196A ES 9102196 A ES9102196 A ES 9102196A ES 2039299 A1 ES2039299 A1 ES 2039299A1
Authority
ES
Spain
Prior art keywords
group
substituted
obtaining
halogen atoms
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9102196A
Other languages
Spanish (es)
Other versions
ES2039299B1 (en
Inventor
Pinilla Paloma Esteban
Jose Fernandez-Simon
Pablo Bernard
Martin Juan Antonio Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES9102196A priority Critical patent/ES2039299B1/en
Publication of ES2039299A1 publication Critical patent/ES2039299A1/en
Application granted granted Critical
Publication of ES2039299B1 publication Critical patent/ES2039299B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Process for obtaining esters of 1,1-dioxopenicillanic acid and their pharmaceutically acceptable salts of formula 1 < IMAGE > in which R represents an aromatic or heteroaromatic ring, which may or may not be substituted by lower alkyl, hydroxyl, lower alkoxyl, carboxyl and/or aryl groups which in turn may or may not be substituted by halogen atoms or a lower alkyl residue or an aryl or heteroaryl group which may or may not be substituted by hydroxyl residues or halogen atoms, and R2 represents a hydrogen atom or a lower alkoxyl, aryloxy, amine, carboxyl group or group of the type -COOR3 where R3 represents a phenyl or cyclopentophenyl group. They are obtained by reacting compound II, where X represents a bromine atom, with a reducing metal in powder form in aqueous/organic medium. They are useful in the treatment of bacterial infections.
ES9102196A 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS. Expired - Fee Related ES2039299B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9102196A ES2039299B1 (en) 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102196A ES2039299B1 (en) 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Publications (2)

Publication Number Publication Date
ES2039299A1 true ES2039299A1 (en) 1993-09-16
ES2039299B1 ES2039299B1 (en) 1994-05-16

Family

ID=8273730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102196A Expired - Fee Related ES2039299B1 (en) 1991-10-04 1991-10-04 PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Country Status (1)

Country Link
ES (1) ES2039299B1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2100125A1 (en) * 1995-06-02 1997-06-01 Asturpharma S A Process for the preparation of methanediol esters of dioxopenicillanic acid
WO2000034289A1 (en) * 1998-12-08 2000-06-15 Eli Lilly And Company Process of preparing esters of penicillanic acid sulfoxide
EP1041075A1 (en) * 1999-03-03 2000-10-04 Alex-Gyogyszer Kutatási Procedure for the preparation of dioxopenicillanic acid derivatives
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8305767A1 (en) * 1981-03-23 1983-04-16 Pfizer Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein.
ES8403132A1 (en) * 1981-03-23 1984-03-01 Pfizer Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates.
ES8405019A1 (en) * 1982-04-19 1984-05-16 Gist Brocades Nv Preparation of 6-alpha-bromo- and/or 6,6-dibromo-penicillanic acid 1,1-dioxides.
ES8504824A1 (en) * 1982-12-06 1985-05-01 Pfizer Process and intermediates for sultamicillin and analogs.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8305767A1 (en) * 1981-03-23 1983-04-16 Pfizer Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein.
ES8403132A1 (en) * 1981-03-23 1984-03-01 Pfizer Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates.
ES8405019A1 (en) * 1982-04-19 1984-05-16 Gist Brocades Nv Preparation of 6-alpha-bromo- and/or 6,6-dibromo-penicillanic acid 1,1-dioxides.
ES8504824A1 (en) * 1982-12-06 1985-05-01 Pfizer Process and intermediates for sultamicillin and analogs.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2100125A1 (en) * 1995-06-02 1997-06-01 Asturpharma S A Process for the preparation of methanediol esters of dioxopenicillanic acid
WO2000034289A1 (en) * 1998-12-08 2000-06-15 Eli Lilly And Company Process of preparing esters of penicillanic acid sulfoxide
EP1041075A1 (en) * 1999-03-03 2000-10-04 Alex-Gyogyszer Kutatási Procedure for the preparation of dioxopenicillanic acid derivatives
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor

Also Published As

Publication number Publication date
ES2039299B1 (en) 1994-05-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041005