ES2100125B1 - PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. - Google Patents

PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.

Info

Publication number
ES2100125B1
ES2100125B1 ES9501106A ES9501106A ES2100125B1 ES 2100125 B1 ES2100125 B1 ES 2100125B1 ES 9501106 A ES9501106 A ES 9501106A ES 9501106 A ES9501106 A ES 9501106A ES 2100125 B1 ES2100125 B1 ES 2100125B1
Authority
ES
Spain
Prior art keywords
methanodiol
dioxopenicilanic
esters
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9501106A
Other languages
Spanish (es)
Other versions
ES2100125A1 (en
Inventor
Pinilla Paloma Esteban
Simon Jose Fernandez
Martin Juan Antonio Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES9501106A priority Critical patent/ES2100125B1/en
Publication of ES2100125A1 publication Critical patent/ES2100125A1/en
Application granted granted Critical
Publication of ES2100125B1 publication Critical patent/ES2100125B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE ESTERES DE METANODIOL DE ACIDO DIOXOPENICILANICO. (57) PROCEDIMIENTO PARA LA PREPARACION DE ESTERES DE METANODIOL DEL ACIDO 1,1-DIOXOPENICILANICO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES DE FORMULA I (ESQUEMA I), DONDE R1 REPRESENTA UN ATOMO DE HIDROGENO, RESTO ALQUILO INFERIOR, O BIEN, CONSTITUYE CON R2 UN ANILLO DE 5 O 6 CARBONOS, R2 REPRESENTA UN ATOMO DE HIDROGENO, UN RESTO ALQUILO INFERIOR, CICLOALQUENILO, O ARILO, SUSTITUIDO O NO POR RESTOS HIDROXILO O ALCOXILO INFERIOR, Y R3 REPRESENTA UN GRUPO AMINO LIBRE. SE OBTIENEN POR HIDROGENACION EN PRESENCIA DE UN CATALIZADOR DE METAL NOBLE DEL COMPUESTO II, DONDE R1 Y R2 TIENEN EL SIGNIFICADO ANTERIOR, R3 REPRESENTA UN GRUPO AMINO LIBRE O PROTEGIDO Y R4 REPRESENTA UN ATOMO DE BROMO. SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS. COMBINAN UN ANTIBIOTICO BETALACTAMICO CON UN INHIBIDOR DE BETALACTAMASAS EN UNA UNICA MOLECULA.PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. (57) PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS OF FORMULA I (SCHEME I), WHERE R1 REPRESENTS AN ATOME OF HYDROGEN, REMAIN ALKYL, OR RING OF 5 OR 6 CARBONS, R2 REPRESENTS A HYDROGEN ATOM, A REST LOWER ALKYL, CYCLOALKENYL, OR ARYL, REPLACED OR NOT BY LOWER HYDROXYL OR ALCOXYL, AND R3 REPRESENTS A FREE AMINO GROUP. THEY ARE OBTAINED BY HYDROGENATION IN THE PRESENCE OF A NOBLE METAL CATALYST OF COMPOUND II, WHERE R1 AND R2 HAVE THE PREVIOUS MEANING, R3 REPRESENTS A FREE OR PROTECTED AMINO GROUP AND R4 REPRESENTS A SPRAY ATOM. THEY ARE USEFUL IN THE TREATMENT OF BACTERIAL INFECTIONS. COMBINE A BETALACTAMIC ANTIBIOTIC WITH A BETALACTAMASE INHIBITOR IN A SINGLE MOLECULA.

ES9501106A 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. Expired - Fee Related ES2100125B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9501106A ES2100125B1 (en) 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501106A ES2100125B1 (en) 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.

Publications (2)

Publication Number Publication Date
ES2100125A1 ES2100125A1 (en) 1997-06-01
ES2100125B1 true ES2100125B1 (en) 1998-04-01

Family

ID=8290613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501106A Expired - Fee Related ES2100125B1 (en) 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.

Country Status (1)

Country Link
ES (1) ES2100125B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2161602B1 (en) * 1999-04-08 2003-02-16 Asturpharma S A SYNTHESIS OF 6- (D-ALPHA- (BENCILIDENAMINOPHENYLACETAMIDE)) PENICILANATE 1,1-DIOXOPENICILANLANILOXIMETILO AND ANALOGS. NEW INTERMEDIATES FOR SYNTHESIS OF SULTAMICILLIN.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
IN159362B (en) * 1981-03-23 1987-05-09 Pfizer
PH20068A (en) * 1982-12-06 1986-09-18 Pfizer Process and intermediates for sultamicillin and analogs
ES2039299B1 (en) * 1991-10-04 1994-05-16 Asturpharma S A PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS.

Also Published As

Publication number Publication date
ES2100125A1 (en) 1997-06-01

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