ES2100125B1 - PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. - Google Patents
PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.Info
- Publication number
- ES2100125B1 ES2100125B1 ES9501106A ES9501106A ES2100125B1 ES 2100125 B1 ES2100125 B1 ES 2100125B1 ES 9501106 A ES9501106 A ES 9501106A ES 9501106 A ES9501106 A ES 9501106A ES 2100125 B1 ES2100125 B1 ES 2100125B1
- Authority
- ES
- Spain
- Prior art keywords
- methanodiol
- dioxopenicilanic
- esters
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE ESTERES DE METANODIOL DE ACIDO DIOXOPENICILANICO. (57) PROCEDIMIENTO PARA LA PREPARACION DE ESTERES DE METANODIOL DEL ACIDO 1,1-DIOXOPENICILANICO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES DE FORMULA I (ESQUEMA I), DONDE R1 REPRESENTA UN ATOMO DE HIDROGENO, RESTO ALQUILO INFERIOR, O BIEN, CONSTITUYE CON R2 UN ANILLO DE 5 O 6 CARBONOS, R2 REPRESENTA UN ATOMO DE HIDROGENO, UN RESTO ALQUILO INFERIOR, CICLOALQUENILO, O ARILO, SUSTITUIDO O NO POR RESTOS HIDROXILO O ALCOXILO INFERIOR, Y R3 REPRESENTA UN GRUPO AMINO LIBRE. SE OBTIENEN POR HIDROGENACION EN PRESENCIA DE UN CATALIZADOR DE METAL NOBLE DEL COMPUESTO II, DONDE R1 Y R2 TIENEN EL SIGNIFICADO ANTERIOR, R3 REPRESENTA UN GRUPO AMINO LIBRE O PROTEGIDO Y R4 REPRESENTA UN ATOMO DE BROMO. SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS. COMBINAN UN ANTIBIOTICO BETALACTAMICO CON UN INHIBIDOR DE BETALACTAMASAS EN UNA UNICA MOLECULA.PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. (57) PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS OF FORMULA I (SCHEME I), WHERE R1 REPRESENTS AN ATOME OF HYDROGEN, REMAIN ALKYL, OR RING OF 5 OR 6 CARBONS, R2 REPRESENTS A HYDROGEN ATOM, A REST LOWER ALKYL, CYCLOALKENYL, OR ARYL, REPLACED OR NOT BY LOWER HYDROXYL OR ALCOXYL, AND R3 REPRESENTS A FREE AMINO GROUP. THEY ARE OBTAINED BY HYDROGENATION IN THE PRESENCE OF A NOBLE METAL CATALYST OF COMPOUND II, WHERE R1 AND R2 HAVE THE PREVIOUS MEANING, R3 REPRESENTS A FREE OR PROTECTED AMINO GROUP AND R4 REPRESENTS A SPRAY ATOM. THEY ARE USEFUL IN THE TREATMENT OF BACTERIAL INFECTIONS. COMBINE A BETALACTAMIC ANTIBIOTIC WITH A BETALACTAMASE INHIBITOR IN A SINGLE MOLECULA.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501106A ES2100125B1 (en) | 1995-06-02 | 1995-06-02 | PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501106A ES2100125B1 (en) | 1995-06-02 | 1995-06-02 | PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2100125A1 ES2100125A1 (en) | 1997-06-01 |
ES2100125B1 true ES2100125B1 (en) | 1998-04-01 |
Family
ID=8290613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9501106A Expired - Fee Related ES2100125B1 (en) | 1995-06-02 | 1995-06-02 | PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2100125B1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2161602B1 (en) * | 1999-04-08 | 2003-02-16 | Asturpharma S A | SYNTHESIS OF 6- (D-ALPHA- (BENCILIDENAMINOPHENYLACETAMIDE)) PENICILANATE 1,1-DIOXOPENICILANLANILOXIMETILO AND ANALOGS. NEW INTERMEDIATES FOR SYNTHESIS OF SULTAMICILLIN. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4419284A (en) * | 1981-03-23 | 1983-12-06 | Pfizer Inc. | Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide |
IN159362B (en) * | 1981-03-23 | 1987-05-09 | Pfizer | |
PH20068A (en) * | 1982-12-06 | 1986-09-18 | Pfizer | Process and intermediates for sultamicillin and analogs |
ES2039299B1 (en) * | 1991-10-04 | 1994-05-16 | Asturpharma S A | PROCEDURE FOR OBTAINING ESTERS OF 1,1-DIOXOPENICILANIC ACID AND ITS SALTS. |
-
1995
- 1995-06-02 ES ES9501106A patent/ES2100125B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2100125A1 (en) | 1997-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19970601 Kind code of ref document: A1 Effective date: 19970601 |
|
FD1A | Patent lapsed |
Effective date: 20050603 |