ES2038922A1 - Procedimiento para la obtencion de nizatidina. - Google Patents

Procedimiento para la obtencion de nizatidina.

Info

Publication number
ES2038922A1
ES2038922A1 ES919102899A ES9102899A ES2038922A1 ES 2038922 A1 ES2038922 A1 ES 2038922A1 ES 919102899 A ES919102899 A ES 919102899A ES 9102899 A ES9102899 A ES 9102899A ES 2038922 A1 ES2038922 A1 ES 2038922A1
Authority
ES
Spain
Prior art keywords
nizatidin
cpds
prepn
formula
isothiourea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES919102899A
Other languages
English (en)
Other versions
ES2038922B1 (es
Inventor
Gadea Jesus Santa-Olalla
Estrada Maria Tarancon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FERMENTACIONES Y SINTESIS ESPA
Original Assignee
FERMENTACIONES Y SINTESIS ESPA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FERMENTACIONES Y SINTESIS ESPA filed Critical FERMENTACIONES Y SINTESIS ESPA
Priority to ES9102899A priority Critical patent/ES2038922B1/es
Publication of ES2038922A1 publication Critical patent/ES2038922A1/es
Application granted granted Critical
Publication of ES2038922B1 publication Critical patent/ES2038922B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NIZATIDINA (I) POR REACCION ENTRE UNA ISOTIOUREA (II) Y UN AGENTE ALGUILANTE (III) DONDE X ES UN GRUPO SALIENTE, PREFERENTEMENTE CL O BR. EL PROCEDIMIENTO PUEDE REALIZARSE EN UN MEDIO ACUOSO O HIDROALCOHOLICO Y EN PRESENCIA DE UNA BASE QUE PUEDE SER ORGANICA O INORGANICA. LA NIZATIDINA ES UN BLOQUEANTE DE LOS RECEPTORES HSI2 SC DE HISTAMINA Y PUEDE SER UTILIZADA EN TERAPIA COMO AGENTE ANTIULCEROSO.
ES9102899A 1991-12-30 1991-12-30 Procedimiento para la obtencion de nizatidina. Expired - Fee Related ES2038922B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9102899A ES2038922B1 (es) 1991-12-30 1991-12-30 Procedimiento para la obtencion de nizatidina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102899A ES2038922B1 (es) 1991-12-30 1991-12-30 Procedimiento para la obtencion de nizatidina.

Publications (2)

Publication Number Publication Date
ES2038922A1 true ES2038922A1 (es) 1993-08-01
ES2038922B1 ES2038922B1 (es) 1994-04-16

Family

ID=8274637

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102899A Expired - Fee Related ES2038922B1 (es) 1991-12-30 1991-12-30 Procedimiento para la obtencion de nizatidina.

Country Status (1)

Country Link
ES (1) ES2038922B1 (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
EP0116452A2 (en) * 1983-02-07 1984-08-22 Eli Lilly And Company Improvements in or relating to the synthesis of nizatidine
EP0230127A1 (en) * 1985-12-18 1987-07-29 Eli Lilly And Company Synthesis of nizatidine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
EP0116452A2 (en) * 1983-02-07 1984-08-22 Eli Lilly And Company Improvements in or relating to the synthesis of nizatidine
EP0230127A1 (en) * 1985-12-18 1987-07-29 Eli Lilly And Company Synthesis of nizatidine

Also Published As

Publication number Publication date
ES2038922B1 (es) 1994-04-16

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Legal Events

Date Code Title Description
PC2A Transfer of patent
RD2A Seizure of patent freed

Effective date: 20010926

FD2A Announcement of lapse in spain

Effective date: 20180806