ES2038724T3 - Procedimiento para preparar derivados de 2-nitroimidazol utiles como radiosensibilizadores para celulas tumorales hipoxicas. - Google Patents
Procedimiento para preparar derivados de 2-nitroimidazol utiles como radiosensibilizadores para celulas tumorales hipoxicas.Info
- Publication number
- ES2038724T3 ES2038724T3 ES198888112377T ES88112377T ES2038724T3 ES 2038724 T3 ES2038724 T3 ES 2038724T3 ES 198888112377 T ES198888112377 T ES 198888112377T ES 88112377 T ES88112377 T ES 88112377T ES 2038724 T3 ES2038724 T3 ES 2038724T3
- Authority
- ES
- Spain
- Prior art keywords
- radiosensitizers
- preparing
- procedure
- tumor cells
- derivatives useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000004959 2-nitroimidazoles Chemical class 0.000 title 1
- 206010021143 Hypoxia Diseases 0.000 title 1
- 230000001146 hypoxic effect Effects 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
- YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 abstract 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/080,280 US4797397A (en) | 1987-07-31 | 1987-07-31 | 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2038724T3 true ES2038724T3 (es) | 1993-08-01 |
Family
ID=22156378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198888112377T Expired - Lifetime ES2038724T3 (es) | 1987-07-31 | 1988-07-29 | Procedimiento para preparar derivados de 2-nitroimidazol utiles como radiosensibilizadores para celulas tumorales hipoxicas. |
Country Status (7)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8728418D0 (en) * | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| US5036096A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives |
| US5073639A (en) * | 1988-11-25 | 1991-12-17 | Warner-Lambert Company | Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents |
| US5036089A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents |
| US4954515A (en) * | 1988-11-25 | 1990-09-04 | Warner-Lambert Company | Haloalkylaminomethyl-2-nitro-1H-imidazoles |
| GB9113487D0 (en) * | 1991-06-21 | 1991-08-07 | Amersham Int Plc | Agents for hypoxic cells |
| US5432088A (en) * | 1992-03-24 | 1995-07-11 | The Toro Company | Method and apparatus for aerobic composting |
| USD338756S (en) | 1992-03-24 | 1993-08-24 | The Toro Company | Compost bin |
| US6855828B1 (en) | 1992-11-19 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
| EP0669913B1 (en) * | 1992-11-19 | 2003-03-05 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
| US6252087B1 (en) | 1992-11-19 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Nitroaromatic compounds for the detection of hypoxia |
| US5674693A (en) * | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
| US6060604A (en) * | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
| US20050026974A1 (en) * | 1996-02-08 | 2005-02-03 | Trustees Of The University Of Pennsylvania | Detection of hypoxia |
| RU2136628C1 (ru) * | 1997-10-28 | 1999-09-10 | Государственный научный центр Российской Федерации Всероссийский научно-исследовательский институт неорганических материалов им.акад.А.А.Бочвара | СПОСОБ ПОЛУЧЕНИЯ ПОРОШКОВ СВЕРХПРОВОДЯЩЕЙ КЕРАМИКИ Bi - Pb - Sr - Ca - Cu - O |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| US20040191843A1 (en) * | 2003-02-03 | 2004-09-30 | Palo Alto Institute Of Molecular Medicine | Cell-killing molecules and methods of use thereof |
| US20040202694A1 (en) * | 2003-04-11 | 2004-10-14 | Vascular Control Systems, Inc. | Embolic occlusion of uterine arteries |
| EP1838305A1 (en) | 2005-01-21 | 2007-10-03 | Richard H. Matthews | Radiosensitizer formulations comprising nitrohistidine derivatives |
| US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
| US9056136B2 (en) * | 2006-10-06 | 2015-06-16 | Natural Pharmacia International, Inc. | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia |
| US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
| WO2008090732A1 (ja) | 2007-01-26 | 2008-07-31 | Pola Pharma Inc. | 医薬組成物 |
| CN102933258A (zh) * | 2010-03-01 | 2013-02-13 | 因特奥普医药公司 | 与含氧量低的细胞敏化剂联用的放疗 |
| US9084806B2 (en) * | 2012-11-12 | 2015-07-21 | Research & Business Foundation Sungkyunkwan University | Hypoxia-responsive nanoparticle for therapy and imaging of hypoxia-involving diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE45511B1 (en) * | 1976-09-01 | 1982-09-08 | Ciba Geigy Ag | New derivatives of perhydro-aza-heterocycles and processesfor the production thereof |
| IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
| US4282232A (en) * | 1979-04-26 | 1981-08-04 | Research Corporation | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof |
| EP0095906B1 (en) * | 1982-05-27 | 1986-10-22 | National Research Development Corporation | Improvements relating to compounds useful in radiotherapy or chemotherapy |
-
1987
- 1987-07-31 US US07/080,280 patent/US4797397A/en not_active Expired - Fee Related
-
1988
- 1988-07-29 JP JP63188587A patent/JPS6463576A/ja active Pending
- 1988-07-29 AT AT88112377T patent/ATE71094T1/de not_active IP Right Cessation
- 1988-07-29 EP EP88112377A patent/EP0302416B1/en not_active Expired - Lifetime
- 1988-07-29 ES ES198888112377T patent/ES2038724T3/es not_active Expired - Lifetime
- 1988-07-29 DE DE8888112377T patent/DE3867368D1/de not_active Expired - Fee Related
-
1992
- 1992-01-03 GR GR910402052T patent/GR3003503T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3003503T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-03-16 |
| EP0302416B1 (en) | 1992-01-02 |
| US4797397A (en) | 1989-01-10 |
| ATE71094T1 (de) | 1992-01-15 |
| JPS6463576A (en) | 1989-03-09 |
| DE3867368D1 (de) | 1992-02-13 |
| EP0302416A1 (en) | 1989-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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