ES2037723T3 - Amidinacion selectiva de diaminas. - Google Patents

Amidinacion selectiva de diaminas.

Info

Publication number
ES2037723T3
ES2037723T3 ES198787307957T ES87307957T ES2037723T3 ES 2037723 T3 ES2037723 T3 ES 2037723T3 ES 198787307957 T ES198787307957 T ES 198787307957T ES 87307957 T ES87307957 T ES 87307957T ES 2037723 T3 ES2037723 T3 ES 2037723T3
Authority
ES
Spain
Prior art keywords
amidination
diamine
selective
omega
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787307957T
Other languages
English (en)
Inventor
Humberto B. Arzeno
David J. Morgans Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2037723T3 publication Critical patent/ES2037723T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Abstract

PUEDE PREPARARSE UN OMEGA-GUANIDINO-ALFA-AMINOACIDO (O SUS DERIVADOS FUNCIONALES) O UN COMPUESTO QUE LO CONTENGA POR REACCION DEL GRUPO OMEGA UNIDO A UN ALFA, OMEGA-DIAMINOACIDO ( O SUS DERIVADOS FUNCIONALES) O UN COMPUESTO QUE LO CONTENGA CON UN ACIDO FORMAMIDIN-SULFONICO.
ES198787307957T 1986-09-10 1987-09-09 Amidinacion selectiva de diaminas. Expired - Lifetime ES2037723T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90582786A 1986-09-10 1986-09-10

Publications (1)

Publication Number Publication Date
ES2037723T3 true ES2037723T3 (es) 1993-07-01

Family

ID=25421547

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787307957T Expired - Lifetime ES2037723T3 (es) 1986-09-10 1987-09-09 Amidinacion selectiva de diaminas.

Country Status (8)

Country Link
EP (1) EP0260118B1 (es)
JP (1) JP2579323B2 (es)
KR (1) KR960004900B1 (es)
AT (1) ATE70048T1 (es)
DE (1) DE3774975D1 (es)
ES (1) ES2037723T3 (es)
GR (1) GR3003279T3 (es)
HU (1) HU203221B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5627282A (en) * 1996-01-03 1997-05-06 Yukong Limited Process for the preparation of optically pure 1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid and its derivatives
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
AU770459B2 (en) 1998-06-03 2004-02-19 Gpi Nil Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
AU5606400A (en) 1999-07-09 2001-01-30 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
WO2018160178A1 (en) 2017-03-01 2018-09-07 Rgenix, Inc. Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587258A (en) * 1977-06-17 1981-04-01 Gea As Production of substituted guanidines
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4477429A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α -alkyl derivatives of arginine
JPS6061557A (ja) * 1983-09-14 1985-04-09 Nitto Boseki Co Ltd アルギニル−ｐ−ニトロアニリド化合物の製造方法
CN86101850A (zh) * 1985-03-22 1987-02-04 森得克斯(美国)有限公司 N，n′-二烷基胍基二肽的制造方法与用途

Also Published As

Publication number Publication date
EP0260118B1 (en) 1991-12-04
HUT44470A (en) 1988-03-28
EP0260118A1 (en) 1988-03-16
KR880003974A (ko) 1988-06-01
JP2579323B2 (ja) 1997-02-05
ATE70048T1 (de) 1991-12-15
HU203221B (en) 1991-06-28
GR3003279T3 (en) 1993-02-17
KR960004900B1 (ko) 1996-04-17
DE3774975D1 (de) 1992-01-16
JPS6388166A (ja) 1988-04-19

Similar Documents

Publication Publication Date Title
ES2037723T3 (es) Amidinacion selectiva de diaminas.
DE3689672D1 (de) Nylon-Zusammensetzung, modifiziert durch Kautschuk.
TR24372A (tr) Org.peroksi asit agartma oen-maddelerine dayanan aktivatoer bilesimleri
FI864943A0 (fi) Abonnentenhet foer ett traodloest, digitaliskt telefonsystem.
DE69324552D1 (de) N'-substituierte-N,N'Diacylhydrazin-Insektizide
FI872362A (fi) Aongtryck-kokkittel, med taetning foer foersaekring mot tryckets saenkning i kittelns insida.
DE3763424D1 (de) Fluessiges stabiles diperoxysaeure-bleichmittel.
DE3852402D1 (de) Galliumnitridartige Halbleiterverbindung und daraus bestehende lichtemittierende Vorrichtung sowie Verfahren zu deren Herstellung.
DE3787657D1 (de) Aminosäure-Derivate.
DE3683435D1 (de) Stabilisierte wasserhaltige wasserstoffperoxydloesung.
TR23890A (tr) Saf asit borik üretimine mahsus usul.
PL151373B2 (es)
FI864863A0 (fi) Foerfarande foer lastning av styckegods pao lastpallar i ett lastutrymme, saerskilt ett fartygs lastrum.
NO873628L (no) 2,3-dihydro-1h-fenalen-2-amino-forbindelser som antipsykotiske legemidler.
DE3767597D1 (de) Uhr, deren gehaeuse mit einer zusaetzlichen vorrichtung ausgeruestet ist.
FI865279A0 (fi) Profilbelagd foensterkonstruktion, i synnerhet foer bandfoenster.
ATE76868T1 (de) Verfahren zur herstellung von 1,2-disulfonverbindungen.
ATE58735T1 (de) 5-chloro-s-triazolo(4,3-a>pyridin-7-carbonsaeure .
NO873331D0 (no) L-aminodicarboxylsyreestere som er anvendelige som soetningsmidler.
SE8704332L (sv) Drivhus for kultivering
IT209652Z2 (it) Movimento centrale perfezionato per biciclette.
ATE101598T1 (de) Carbonsaeure-derivate.
IT209453Z2 (it) Perno - movimento cavo, particolarmente per cicli.
ATE70265T1 (de) 2-aza-4-(alkoxycarbonyl)spiro-(4,5>decan-3-on.
FI900430A0 (fi) Exotermisk kemisk reaktionsprocess.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 260118

Country of ref document: ES