ES2036479B1 - PROCEDURE FOR PREPARING 1 - (- 2 - ((5-DIMETILAMINOMETIL-2-FURIL) -METILTIO) -AMINO-1-METHYLAMINE-2-NITROETHYLENE. - Google Patents

PROCEDURE FOR PREPARING 1 - (- 2 - ((5-DIMETILAMINOMETIL-2-FURIL) -METILTIO) -AMINO-1-METHYLAMINE-2-NITROETHYLENE.

Info

Publication number
ES2036479B1
ES2036479B1 ES9102480A ES9102480A ES2036479B1 ES 2036479 B1 ES2036479 B1 ES 2036479B1 ES 9102480 A ES9102480 A ES 9102480A ES 9102480 A ES9102480 A ES 9102480A ES 2036479 B1 ES2036479 B1 ES 2036479B1
Authority
ES
Spain
Prior art keywords
methylamine
procedure
metiltio
dimetilaminometil
furil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9102480A
Other languages
Spanish (es)
Other versions
ES2036479A1 (en
Inventor
Andor Jeszenszki
Bela Losonczi
Maria Czeh
Laszlo Godo
Bela Stefko
Tamas Benczik
Maria Perger
Laszlo Hermann
Gabor Havasi
Peter Kalvin
Laszlo Stefan
Tibor Balogh
Endre Kasztreiner
Nandor Makk
Lajos Toldy
Eszter Diesler
Arpad Lazar
Peter Matyus
Emilia Uskert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt, Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Nyrt
Publication of ES2036479A1 publication Critical patent/ES2036479A1/en
Application granted granted Critical
Publication of ES2036479B1 publication Critical patent/ES2036479B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/36—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 1-[2-[(5-DIMETILAMINOMETIL-2-FURIL)-METILTIO]-ETIL]-AMINO-1-METILAMINO-2-NITROTILENO FORMULA (NOMBRTE GENERICO: RANITIDINA), QUE COMPRENDE HACER REACCIONAR EL DERIVADO DE DICETENIMINA DE LA FORMULA (II) FORMULA CON METILAMINA. LA VENTAJA MAS IMPORTANTE DE LA INVENCION CONSISTE EN QUE SE PUEDE PREPARAR RANITIDINA CON UN RENDIMIENTO DE MAS DEL 90% MEDIANTE UN PROCEDIMIENTO SENCILLO.PROCEDURE FOR PREPARING 1- [2 - [(5-DIMETILAMINOMETIL-2-FURIL) -METILTIO] -ETIL] -AMINO-1-METHYLAMINE-2-NITROTILENO FORMULA (GENERIC NAME: RANITIDINA), WHICH INCLUDES TO REACT THE DERIVATIVES OF THE FORMULA (II) FORMULA WITH METHYLAMINE. THE MOST IMPORTANT ADVANTAGE OF THE INVENTION IS THAT RANITIDINE CAN BE PREPARED WITH A YIELD OF MORE THAN 90% THROUGH A SIMPLE PROCEDURE.

ES9102480A 1990-11-09 1991-11-08 PROCEDURE FOR PREPARING 1 - (- 2 - ((5-DIMETILAMINOMETIL-2-FURIL) -METILTIO) -AMINO-1-METHYLAMINE-2-NITROETHYLENE. Expired - Lifetime ES2036479B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU907074A HU207308B (en) 1990-11-09 1990-11-09 Process for producing 1- /2-/5-/dimethyl-amino-methyl/-2-/furyl-methyl-thio/-ethyl//- -amino-1-/methyl-amino-2-nitro-ethylene

Publications (2)

Publication Number Publication Date
ES2036479A1 ES2036479A1 (en) 1993-05-16
ES2036479B1 true ES2036479B1 (en) 1993-12-16

Family

ID=10972142

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102480A Expired - Lifetime ES2036479B1 (en) 1990-11-09 1991-11-08 PROCEDURE FOR PREPARING 1 - (- 2 - ((5-DIMETILAMINOMETIL-2-FURIL) -METILTIO) -AMINO-1-METHYLAMINE-2-NITROETHYLENE.

Country Status (16)

Country Link
KR (1) KR920009813A (en)
CN (1) CN1061968A (en)
AR (1) AR248017A1 (en)
AT (1) AT400146B (en)
CA (1) CA2055189A1 (en)
CZ (1) CZ280197B6 (en)
DK (1) DK184291A (en)
ES (1) ES2036479B1 (en)
FI (1) FI915265A (en)
GR (1) GR1002225B (en)
HU (1) HU207308B (en)
NO (1) NO179208C (en)
PL (1) PL166616B1 (en)
PT (1) PT99470A (en)
RU (1) RU2032681C1 (en)
YU (1) YU177391A (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2115111B (en) * 1982-01-25 1987-01-14 Ava Int Corp Fail safe gate valves and actuators therefor
ES543966A0 (en) * 1982-11-22 1986-03-01 Medichem Sa PROCEDURE FOR THE PREPARATION OF N- (2 - ((((5- (DIMETILA-MINO) -METIL-2-FURANIL) METHYL) THIO) ETIL) -N'-METHYL-2-NITRO-1,1- ETENDIAMINE
YU42819B (en) * 1982-11-22 1988-12-31 Lek Tovarna Farmacevtskih Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
HU196979B (en) * 1985-01-11 1989-02-28 Gyogyszerkutato Intezet Process for producing basic thioether and salt
ES8603706A1 (en) * 1985-06-12 1986-01-16 Medichem Sa Nitro:ethylidene di:amine deriv.

Also Published As

Publication number Publication date
CN1061968A (en) 1992-06-17
NO914376D0 (en) 1991-11-08
HU207308B (en) 1993-03-29
DK184291D0 (en) 1991-11-08
PL166616B1 (en) 1995-06-30
DK184291A (en) 1992-05-10
CS340391A3 (en) 1992-05-13
CA2055189A1 (en) 1992-05-10
ES2036479A1 (en) 1993-05-16
FI915265A0 (en) 1991-11-08
ATA220391A (en) 1995-02-15
NO914376L (en) 1992-05-11
HU907074D0 (en) 1991-05-28
GR1002225B (en) 1996-04-18
AR248017A1 (en) 1995-05-31
PL292327A1 (en) 1992-07-13
AT400146B (en) 1995-10-25
PT99470A (en) 1992-10-30
CZ280197B6 (en) 1995-11-15
CA2055189C (en) 1992-05-10
KR920009813A (en) 1992-06-25
YU177391A (en) 1994-01-20
GR910100451A (en) 1992-10-08
FI915265A (en) 1992-05-10
RU2032681C1 (en) 1995-04-10
NO179208C (en) 1996-08-28
HUT59916A (en) 1992-07-28
NO179208B (en) 1996-05-20

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