ES2021940A6 - Procedimiento para la preparacion de nuevos derivados de pirimidina con actividad serotoninergica. - Google Patents

Procedimiento para la preparacion de nuevos derivados de pirimidina con actividad serotoninergica.

Info

Publication number
ES2021940A6
ES2021940A6 ES9000368A ES9000368A ES2021940A6 ES 2021940 A6 ES2021940 A6 ES 2021940A6 ES 9000368 A ES9000368 A ES 9000368A ES 9000368 A ES9000368 A ES 9000368A ES 2021940 A6 ES2021940 A6 ES 2021940A6
Authority
ES
Spain
Prior art keywords
alpha
serotoninergical
piperazinyl
heteroaryl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9000368A
Other languages
English (en)
Inventor
Pinol Augusto Colombo
Constansa Jordi Frigola
Corominas Juan Pares
Vidal Ramon Merce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2021940A6 publication Critical patent/ES2021940A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PIRIMIDINA CON ACTIVIDAD SEROTONINERGICA, QUE RESPONDEN A LA FORMULA GENERAL (I), EN EL QUE SE HACE REACCIONAR UN COMPUESTO DE LA FORMULA GENERAL (II): CON UN COMPUESTO DE FORMULA GENERAL (III) EFECTUANDOSE LA REACCION EN EL SENO DE UN SOLVENTE ADECUADO, TAL COMO UN HIDROCARBURO, UN SOLVENTE HALOGENADO, UN ETER O UN SOLVENTE APROTICO Y EN PRESENCIA DE UNA BASE TAL COMO LOS HIDROXIDOS, CARBONATOS O BICARBONATOS DE METALES ALCALINOS Y DE UN CATALIZADOR DE TRANSFERENCIA DE FASE, ESTANDO LA TEMPERATURA COMPRENDIDA ENTRE LA TEMPERATURA AMBIENTE Y LA DE REFLUJO DEL SOLVENTE Y ESTANDO EL TIEMPO DE REACCION COMPRENDIDO ENTRE 1 Y 24 HORAS; EL SIGNIFICADO DE LOS SUSTITUYENTES DE LAS ANTESRIORES FORMULAS Y OTRAS VARIANTES DEL PROCEDIMIENTO SE INDICAN EN LA DESCRIPCION. LOS COMPUESTOS OBTENIDOS SON UTILIZABLES COMO INTERMEDIOS Y PARA LA PREPARACION DE MEDICAMENTOS ANSIOLITICOS O TRANQUILIZANTES.
ES9000368A 1989-02-09 1990-02-08 Procedimiento para la preparacion de nuevos derivados de pirimidina con actividad serotoninergica. Expired - Lifetime ES2021940A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8901699A FR2642758B1 (fr) 1989-02-09 1989-02-09 Derives de pyrimidine,2-(4-((alpha)-heteroaryl-(alpha) aryl-((alpha)-alkyl)-methoxy)-butyl)-1-piperazinyl), avec activite serotoninergique

Publications (1)

Publication Number Publication Date
ES2021940A6 true ES2021940A6 (es) 1991-11-16

Family

ID=9378641

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000368A Expired - Lifetime ES2021940A6 (es) 1989-02-09 1990-02-08 Procedimiento para la preparacion de nuevos derivados de pirimidina con actividad serotoninergica.

Country Status (5)

Country Link
EP (1) EP0382636B1 (es)
AT (1) ATE92058T1 (es)
DE (1) DE69002340T2 (es)
ES (1) ES2021940A6 (es)
FR (1) FR2642758B1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5656762A (en) * 1990-12-28 1997-08-12 Neurogen Corporation 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands

Also Published As

Publication number Publication date
EP0382636A1 (fr) 1990-08-16
FR2642758B1 (fr) 1991-05-17
DE69002340T2 (de) 1993-12-02
FR2642758A1 (fr) 1990-08-10
ATE92058T1 (de) 1993-08-15
DE69002340D1 (de) 1993-09-02
EP0382636B1 (fr) 1993-07-28

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