ES2014187A6 - Process for the preparation of laevo-and dextro-dropropizine - Google Patents

Process for the preparation of laevo-and dextro-dropropizine

Info

Publication number
ES2014187A6
ES2014187A6 ES8902707A ES8902707A ES2014187A6 ES 2014187 A6 ES2014187 A6 ES 2014187A6 ES 8902707 A ES8902707 A ES 8902707A ES 8902707 A ES8902707 A ES 8902707A ES 2014187 A6 ES2014187 A6 ES 2014187A6
Authority
ES
Spain
Prior art keywords
dropropizine
laevo
dextro
preparation
glycidol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8902707A
Other languages
Spanish (es)
Inventor
Carlo Polacci
Massimiliano Lussana
Alberto Gallazzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bidachem SpA
Original Assignee
Bidachem SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bidachem SpA filed Critical Bidachem SpA
Publication of ES2014187A6 publication Critical patent/ES2014187A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The preparation of laevo-dropropizine and dextro-dropropizine is carried out by selectively reacting 1-phenylpiperazine with (R)-glycidol and (S)-glycidol, respectively. Application to the simple and selective preparation of laevo-dropropizine and dextro-dropropizine with good yields.
ES8902707A 1988-08-01 1989-07-31 Process for the preparation of laevo-and dextro-dropropizine Expired - Lifetime ES2014187A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821611A IT1226570B (en) 1988-08-01 1988-08-01 LEVO- AND RIGHT-DROPROPIZINE PREPARATION PROCEDURE

Publications (1)

Publication Number Publication Date
ES2014187A6 true ES2014187A6 (en) 1990-06-16

Family

ID=11184306

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8902707A Expired - Lifetime ES2014187A6 (en) 1988-08-01 1989-07-31 Process for the preparation of laevo-and dextro-dropropizine

Country Status (5)

Country Link
ES (1) ES2014187A6 (en)
FR (1) FR2634765B1 (en)
IT (1) IT1226570B (en)
LU (1) LU87538A1 (en)
NL (1) NL8901701A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231158B (en) * 1989-07-20 1991-11-19 Dompe Farmaceutici Spa PROCEDURE FOR THE OPTICAL RESOLUTION OF DRUG.
IT1254452B (en) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-OXIDES AND N, N'-DIOXIDES OF 3- (PIPERAZIN-1-IL) -PROPAN-1,2-DIOLS
IT1254993B (en) * 1992-06-24 1995-10-11 PROCEDURE FOR THE PREPARATION OF THE ENANTIOMERS OF DROPROPIZINE
IT1318650B1 (en) * 2000-07-28 2003-08-27 Dompe Spa 1,3-DIOSSOLANS WITH ANTI-TOXIC ACTIVITY.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB938646A (en) * 1961-03-16 1963-10-02 Henri Morren New piperazine derivatives
IT1203721B (en) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa OPTICALLY ACTIVE COMPOUNDS WITH ANTITOSSE AND CENTRAL SEDATIVE ACTIVITIES, PROCEDURE FOR PREPARATION AND COMPOSITIONS CONTAINING THEM
NL8801622A (en) * 1988-06-25 1990-01-16 Stamicarbon PREPARATION OF ENANTIOMERS OF DROPROPIZINE.

Also Published As

Publication number Publication date
FR2634765B1 (en) 1994-05-27
IT1226570B (en) 1991-01-24
NL8901701A (en) 1990-03-01
LU87538A1 (en) 1991-02-18
IT8821611A0 (en) 1988-08-01
FR2634765A1 (en) 1990-02-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100315