ES2011986A6 - Procedimiento para preparar derivados de ergolina. - Google Patents

Procedimiento para preparar derivados de ergolina.

Info

Publication number
ES2011986A6
ES2011986A6 ES8900243A ES8900243A ES2011986A6 ES 2011986 A6 ES2011986 A6 ES 2011986A6 ES 8900243 A ES8900243 A ES 8900243A ES 8900243 A ES8900243 A ES 8900243A ES 2011986 A6 ES2011986 A6 ES 2011986A6
Authority
ES
Spain
Prior art keywords
ergoline derivatives
compounds
ergoline
derivatives
alkey
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8900243A
Other languages
English (en)
Inventor
Roland Achini
Rene Amstutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2011986A6 publication Critical patent/ES2011986A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ERGOLINA DE FORMULA (I) EN DONDE R1 ES HIDROGENO O ALQUILO (C1-4) Y R2 ES FURANILO, FENILO O UN GRUPO FENILO MONO- O DISUSTITUIDO POR FLUOR, CLORO, BROMO, ALQUILO (C1-4), TRIFLUOROMETILO O ALCOXI(C1-4). COMPRENDE OXIDAR LA CORRESPONDIENTE 2,3-DIHIDRO-ERGOLINA DE FORMULA (II) Y RECUPERAR EL COMPUESTO RESULTANTE EN FORMA DE BASE LIBRE O EN LA FORMA DE SAL DE ADICION DE ACIDO. LOS COMPUESTOS DE FORMULA (I) EXHIBEN ACTIVIDAD FARMACOLOGICA Y PUEDEN SER USADOS COMO FARMACOS.
ES8900243A 1988-01-26 1989-01-25 Procedimiento para preparar derivados de ergolina. Expired - Lifetime ES2011986A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3802178 1988-01-26

Publications (1)

Publication Number Publication Date
ES2011986A6 true ES2011986A6 (es) 1990-02-16

Family

ID=6345984

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900243A Expired - Lifetime ES2011986A6 (es) 1988-01-26 1989-01-25 Procedimiento para preparar derivados de ergolina.

Country Status (17)

Country Link
JP (1) JPH01224374A (es)
KR (1) KR890011882A (es)
AU (1) AU2872489A (es)
DK (1) DK32389A (es)
ES (1) ES2011986A6 (es)
FI (1) FI890337A (es)
FR (1) FR2626177B1 (es)
GB (1) GB2214183A (es)
GR (1) GR890100048A (es)
HU (1) HUT51275A (es)
IL (1) IL89063A0 (es)
IT (1) IT1229537B (es)
LU (1) LU87439A1 (es)
NL (1) NL8900185A (es)
PT (1) PT89518B (es)
SE (1) SE8900256L (es)
ZA (1) ZA89640B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
IL105168A0 (en) * 1992-04-03 1993-07-08 Lilly Co Eli Heteroannulation process

Also Published As

Publication number Publication date
GB8901440D0 (en) 1989-03-15
DK32389A (da) 1989-07-27
PT89518B (pt) 1994-02-28
GR890100048A (el) 1994-03-31
IL89063A0 (en) 1989-08-15
PT89518A (pt) 1989-10-04
GB2214183A (en) 1989-08-31
IT1229537B (it) 1991-09-04
SE8900256L (sv) 1989-07-27
SE8900256D0 (sv) 1989-01-25
KR890011882A (ko) 1989-08-23
FR2626177B1 (fr) 1992-07-31
JPH01224374A (ja) 1989-09-07
ZA89640B (en) 1990-09-26
AU2872489A (en) 1989-07-27
LU87439A1 (fr) 1989-08-30
FI890337A0 (fi) 1989-01-24
FI890337A (fi) 1989-07-27
HUT51275A (en) 1990-04-28
IT8947562A0 (it) 1989-01-24
NL8900185A (nl) 1989-08-16
FR2626177A1 (fr) 1989-07-28
DK32389D0 (da) 1989-01-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991102