ES2006390A6 - Procedimiento de preparacion de nuevos derivados de morfolina. - Google Patents

Procedimiento de preparacion de nuevos derivados de morfolina.

Info

Publication number
ES2006390A6
ES2006390A6 ES8800903A ES8800903A ES2006390A6 ES 2006390 A6 ES2006390 A6 ES 2006390A6 ES 8800903 A ES8800903 A ES 8800903A ES 8800903 A ES8800903 A ES 8800903A ES 2006390 A6 ES2006390 A6 ES 2006390A6
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
morpholine derivatives
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800903A
Other languages
English (en)
Inventor
Gilbert Regnier
Claude Guillonneau
Jean Lepagnol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES2006390A6 publication Critical patent/ES2006390A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Earth Drilling (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Control For Baths (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LOS NUEVOS DERIVADOS UTILIZABLES COMO MEDICAMENTOS RESPONDEN A LA FORMULA (I), EN LA QUE R1 ES HIDROGENO, ALQUILO (C1-6) EN CADENA LINEAL O RAMIFICADA QUE COMPRENDE EVENTUALMENTE UN DOBLE ENLACE, ARALQUILO EVENTUALMENTE SUSTITUIDO, CICLOALQUILO (C5-C6) O ACILO (C2-C3); Y R2 ES HIDROGENO, ALQUILO (C1-C6) EN CADENA LINEAL O RAMIFICADA QUE COMPRENDE EVENTUALMENTE UN DOBLE ENLACE, ARALQUILO EVENTUALMENTE SUSTITUIDO O ACILO (C2-C3); SUS ENANTIOMEROS Y SUS SALES FISIOLOGICAMENTE TOLERABLES, SE PREPARAN A PARTIR DE MORFOLINA SUSTITUIDA DE FORMULA (II) EN LA QUE R1 ES LO QUE ANTERIORMENTE SE DEFINE Y X ES HALOGENO O TOSILOXILO, Y DE UNA HIDROXIQUINOLEINA DE FORMULA (III).LOS PRODUCTOS DE LA INVENCION PUEDEN UTILIZARSE EN TERAPEUTICA ESPECIALMENTE EN EL TRATAMIENTO DE SINDROMES ISQUEMICOS Y DEL ENVEJECIMIENTO CEREBRAL.
ES8800903A 1987-03-24 1988-03-24 Procedimiento de preparacion de nuevos derivados de morfolina. Expired ES2006390A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8704047A FR2612926B1 (fr) 1987-03-24 1987-03-24 Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2006390A6 true ES2006390A6 (es) 1989-04-16

Family

ID=9349348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800903A Expired ES2006390A6 (es) 1987-03-24 1988-03-24 Procedimiento de preparacion de nuevos derivados de morfolina.

Country Status (17)

Country Link
US (1) US4782054A (es)
EP (1) EP0286495B1 (es)
JP (1) JPH0657709B2 (es)
AT (1) ATE89281T1 (es)
AU (1) AU600209B2 (es)
CA (1) CA1313870C (es)
DE (1) DE3880874T2 (es)
DK (1) DK171580B1 (es)
ES (1) ES2006390A6 (es)
FR (1) FR2612926B1 (es)
GR (1) GR1000241B (es)
HK (1) HK57297A (es)
IE (1) IE61882B1 (es)
NZ (1) NZ223984A (es)
OA (1) OA08822A (es)
PT (1) PT87061B (es)
ZA (1) ZA882107B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2653999A1 (fr) * 1989-11-06 1991-05-10 Adir Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds
KR100943555B1 (ko) * 2004-04-30 2010-02-22 워너-램버트 캄파니 엘엘씨 중추신경계 장애를 치료하기 위한 치환된 모르폴린 화합물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138405A (en) * 1966-12-28 1969-01-01 Ici Ltd Morpholine derivatives
BE758766A (fr) * 1969-11-17 1971-05-10 Ici Ltd Nouveaux derives de la morpholine et de la

Also Published As

Publication number Publication date
ATE89281T1 (de) 1993-05-15
PT87061B (pt) 1992-07-31
GR1000241B (el) 1992-05-12
DK171580B1 (da) 1997-02-03
GR880100179A (en) 1989-01-31
OA08822A (fr) 1989-03-31
IE61882B1 (en) 1994-11-30
DK150088D0 (da) 1988-03-18
NZ223984A (en) 1990-05-28
AU1352088A (en) 1988-09-22
EP0286495A1 (fr) 1988-10-12
HK57297A (en) 1997-05-09
DE3880874T2 (de) 1993-12-23
PT87061A (pt) 1988-04-01
ZA882107B (en) 1989-06-28
FR2612926B1 (fr) 1989-06-09
IE880851L (en) 1988-09-24
JPS63255279A (ja) 1988-10-21
US4782054A (en) 1988-11-01
EP0286495B1 (fr) 1993-05-12
AU600209B2 (en) 1990-08-02
CA1313870C (fr) 1993-02-23
DK150088A (da) 1988-09-25
FR2612926A1 (fr) 1988-09-30
DE3880874D1 (de) 1993-06-17
JPH0657709B2 (ja) 1994-08-03

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