ES2004919A6 - N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn. - Google Patents

N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.

Info

Publication number
ES2004919A6
ES2004919A6 ES8700966A ES8700966A ES2004919A6 ES 2004919 A6 ES2004919 A6 ES 2004919A6 ES 8700966 A ES8700966 A ES 8700966A ES 8700966 A ES8700966 A ES 8700966A ES 2004919 A6 ES2004919 A6 ES 2004919A6
Authority
ES
Spain
Prior art keywords
guanidino
propionamidine
sulphamoyl
prepn
methylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8700966A
Other languages
Spanish (es)
Inventor
Fulvio Benigni
Bruno Sala
Enrico Vigano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industriale Chimica SRL
Original Assignee
Industriale Chimica SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industriale Chimica SRL filed Critical Industriale Chimica SRL
Publication of ES2004919A6 publication Critical patent/ES2004919A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

N-Sulphamoyl 3-((2-guanidino thiazol-4-yl)methylthio) propionamidine of formula (I) is made by (a) reacting the sulphamate ester (IV) of o-diphenol with methyl 3-((2-guanidino thiazol-4-yl)methylthio propionimidate (II) to give N-(2-hydroxyphenoxy sulphonyl) 3-(2-guanidino thiazol-4-yl) methyl thio) propionamidine (V); and (b) reacting this with ammonia to give (I), which is an anti-ulcer agent.
ES8700966A 1986-11-14 1987-04-03 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn. Expired ES2004919A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22336/86A IT1198092B (en) 1986-11-14 1986-11-14 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.

Publications (1)

Publication Number Publication Date
ES2004919A6 true ES2004919A6 (en) 1989-02-16

Family

ID=11194854

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8700966A Expired ES2004919A6 (en) 1986-11-14 1987-04-03 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.

Country Status (3)

Country Link
KR (1) KR880006216A (en)
ES (1) ES2004919A6 (en)
IT (1) IT1198092B (en)

Also Published As

Publication number Publication date
IT8622336A1 (en) 1988-05-14
IT1198092B (en) 1988-12-21
KR880006216A (en) 1988-07-22
IT8622336A0 (en) 1986-11-14

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