IT1198092B - N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn. - Google Patents

N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.

Info

Publication number
IT1198092B
IT1198092B IT22336/86A IT2233686A IT1198092B IT 1198092 B IT1198092 B IT 1198092B IT 22336/86 A IT22336/86 A IT 22336/86A IT 2233686 A IT2233686 A IT 2233686A IT 1198092 B IT1198092 B IT 1198092B
Authority
IT
Italy
Prior art keywords
guanidino
propionamidine
sulphamoyl
prepn
methylthio
Prior art date
Application number
IT22336/86A
Other languages
Italian (it)
Other versions
IT8622336A1 (en
IT8622336A0 (en
Inventor
Fulvio Benigni
Bruno Sala
Enrico Vigano'
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Priority to IT22336/86A priority Critical patent/IT1198092B/en
Publication of IT8622336A0 publication Critical patent/IT8622336A0/en
Priority to ES8700966A priority patent/ES2004919A6/en
Priority to KR1019870008137A priority patent/KR880006216A/en
Publication of IT8622336A1 publication Critical patent/IT8622336A1/en
Application granted granted Critical
Publication of IT1198092B publication Critical patent/IT1198092B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

N-Sulphamoyl 3-((2-guanidino thiazol-4-yl)methylthio) propionamidine of formula (I) is made by (a) reacting the sulphamate ester (IV) of o-diphenol with methyl 3-((2-guanidino thiazol-4-yl)methylthio propionimidate (II) to give N-(2-hydroxyphenoxy sulphonyl) 3-(2-guanidino thiazol-4-yl) methyl thio) propionamidine (V); and (b) reacting this with ammonia to give (I), which is an anti-ulcer agent.
IT22336/86A 1986-11-14 1986-11-14 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn. IT1198092B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT22336/86A IT1198092B (en) 1986-11-14 1986-11-14 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.
ES8700966A ES2004919A6 (en) 1986-11-14 1987-04-03 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.
KR1019870008137A KR880006216A (en) 1986-11-14 1987-07-25 Method for preparing N-sulfamoylamidine and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22336/86A IT1198092B (en) 1986-11-14 1986-11-14 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.

Publications (3)

Publication Number Publication Date
IT8622336A0 IT8622336A0 (en) 1986-11-14
IT8622336A1 IT8622336A1 (en) 1988-05-14
IT1198092B true IT1198092B (en) 1988-12-21

Family

ID=11194854

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22336/86A IT1198092B (en) 1986-11-14 1986-11-14 N-sulphamoyl guanidino-thiazolyl methylthio propionamidine prepn.

Country Status (3)

Country Link
KR (1) KR880006216A (en)
ES (1) ES2004919A6 (en)
IT (1) IT1198092B (en)

Also Published As

Publication number Publication date
IT8622336A1 (en) 1988-05-14
ES2004919A6 (en) 1989-02-16
KR880006216A (en) 1988-07-22
IT8622336A0 (en) 1986-11-14

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Effective date: 19931129