ES2004333A4 - Proceso para preparar (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis (2,6-piperazinadiona). - Google Patents

Proceso para preparar (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis (2,6-piperazinadiona).

Info

Publication number
ES2004333A4
ES2004333A4 ES88870051T ES88870051T ES2004333A4 ES 2004333 A4 ES2004333 A4 ES 2004333A4 ES 88870051 T ES88870051 T ES 88870051T ES 88870051 T ES88870051 T ES 88870051T ES 2004333 A4 ES2004333 A4 ES 2004333A4
Authority
ES
Spain
Prior art keywords
bis
methyl
piperazinadiona
ethanodiyl
prepare
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES88870051T
Other languages
English (en)
Inventor
William David Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Erbamont Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erbamont Inc filed Critical Erbamont Inc
Publication of ES2004333A4 publication Critical patent/ES2004333A4/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyurethanes Or Polyureas (AREA)

Abstract

EL COMPUESTO (S)(+)-4,4''-(1-METIL-1,2-ETANODIIL)-BIS (2,6-PIPERAZINADIONA) SE PREPARA TRATANDO PROPILENDIAMINA TETRACETICO TETRAMIDA EN UN DISOLVENTE APROTICO DIPOLAR CON UN DERIVADO DE METAL ALCALINO DE SULFOXIDO DE DIMETILO PARA FORMAR UNA SAL DE METAL DIALCALINO DE (S)(+)-4,4''-(1-METIL -1,2-ETANODIIL)-BIS (2,6-PIPERAZINADIONA); Y NEUTRALIZAR LA SAL DE METAL DIALCALINO.
ES88870051T 1987-03-23 1988-03-22 Proceso para preparar (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis (2,6-piperazinadiona). Pending ES2004333A4 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/029,038 US4764614A (en) 1987-03-23 1987-03-23 Process for preparing (S)(+)-4,4'(methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)

Publications (1)

Publication Number Publication Date
ES2004333A4 true ES2004333A4 (es) 1989-01-01

Family

ID=21846891

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88870051T Pending ES2004333A4 (es) 1987-03-23 1988-03-22 Proceso para preparar (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis (2,6-piperazinadiona).

Country Status (8)

Country Link
US (1) US4764614A (es)
EP (1) EP0284594B1 (es)
JP (1) JPS6463577A (es)
AT (1) ATE84528T1 (es)
AU (1) AU588727B2 (es)
CA (1) CA1304378C (es)
DE (1) DE3877396D1 (es)
ES (1) ES2004333A4 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0674251B2 (ja) * 1986-02-07 1994-09-21 全薬工業株式▲会▼社 ビス−ジオキソピペラジン誘導体
US4963551A (en) * 1987-12-21 1990-10-16 Erbamont Inc. Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and solutions thereof
US5744455A (en) * 1988-01-27 1998-04-28 New York University Reduction of anthracycline-induced cardiotoxicity
US4963679A (en) * 1988-02-17 1990-10-16 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes
GB9122677D0 (en) * 1991-10-25 1991-12-11 Eurocetus Bv Process for preparing(s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
US5760039A (en) * 1991-10-25 1998-06-02 Chiron Corporation Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
US5688797A (en) * 1996-04-26 1997-11-18 Thomas Jefferson University Treatment of acute central nervous system injury with piperazine derivatives
AT504621B1 (de) * 2006-11-24 2014-08-15 Cyathus Exquirere Pharmaforschungsgmbh Neues verfahren zur herstellung von 4,4'-(1-methyl -1,2-ethandiyl)-bis-(2,6-piperazindion)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234935A (en) * 1967-07-03 1971-06-09 Nat Res Dev Piperazine derivatives
US3941790A (en) * 1967-07-03 1976-03-02 National Research Development Corporation Bis diketopiperazines
GB1236947A (en) * 1968-08-15 1971-06-23 Ici Ltd Process for the preparation of piperazine derivatives
US4963679A (en) * 1988-02-17 1990-10-16 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes

Also Published As

Publication number Publication date
AU1338388A (en) 1988-09-22
DE3877396D1 (de) 1993-02-25
AU588727B2 (en) 1989-09-21
US4764614A (en) 1988-08-16
EP0284594A2 (en) 1988-09-28
JPH0541631B2 (es) 1993-06-24
ATE84528T1 (de) 1993-01-15
CA1304378C (en) 1992-06-30
EP0284594B1 (en) 1993-01-13
EP0284594A3 (en) 1989-04-26
JPS6463577A (en) 1989-03-09

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