ATE84528T1 - Verfahren zur herstellung von (s)(+)-4,4'-(1methyl-1,2-ethandiyl)-bis-(2,6-piperazindion). - Google Patents

Verfahren zur herstellung von (s)(+)-4,4'-(1methyl-1,2-ethandiyl)-bis-(2,6-piperazindion).

Info

Publication number
ATE84528T1
ATE84528T1 AT88870051T AT88870051T ATE84528T1 AT E84528 T1 ATE84528 T1 AT E84528T1 AT 88870051 T AT88870051 T AT 88870051T AT 88870051 T AT88870051 T AT 88870051T AT E84528 T1 ATE84528 T1 AT E84528T1
Authority
AT
Austria
Prior art keywords
ethanediyl
bis
piperazindone
1methyl
preparation
Prior art date
Application number
AT88870051T
Other languages
English (en)
Inventor
William David Miller
Original Assignee
Erbamont Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erbamont Inc filed Critical Erbamont Inc
Application granted granted Critical
Publication of ATE84528T1 publication Critical patent/ATE84528T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyurethanes Or Polyureas (AREA)
AT88870051T 1987-03-23 1988-03-22 Verfahren zur herstellung von (s)(+)-4,4'-(1methyl-1,2-ethandiyl)-bis-(2,6-piperazindion). ATE84528T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/029,038 US4764614A (en) 1987-03-23 1987-03-23 Process for preparing (S)(+)-4,4'(methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
EP88870051A EP0284594B1 (de) 1987-03-23 1988-03-22 Verfahren zur Herstellung von (S)(+)-4,4'-(1-Methyl-1,2-ethandiyl)-bis-(2,6-piperazindion)

Publications (1)

Publication Number Publication Date
ATE84528T1 true ATE84528T1 (de) 1993-01-15

Family

ID=21846891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88870051T ATE84528T1 (de) 1987-03-23 1988-03-22 Verfahren zur herstellung von (s)(+)-4,4'-(1methyl-1,2-ethandiyl)-bis-(2,6-piperazindion).

Country Status (8)

Country Link
US (1) US4764614A (de)
EP (1) EP0284594B1 (de)
JP (1) JPS6463577A (de)
AT (1) ATE84528T1 (de)
AU (1) AU588727B2 (de)
CA (1) CA1304378C (de)
DE (1) DE3877396D1 (de)
ES (1) ES2004333A4 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0674251B2 (ja) * 1986-02-07 1994-09-21 全薬工業株式▲会▼社 ビス−ジオキソピペラジン誘導体
US4963551A (en) * 1987-12-21 1990-10-16 Erbamont Inc. Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and solutions thereof
US5744455A (en) * 1988-01-27 1998-04-28 New York University Reduction of anthracycline-induced cardiotoxicity
US4963679A (en) * 1988-02-17 1990-10-16 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes
US5760039A (en) * 1991-10-25 1998-06-02 Chiron Corporation Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
GB9122677D0 (en) * 1991-10-25 1991-12-11 Eurocetus Bv Process for preparing(s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
US5688797A (en) * 1996-04-26 1997-11-18 Thomas Jefferson University Treatment of acute central nervous system injury with piperazine derivatives
AT504621B1 (de) * 2006-11-24 2014-08-15 Cyathus Exquirere Pharmaforschungsgmbh Neues verfahren zur herstellung von 4,4'-(1-methyl -1,2-ethandiyl)-bis-(2,6-piperazindion)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941790A (en) * 1967-07-03 1976-03-02 National Research Development Corporation Bis diketopiperazines
GB1234935A (en) * 1967-07-03 1971-06-09 Nat Res Dev Piperazine derivatives
GB1236947A (en) * 1968-08-15 1971-06-23 Ici Ltd Process for the preparation of piperazine derivatives
US4963679A (en) * 1988-02-17 1990-10-16 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes

Also Published As

Publication number Publication date
AU1338388A (en) 1988-09-22
CA1304378C (en) 1992-06-30
EP0284594B1 (de) 1993-01-13
EP0284594A2 (de) 1988-09-28
US4764614A (en) 1988-08-16
EP0284594A3 (en) 1989-04-26
JPH0541631B2 (de) 1993-06-24
DE3877396D1 (de) 1993-02-25
JPS6463577A (en) 1989-03-09
ES2004333A4 (es) 1989-01-01
AU588727B2 (en) 1989-09-21

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties